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Parlodel (Bromocriptine Mesylate) - Summary

 
 



PARLODEL SUMMARY

Parlodel (bromocriptine mesylate) is an ergot derivative with potent dopamine receptor agonist activity. Each Parlodel (bromocriptine mesylate) SnapTabs tablet for oral administration contains 2 mg and each capsule contains 5 mg bromocriptine (as the mesylate).

Parlodel is indicated for the following:

Hyperprolactinemia -Associated Dysfunctions

Parlodel (bromocriptine mesylate) is indicated for the treatment of dysfunctions associated with hyperprolactinemia including amenorrhea with or without galactorrhea, infertility or hypogonadism. Parlodel treatment is indicated in patients with prolactin -secreting adenomas, which may be the basic underlying endocrinopathy contributing to the above clinical presentations. Reduction in tumor size has been demonstrated in both male and female patients with macroadenomas. In cases where adenectomy is elected, a course of Parlodel therapy may be used to reduce the tumor mass prior to surgery.

Acromegaly

Parlodel therapy is indicated in the treatment of acromegaly. Parlodel therapy, alone or as adjunctive therapy with pituitary irradiation or surgery, reduces serum growth hormone by 50% or more in approximately of patients treated, although not usually to normal levels.

Since the effects of external pituitary radiation may not become maximal for several years, adjunctive therapy with Parlodel offers potential benefit before the effects of irradiation are manifested.

Parkinson's Disease

Parlodel SnapTabs or capsules are indicated in the treatment of the signs and symptoms of idiopathic or postencephalitic Parkinson's disease. As adjunctive treatment to levodopa (alone or with a peripheral decarboxylase inhibitor), Parlodel therapy may provide additional therapeutic benefits in those patients who are currently maintained on optimal dosages of levodopa, those who are beginning to deteriorate (develop tolerance) to levodopa therapy, and those who are experiencing "end of dose failure"’ on levodopa therapy. Parlodel therapy may permit a reduction of the maintenance dose of levodopa and, thus may ameliorate the occurrence and/or severity of adverse reactions associated with long-term levodopa therapy such as abnormal involuntary movements (e.g., dyskinesias) and the marked swings in motor function (“on-off’’ phenomenon). Continued efficacy of Parlodel therapy during treatment of more than 2 years has not been established.

Data are insufficient to evaluate potential benefit from treating newly diagnosed Parkinson's disease with Parlodel. Studies have shown, however, significantly more adverse reactions (notably nausea, hallucinations, confusion and hypotension) in Parlodel-treated patients than in levodopa/carbidopa-treated patients. Patients unresponsive to levodopa are poor candidates for Parlodel therapy.


See all Parlodel indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Parlodel (Bromocriptine)

Randomized clinical trial of quick-release bromocriptine among patients with type 2 diabetes on overall safety and cardiovascular outcomes. [2010.07]
CONCLUSIONS: The frequency of SAEs was comparable between the treatment arms. Compared with patients in the placebo arm, fewer patients taking bromocriptine-QR experienced a cardiovascular end point.

Cabergoline versus bromocriptine for symptomatic treatment of premenstrual mastalgia: a randomised, open-label study. [2010.06]
OBJECTIVE: To compare the effectiveness and side effects of cabergoline with bromocriptine for the symptomatic treatment of cyclic mastalgia as a part of the premenstrual syndrome... CONCLUSIONS: Cabergoline is as effective as bromocriptine for the treatment of cyclic mastalgia but has minimal side effects compared to bromocriptine. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

A comparison of bromocriptine & cabergoline on fertility outcome of hyperprolactinemic infertile women undergoing intrauterine insemination. [2010.05]
BACKGROUND & OBJECTIVES: The aim of this study was to compare the effects of bromocriptine versus cabergoline on pregnancy in hyperprolactinaemic infertile women... CONCLUSION: Our results suggest that cabergoline treatment in infertile women with prolactinemia is more effective. It lowers prolactin with better tolerability and much more effective in the achievement of pregnancy.

Evaluation of bromocriptine in the treatment of acute severe peripartum cardiomyopathy: a proof-of-concept pilot study. [2010.04.06]
CONCLUSIONS: In this trial, the addition of bromocriptine to standard heart failure therapy appeared to improve left ventricular ejection fraction and a composite clinical outcome in women with acute severe PPCM, although the number of patients studied was small and the results cannot be considered definitive. Larger-scale multicenter and blinded studies are in progress to test this strategy more robustly.

Effect of bromocriptine on antipsychotic drug-induced hyperprolactinemia: eight-week randomized, single-blind, placebo-controlled, multicenter study. [2010.02]
AIM: The objective of the present study was to assess the efficacy and safety of bromocriptine treatment for patients with antipsychotic-drug-induced hyperprolactinemia in clinical practice... CONCLUSION: Administration of bromocriptine is a safe method for treating antipsychotic-drug-induced hyperprolactinemia without exacerbating either psychotic symptoms or EPS.

