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Panixine Disperdose (Cephalexin) - Summary

 
 



SUMMARY

Panixine
DisperDose ®
(cephalexin tablets for oral suspension)

Cephalexin, USP is a semisynthetic cephalosporin antibiotic intended for oral administration. It is 7-(D-α-amino-α-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid monohydrate.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Panixine DisperDose and other antibacterial drugs, Panixine DisperDose should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Cephalexin is indicated for the treatment of the following infections when caused by susceptible strains of the designated microorganisms:

Respiratory tract infections caused by S. pneumoniae and S. pyogenes (Penicillin is the usual drug of choice in the treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever. Cephalexin is generally effective in the eradication of streptococci from the nasopharynx; however, substantial data establishing the efficacy of cephalexin in the subsequent prevention of rheumatic fever are not available at present.)

Otitis media due to S. pneumoniae, H. influenzae, staphylococci, streptococci and M. catarrhalis

Skin and skin structure infections caused by staphylococci and/or streptococci

Bone infections caused by staphylococci and/or P. mirabilis

Genitourinary tract infections, including acute prostatitis, caused by E. coli, P. mirabilis, and K. pneumoniae

Note — Culture and susceptibility tests should be initiated prior to and during therapy. Renal function studies should be performed when indicated.


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NEWS HIGHLIGHTS

Published Studies Related to Panixine Disperdose (Cephalexin)

Randomized controlled trial of cephalexin versus clindamycin for uncomplicated pediatric skin infections. [2011.03]
OBJECTIVE: To compare clindamycin and cephalexin for treatment of uncomplicated skin and soft tissue infections (SSTIs) caused predominantly by community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA). We hypothesized that clindamycin would be superior to cephalexin (an antibiotic without MRSA activity) for treatment of these infections... CONCLUSIONS: There is no significant difference between cephalexin and clindamycin for treatment of uncomplicated pediatric SSTIs caused predominantly by CA-MRSA. Close follow-up and fastidious wound care of appropriately drained, uncomplicated SSTIs are likely more important than initial antibiotic choice.

Effects of sodium bicarbonate and ammonium chloride pre-treatments on PEPT2 (SLC15A2) mediated renal clearance of cephalexin in healthy subjects. [2011]
PEPT2 mediates the H(+) gradient-driving reabsorption of di- and tri-peptides, and various peptidomimetic compounds in the kidney... This effect was more obvious for the PEPT2*2/*2.

Efficacy and tolerability of once-daily cephalexin in canine superficial pyoderma: an open controlled study. [2008.08]
OBJECTIVES: The aims of this study were to evaluate the efficacy and tolerability of oral cephalexin given at 30 mg/kg once daily in dogs with superficial pyoderma and to compare them with those of oral cephalexin given at 15 mg/kg twice daily. METHODS: Twenty dogs with superficial pyoderma were treated with cephalexin at 30 to 60 mg/kg orally once daily (group A) and compared with 20 dogs treated at a dose of 15 to 30 mg/kg orally twice daily (group B)...

randomized, double-blind, placebo-controlled trial of cephalexin for treatment of uncomplicated skin abscesses in a population at risk for community-acquired methicillin-resistant Staphylococcus aureus infection. [2007.11]
Empirical use of beta-lactam antibiotics, the preferred agents for treating uncomplicated skin and soft tissue infections, may no longer be appropriate for these infections because of the increasing prevalence of community strains of methicillin-resistant Staphylococcus aureus (MRSA)...

Randomized, Double-Blind, Placebo-Controlled Trial of Cephalexin for Treatment of Uncomplicated Skin Abscesses in a Population at Risk for Community Methicillin-Resistant Staphylococcus aureus Infection. [2007.09.10]
Background- Empirical use of beta-lactam antibiotics, the preferred agents for treating uncomplicated skin and soft-tissue infections, may no longer be appropriate for these infections because of increasing prevalence of community strains of methicillin-resistant Staphylococcus aureus (MRSA)...

more studies >>

Clinical Trials Related to Panixine Disperdose (Cephalexin)

A Study of the Pharmacokinetics and Pharmacodynamics of MK4618 in Women With Overactive Bladder (MK-4618-004 AM1) [Terminated]
The study is designed to investigate the effects of an investigational drug, MK-4618 on maximum urinary bladder capacity in women with overactive bladder. Overactive bladder is best described as urgency and frequency of urination, with or without involuntary urination and/or the need to awaken during the night to urinate.

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PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 7 ratings/reviews, Panixine Disperdose has an overall score of 8. The effectiveness score is 8 and the side effect score is 7.14. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Panixine Disperdose review by 20 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Skin Infection
Dosage & duration:   500 mg taken 3 times per day for the period of 10 days
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   Treatment of skin infection.
Side effects:   Vaginal yeast infection.
Comments:   Take 1 capsule by mouth three times daily for 10 days.

 

Panixine Disperdose review by care giver of 1 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   streptoccocus:severe sore throat,high fever(104.4)
Dosage & duration:   4ml by mouth (dosage frequency: 3 times a day) for the period of 7 days
Other conditions:   none
Other drugs taken:   one doze of penicilin;occasionally tylenol for fever
  
Reported Results
Benefits:   the baby was totally cured in 7 days
Side effects:   because of the antibiotic several days after appeared a severe yeast infection
Comments:   the baby was sick for 4 days already but her doctor didnt see anything serious.Her fever was already 104.4 and it was difficult to drop it. she couldnt eat nore sleep and was crying days and nights because her throat was very very sore.Finally we took her into emergency room and they found out that she has strep. they gave us cephalexin. the baby felt relief on her 4th day.she started to eat and play. no more fever. in 7 days, by the end of her treatment, she felt wonderful. the only problem was that several days after treatment she started to have an awful yeast infection.I beleive it was the side effect from antibiotic. it took us one more week to treat tha infection. I rated the cephalexin as 8 'cause it took 4 days to feel relief(i think its a lot) and the side effect was quite sufficient too.overall I liked this medicine.

 

Panixine Disperdose review by 38 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   mild local skin infection
Dosage & duration:   500 mg taken 1 x daily for the period of 2 days
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   I cannot say whether this medication was or was not effective because I stopped taking it after 2 doses. I discontinued the medication because the side effects were severe and much worse than the condition prescribed for.
Side effects:   About 24 hours after my second dose I developed sudden acute abdominal pain. I have never had a negative reaction to any medication before, and had rarely had any stomach pain in my life. This pain was so strong and intense almost like the pain of a labor contraction. But alas it was upper abdominal and not coming from my uteris. It came in waves and anything I ate or drank made it worse. I was very close to going to the ER. But since my temp, BP and HR were normal and I did not have any other obvious symptoms I toughed it out with a heating pad and curse words. After 2 days of this torture I finally feel the worst is over. But I will not take this med again.
Comments:   The initial skin infection is clearing up.

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Page last updated: 2011-12-09

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