Patanol (Olopatadine Hydrochloride) - Summary

PATANOL SUMMARY

PATANOL® (olopatadine hydrochloride ophthalmic solution) 0.1% is a sterile ophthalmic solution containing olopatadine, a relatively selective H₁- receptor antagonist and inhibitor of histamine release from the mast cell for topical administration to the eyes.

PATANOL (olopatadine hydrochloride ophthalmic solution) 0.1% is indicated for the treatment of the signs and symptoms of allergic conjunctivitis.

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NEWS HIGHLIGHTS

Published Studies Related to Patanol (Olopatadine)

Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers. [2012]
Since most first-generation antihistamines have undesirable sedative effects on the central nervous systems (CNS), newer (second-generation) antihistamines have been developed to improve patients' quality of life. However, there are few reports that directly compare the antihistaminic efficacy and impairment of psychomotor functions...

Comprehensive report of olopatadine 0.6% nasal spray as treatment for children with seasonal allergic rhinitis. [2011.05]
Allergic rhinitis (AR) is highly prevalent in children...

Two-week comparison study of olopatadine hydrochloride nasal spray 0.6% versus azelastine hydrochloride nasal spray 0.1% in patients with vasomotor rhinitis. [2011.03]
Olopatadine hydrochloride nasal spray 0.6% (OLO) and azelastine nasal spray 137 micrograms (AZE) are effective in treating allergic rhinitis and AZE is indicated for nonallergic vasomotor rhinitis (VMR). This study evaluates the relative safety and efficacy of OLO and AZE in patients with VMR.

Mometasone furoate nasal spray for moderate-to-severe nasal congestion in subjects with seasonal allergic rhinitis. [2011]
Nasal congestion is a frequent, bothersome symptom of seasonal allergic rhinitis (SAR). Mometasone furoate nasal spray (MFNS) has established efficacy in treating nasal allergy symptoms, but no study has been conducted with the primary purpose of evaluating MFNS for relief of congestion...

Olopatadine hydrochloride in children: efficacy and safety for perennial allergic rhinitis. [2010.07]
OBJECTIVE: The efficacy of antihistamines in perennial allergic rhinitis in children has been evaluated in studies using active comparators, whereas placebo-controlled studies are very few. A randomized, multicenter, double-blind, parallel-group clinical study was carried out to evaluate the dose-response relationship and superiority of olopatadine hydrochloride over placebo in children aged 7 to 16 years with perennial allergic rhinitis... CONCLUSIONS: Olopatadine hydrochloride 5 mg twice daily is an effective and safe treatment for perennial allergic rhinitis in children.

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Clinical Trials Related to Patanol (Olopatadine)

Efficacy and Safety of an Ophthalmic Solution in Patients With Allergic Conjunctivitis [Recruiting]
The purpose of this study is to evaluate an ophthalmic solution for the treatment of ocular itching associated with allergic conjunctivitis using the Conjunctival Allergen Challenge (CAC) model.

Comparing Patient Satisfaction With Pataday or Bepreve [Recruiting]
The purpose of this study is to compare patient satisfaction with Pataday (Olopatadine hydrochloride 0. 2%) one daily (QD) and Bepreve (Bepotastine besilate ophthalmic solution 1. 5%) two times a day (BID).

Clinical Efficacy of PRO-118 Compared With Olopatadine Hydrochloride Ophthalmic Solution in Allergic Conjunctivitis [Not yet recruiting]
The purpose of this study is to evaluate the clinical efficacy of the ophthalmic solution PRO-118 compared with olopatadine hydrochloride ophthalmic solution in allergic conjunctivitis.

Confocal Analysis of Corneal Structures of Symptomatic Allergic Conjunctivitis Patients [Recruiting]

Safety and Pharmacokinetics of Patanase in Pediatric Patients 2 to < 6 Years of Age [Recruiting]
The purpose of the study is to assess the safety of the study drug, Patanase (Olopatadine Hydrochloride Nasal Spray 0. 6%) compared to placebo (inactive substance) in children ages 2 to less than 6 who have a history of nasal allergies, and to assess the pharmcokinetics (study of the action of a drug in the body) in these children

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Reports of Suspected Patanol (Olopatadine) Side Effects

Cerebral Infarction (3),  Anaphylactoid Reaction (2),  Therapeutic Response Increased (1),  Nasal Discomfort (1),  Abdominal Discomfort (1),  Depression (1),  Eye Pruritus (1),  Osteopenia (1),  Eye Pain (1),  Ocular Hyperaemia (1), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Patanol review by 36 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		Eye allergies
Dosage & duration:		1 drop per eye (dosage frequency: 2 times a day) for the period of 15 days
Other conditions:		Seasonal allergies
Other drugs taken:		Reactine
		Reported Results
Benefits:		I have seasonal allergies and especially in the spring and fall, my eyes itch and get dry. These drops contain anti-histamines that are delivered directly into the eye, and therefore are more effective than just using anti-histamine pills. I think they also helped with the eczema-like flaking on my eyelids but I cannot be sure because I was also using anti-histamine pills at the time.
Side effects:		I did not experience any side effects.
Comments:		These drops really helped with the symptoms but I did wish I could use it more often than just 2 times a day.