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Panhematin (Hemin) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

PANHEMATIN drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

OVERDOSAGE

Reversible renal shutdown has been observed in a case where an excessive hematin dose (12.2 mg/kg) was administered in a single infusion. Treatment of this case consisted of ethacrynic acid and mannitol.[ 7 ]

CONTRAINDICATIONS

PANHEMATIN is contraindicated in patients with known hypersensitivity to this drug.

REFERENCES

  1. Bickers, D., Treatment of the Porphyrias: Mechanisms of Action, J Invest Dermatol 77(1):107-113, 1981.
  2. Watson, C. J., Hematin and Porphyria, editorial, N Engl J Med 293(12): 605-607, September 18, 1975.
  3. Lamon, J. M., Hematin Therapy for Acute Porphyria, Medicine 58(3): 252-269, 1979.
  4. Dhar, G J., et al., Effects of Hematin in Hepatic Porphyria, Ann Intern Med 83: 20-30, 1975.
  5. Watson, C. J., et al., Use of Hematin in the Acute Attack of the “Inducible” Hepatic Porphyrias, Adv Intern Med 23: 265-286, 1978.
  6. McColl, K. E., et al., Treatment with Haematin in Acute Hepatic Porphyria, Q J Med, New Series L (198): 161-174, Spring, 1981.
  7. Dhar, G. J., et al., Transitory Renal Failure Following Rapid Administration of a Relatively Large Amount of Hematin in a Patient with Acute Intermittent Porphyria in Clinical Remission, Acta Med Scand 203: 437-443, 1978.
  8. Morris, D.L., et al., Coagulopathy Associated with Hematin Treatment for Acute Intermittent Porphyria, Ann Intern Med 95: 700-701, 1981.
  9. Pierach, C. A., Hematin Therapy for the Porphyric Attack, Semin Liver Dis 2(2): 125-131, May, 1982.

Manufactured by: Fresenius Kabi USA, LLC
Raleigh, NC 27616

For: Recordati Rare Diseases Inc.
Lebanon, NJ 08833, U.S.A.
U.S. Lic. No. 1899

RECORDATI RARE DISEASES GROUP
® Trademark of Recordati Rare Diseases Inc.
Revised: February 2013

750-04243-7

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