Paraplatin (Carboplatin) - Drug Interactions, Contraindications, Overdosage

DRUG INTERACTIONS

Drug Interactions

The renal effects of nephrotoxic compounds may be potentiated by PARAPLATIN.

OVERDOSAGE

There is no known antidote for PARAPLATIN overdosage. The anticipated complications of overdosage would be secondary to bone marrow suppression and/or hepatic toxicity.

CONTRAINDICATIONS

PARAPLATIN is contraindicated in patients with a history of severe allergic reactions to cisplatin or other platinum-containing compounds, or mannitol.

PARAPLATIN (carboplatin lyophilized powder) for INJECTION should not be employed in patients with severe bone marrow depression or significant bleeding.