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Pancuronium (Pancuronium Bromide) - Summary

 
 



THIS DRUG SHOULD BE ADMINISTERED BY ADEQUATELY TRAINED INDIVIDUALS FAMILIAR WITH ITS ACTIONS, CHARACTERISTICS, AND HAZARDS.

 

PANCURONIUM SUMMARY

Pancuronium
Bromide Injection

Pancuronium Bromide is a nondepolarizing neuromuscular blocking agent chemically designated as the aminosteroid 2β, 16β - dipiperidino-5α-androstane-3α, 17-β diol diacetate dimethobromide, C35H60Br2N2O4.

Pancuronium bromide is indicated as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.


See all Pancuronium indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Pancuronium

Are the cognitive side effects of anesthesia overlooked?
Source: Pain / Anesthetics News From Medical News Today [2014.08.19]
Although guidelines are commonly in place to minimize pain-related side effects of anesthesia, a new survey finds that less attention is paid to the risk of cognitive side effects.

For pediatric knee surgery, regional anesthesia reduces pain, speeds recovery
Source: Bones / Orthopedics News From Medical News Today [2014.08.14]
A recent study of an ultrasound-guided regional anesthesia technique, called femoral nerve block, shows that it leads to less opioid use and allows the majority of patients to go home within hours of...

Potential new treatment for people with PTSD: Xenon exposure shown to erase traumatic memories
Source: Anxiety / Stress News From Medical News Today [2014.08.29]
McLean Hospital researchers are reporting that xenon gas, used in humans for anesthesia and diagnostic imaging, has the potential to be a treatment for post-traumatic stress disorder (PTSD) and other...

Spotlight on nurse anesthetists in Clinical Scholars Review
Source: Nursing / Midwifery News From Medical News Today [2014.06.02]
As a profession, nurse anesthesia is at a tipping point. While recent federal legislation and changes to the U.S.

more news >>

Published Studies Related to Pancuronium

Similar preoperative hemodynamic response to pancuronium and rocuronium in high-risk cardiac surgical patients. [2005.12]
AIM: Rocuronium may be a good alternative to pancuronium in cardiac surgical patients. We evaluate the hemodynamic response to rocuronium and pancuronium administered to cardiac surgical patients... CONCLUSIONS: Rocuronium can be a safe alternative to pancuronium for patients requiring cardiac surgical procedures.

Does pancuronium or cisatracurium delay the rate of arousal following remifentanil-based anesthesia? [2005.10]
STUDY OBJECTIVE: The present report investigates the rate of arousal following remifentanil-based anesthesia associated with the coadministration of pancuronium, which inhibits butyrylcholinesterase, or cisatracurium, which is partially metabolized by nonspecific esterases, versus vecuronium that is eliminated independently of ester hydrolysis... CONCLUSION: The results suggest that recovery following remifentanil-based anesthesia is not delayed by the coadministration of pancuronium, cisatracurium versus vecuronium; and by the use of neostigmine for reversal of neuromuscular blockade.

Interaction between mivacurium and pancuronium: impact of the order of administration. [2005.05]
INTRODUCTION: Potentiation of mivacurium by low-dose pancuronium is mostly due to an inhibition of plasma butyryl cholinesterase (BchE) resulting in a decreased rate of hydrolysis of mivacurium. Nevertheless, an interaction at the receptor site could not be ruled out. By changing the order of the muscle relaxant injections, we may lessen the pharmacokinetic interaction and assess the impact at the acetylcholine receptor level... CONCLUSION: Interaction between mivacurium and low dose pancuronium is significant only when mivacurium is injected after pancuronium.

Myocardial performance index with sevoflurane-pancuronium versus fentanyl-midazolam-pancuronium in infants with a functional single ventricle. [2004.12]
BACKGROUND: Patients with congenital heart disease characterized by a functional single ventricle make up an increasing number of patients presenting for cardiac or noncardiac surgery. Conventional echocardiographic methods to measure left ventricular function, i.e., ejection fraction, are invalid in these patients because of altered ventricular geometry. Two recently described Doppler echocardiographic modalities, the myocardial performance index and Doppler tissue imaging, can be applied to single-ventricle patients because they are independent of ventricular geometry. This study assessed the changes in myocardial performance index and Doppler tissue imaging in response to two anesthetic regimens, fentanyl-midazolam-pancuronium and sevoflurane-pancuronium... CONCLUSIONS: Myocardial performance index, a global measurement of combined systolic and diastolic ventricular function, is not affected by commonly used doses of fentanyl-midazolam or sevoflurane in infants with a functional single ventricle.

Different F-wave recovery after neuromuscular blockade with pancuronium and mivacurium. [2004.11]
We performed this study to assess the recovery period after neuromuscular blockade by electromyographic F-wave analysis, a method that supplies more information about more proximal parts of the motor system than conventionally used methods, e.g., mechanomyography (MMG)...

more studies >>

Clinical Trials Related to Pancuronium

Rapid Infusion of Cold Normal Saline During CPR for Patients With Out-of-hospital Cardiac Arrest [Recruiting]
That paramedic core cooling during CPR using a rapid infusion of ice-cold (4 degrees C) large-volume (30mL/kg) normal saline improves outcome at hospital discharge compared with standard care in patients with out-of-hospital cardiac arrest.

The RINSE Trial: The Rapid Infusion of Cold Normal Saline Trial During Cardiopulmonary Resuscitation (CPR) [Not yet recruiting]
Primary hypothesis to be tested:

In patients with sudden out-of-hospital cardiac arrest, immediate cooling by paramedics using a rapid infusion of cold saline improves outcome at hospital discharge.

Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract Obstructions [Not yet recruiting]
There are two options of fetal treatment in cases of severe lower urinary tract obstructions: the vesico-amniotic shunting and fetal cystoscopy. There is no study confirming the effectiveness of these treatment, specially comparing both techniques. The present study aims to investigate the effectiveness of these treatments.

more trials >>


Page last updated: 2014-08-29

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