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Clinical Trials Related to Parlodel (Bromocriptine)

Effect of Bromocriptine on Left Ventricular Function in Women With Peripartum Cardiomyopathy [Recruiting]
This is a randomized, controlled clinical trial to evaluate the efficacy and safety of bromocriptine for improvement of left ventricular function of women with Peripartum cardiomyopathy (PPCM). A Multi center trial in Germany.

Pramipexole and Bromocriptine on Nonmotor Symptoms of Early Parkinson's Disease [Recruiting]
The purpose of this study is to determine whether pramipexole and bromocriptine are effective in the treatment of non-motor symptoms in Parkinson's Disease.

Comparing Prism Adaptation Therapy and Bromocriptine Medication for Spatial Neglect: Theoretical and Practical Outcomes [Recruiting]
The purpose of this research study is to examine the effects of prism adaptation or bromocriptine treatment on two visual-spatial recovery components. After a stroke, an "internal GPS", locating where objects or people lie in a particular area of space, may be impaired. Alternately, a stroke may impair precise visual-spatial hand and body aiming movements. The research team wishes to discover whether using prism goggles, or taking a medication (bromocriptine) affects visual-spatial where or aiming errors selectively after stroke.

This research represents one of the first attempts to apply what we know about the brain from neuroscience research, to modern clinical rehabilitation practices.

QR-Bromocriptine as an Adjunct to Insulin and Metformin in the Treatment of Type 2 Diabetes [Recruiting]
QR-Bromocriptine as an add-on treatment to insulin and metformin in the management of type 2 diabetes will result in improved glycemic control, reduced exogenous insulin requirement, increased lean fat mass and improved pancreatic beta-cell function.

Risperidone-Induced Hyperprolactinemia Treated With Bromocriptine [Not yet recruiting]
Antipsychotic drugs can cause a clinically relevant hyperprolactinemia due to blocking the dopamine receptors in the pituitary. Schizophrenic patients suffering from a neuroleptic-induced hyperprolactinemia will be examined endocrinologically. Adverse drug effects and diagnoses will be confirmed by measuring hormones.

more trials >>

Reports of Suspected Parlodel (Bromocriptine) Side Effects

Maternal Exposure During Pregnancy (9)Pathological Gambling (7)Dyspnoea (7)Impulse-Control Disorder (5)Epistaxis (5)Compulsive Shopping (5)Pulmonary Embolism (4)Impulsive Behaviour (4)Somnolence (4)Cardiomegaly (4)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 2 ratings/reviews, Parlodel has an overall score of 8.50. The effectiveness score is 8 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst.
 

Parlodel review by 39 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   High level of Prolactin
Dosage & duration:   1 mg/day taken daily for the period of 2 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   It was effective for the regulation of the prolactin levels and the menstrual periods. The regulation of the ovulation helped achieved pregnancy within a few months.
Side effects:   The only side effect was mild nausea, that could be prevented by eating before taking the medicine in the morning or taking it at bedtime.
Comments:   The use of parlodel to regulate ovulation and prolactin levels for about two years with regular blood tests to check levels of prolactin. After 2 years and a stable level of prolactin, the medicine dose was reduced to half and then completely stopped without increasing the levels of prolactin.

 

Parlodel review by 33 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Psoriatic Arthritis
Dosage & duration:   2.5mg taken daily for the period of 1 year
Other conditions:   midly elevated Prolactin
Other drugs taken:   none
  
Reported Results
Benefits:   IT decreased mildly elevated Prolactin immediately from 25 units to 10 units. (mg/l ?) It also increased my sex drive, but this stopped after a while. It also moderately decreased Psoriatic Arthritis pains and also symptoms in nails and joints, but needed to be taken very regular for this.. Forgetting to take it twice a week already made it work less effective. (Cabergoline was more effective, had less side effects- but potentially has side effects on heart valve, so one needs to be very careful with it. )
Side effects:   Some dyspepsia. This was all the side effects I noticed. I did not like these side effects though and therefore discontinued when the psoriatic arthritis seemed to be under control. When I discontinued Parlodel, I took Cabergoline( with a much longer half life in the body) in a very low dosage to make sure that my Prolactin levels only gradually moved back. I know once I took Parlodel and stopped and then took a Prolactin test 48h later and the levels were higher then without taking any meds. So best is to decrease dosage slowly and not suddenly. I think this is the case with any ergot derivative.
Comments:   Taken for 6 months. Once daily, but half a tablet of 2.5 mg was taken after a while to reduce side effects. I found the best way to get a stable prolactin levels and best improvement was to take half a tablet once in morning and once in evening. I was diagnosed with Psoriatic Arthritis, symptoms were mild, but psorisis was clearly visible on nails. I considered if there was a link between my elevated Prolactin and the psorisis. Found this on the internet and asked doc to prescribe parlodel.

See all Parlodel reviews / ratings >>

Page last updated: 2010-10-05

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