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Parnate (Tranylcypromine Sulfate) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Overstimulation which may include increased anxiety, agitation, and manic symptoms is usually evidence of excessive therapeutic action. Dosage should be reduced, or a phenothiazine tranquilizer should be administered concomitantly.

Patients may experience restlessness or insomnia; may notice some weakness, drowsiness, episodes of dizziness or dry mouth; or may report nausea, diarrhea, abdominal pain, or constipation. Most of these effects can be relieved by lowering the dosage or by giving suitable concomitant medication.

Tachycardia, significant anorexia, edema, palpitation, blurred vision, chills, and impotence have each been reported.

Headaches without blood pressure elevation have occurred.

Rare instances of hepatitis, skin rash, and alopecia have been reported.

Impaired water excretion compatible with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) has been reported.

Tinnitus, muscle spasm, tremors, myoclonic jerks, numbness, paresthesia, urinary retention, and retarded ejaculation have been reported.

Hematologic disorders including anemia, leukopenia, agranulocytosis, and thrombocytopenia have been reported.

Post-Introduction Reports

The following are spontaneously reported adverse events temporally associated with use of PARNATE. No clear relationship between PARNATE and these events has been established. Localized scleroderma, flare-up of cystic acne, ataxia, confusion, disorientation, memory loss, urinary frequency, urinary incontinence, urticaria, fissuring in corner of mouth, akinesia.



REPORTS OF SUSPECTED PARNATE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Parnate. The information is not vetted and should not be considered as verified clinical evidence.

Possible Parnate side effects / adverse reactions in 67 year old female

Reported by a consumer/non-health professional from United States on 2011-10-07

Patient: 67 year old female

Reactions: Asthma

Suspect drug(s):
Parnate



Possible Parnate side effects / adverse reactions in 52 year old female

Reported by a consumer/non-health professional from United States on 2011-10-14

Patient: 52 year old female

Reactions: Drug Interaction, Headache, Paraesthesia, Hypertensive Crisis, Food Interaction, Abdominal Discomfort, Feeling Hot, Feeling Abnormal

Suspect drug(s):
Parnate
    Dosage: 50mg per day
    Administration route: Oral
    Indication: Depression
    Start date: 2004-01-01

Proasis
    Dosage: 25mg unknown
    Indication: Energy Increased

Food

Other drugs received by patient: Seroquel



Possible Parnate side effects / adverse reactions in 41 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-01-31

Patient: 41 year old female weighing 81.6 kg (179.5 pounds)

Reactions: Dysarthria, Sedation, Serotonin Syndrome, Gait Disturbance, Feeling Abnormal

Adverse event resulted in: life threatening event

Suspect drug(s):
Parnate
    Administration route: Oral
    Start date: 2011-08-01

Seroquel
    Administration route: Oral
    Start date: 2011-06-20
    End date: 2011-07-28

Seroquel
    Administration route: Oral
    Start date: 2007-05-01
    End date: 2010-03-01

Parnate
    Administration route: Oral
    Indication: Major Depression
    Start date: 2010-12-30

Seroquel
    Administration route: Oral

Seroquel
    Administration route: Oral
    Start date: 2011-06-20
    End date: 2011-07-28

Parnate
    Administration route: Oral
    Start date: 2011-08-01

Seroquel
    Administration route: Oral
    Indication: Depression
    Start date: 2011-07-28

Seroquel
    Administration route: Oral
    Start date: 2007-05-01
    End date: 2010-03-01

Parnate
    Administration route: Oral
    Indication: Depression
    Start date: 2010-12-30

Seroquel
    Administration route: Oral
    Indication: Major Depression
    Start date: 2011-07-28

Seroquel
    Administration route: Oral

Other drugs received by patient: Klonopin; Antidepressants; Lithium Carbonate



See index of all Parnate side effect reports >>

Drug label data at the top of this Page last updated: 2013-01-14

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