Pancuronium Bromide is a nondepolarizing neuromuscular blocking agent chemically designated as the aminosteroid 2β, 16β - dipiperidino-5α-androstane-3α, 17-β diol diacetate dimethobromide, C35H60Br2N2O4.
Pancuronium bromide is indicated as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Media Articles Related to Pancuronium
The Death of Joan Rivers: Endoscopy and Anesthesia Risks
Source: MedicineNet Heart Attack Pathology: Photo Essay Specialty [2014.12.09]
Title: The Death of Joan Rivers: Endoscopy and Anesthesia Risks
Category: Doctor's Views
Created: 9/8/2014 12:00:00 AM
Last Editorial Review: 12/9/2014 12:00:00 AM
Parsing Out Best Practices for Endovascular Thrombectomy (CME/CE)
Source: MedPage Today Surgery [2015.02.16]
(MedPage Today) -- "Time is brain" in endovascular thrombectomy, more evidence against general anesthesia.
Published Studies Related to Pancuronium
Similar preoperative hemodynamic response to pancuronium and rocuronium in high-risk cardiac surgical patients. [2005.12]
AIM: Rocuronium may be a good alternative to pancuronium in cardiac surgical patients. We evaluate the hemodynamic response to rocuronium and pancuronium administered to cardiac surgical patients... CONCLUSIONS: Rocuronium can be a safe alternative to pancuronium for patients requiring cardiac surgical procedures.
Does pancuronium or cisatracurium delay the rate of arousal following remifentanil-based anesthesia? [2005.10]
STUDY OBJECTIVE: The present report investigates the rate of arousal following remifentanil-based anesthesia associated with the coadministration of pancuronium, which inhibits butyrylcholinesterase, or cisatracurium, which is partially metabolized by nonspecific esterases, versus vecuronium that is eliminated independently of ester hydrolysis... CONCLUSION: The results suggest that recovery following remifentanil-based anesthesia is not delayed by the coadministration of pancuronium, cisatracurium versus vecuronium; and by the use of neostigmine for reversal of neuromuscular blockade.
Interaction between mivacurium and pancuronium: impact of the order of administration. [2005.05]
INTRODUCTION: Potentiation of mivacurium by low-dose pancuronium is mostly due to an inhibition of plasma butyryl cholinesterase (BchE) resulting in a decreased rate of hydrolysis of mivacurium. Nevertheless, an interaction at the receptor site could not be ruled out. By changing the order of the muscle relaxant injections, we may lessen the pharmacokinetic interaction and assess the impact at the acetylcholine receptor level... CONCLUSION: Interaction between mivacurium and low dose pancuronium is significant only when mivacurium is injected after pancuronium.
Myocardial performance index with sevoflurane-pancuronium versus fentanyl-midazolam-pancuronium in infants with a functional single ventricle. [2004.12]
BACKGROUND: Patients with congenital heart disease characterized by a functional single ventricle make up an increasing number of patients presenting for cardiac or noncardiac surgery. Conventional echocardiographic methods to measure left ventricular function, i.e., ejection fraction, are invalid in these patients because of altered ventricular geometry. Two recently described Doppler echocardiographic modalities, the myocardial performance index and Doppler tissue imaging, can be applied to single-ventricle patients because they are independent of ventricular geometry. This study assessed the changes in myocardial performance index and Doppler tissue imaging in response to two anesthetic regimens, fentanyl-midazolam-pancuronium and sevoflurane-pancuronium... CONCLUSIONS: Myocardial performance index, a global measurement of combined systolic and diastolic ventricular function, is not affected by commonly used doses of fentanyl-midazolam or sevoflurane in infants with a functional single ventricle.
Different F-wave recovery after neuromuscular blockade with pancuronium and mivacurium. [2004.11]
We performed this study to assess the recovery period after neuromuscular blockade by electromyographic F-wave analysis, a method that supplies more information about more proximal parts of the motor system than conventionally used methods, e.g., mechanomyography (MMG)...
Clinical Trials Related to Pancuronium
The RINSE Trial: The Rapid Infusion of Cold Normal Saline Trial During Cardiopulmonary Resuscitation (CPR) [Not yet recruiting]
Primary hypothesis to be tested:
In patients with sudden out-of-hospital cardiac arrest, immediate cooling by paramedics
using a rapid infusion of cold saline improves outcome at hospital discharge.
Rapid Infusion of Cold Normal Saline During CPR for Patients With Out-of-hospital Cardiac Arrest [Recruiting]
That paramedic core cooling during CPR using a rapid infusion of ice-cold (4 degrees C)
large-volume (30mL/kg) normal saline improves outcome at hospital discharge compared with
standard care in patients with out-of-hospital cardiac arrest.
Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract Obstructions [Not yet recruiting]
There are two options of fetal treatment in cases of severe lower urinary tract
obstructions: the vesico-amniotic shunting and fetal cystoscopy. There is no study
confirming the effectiveness of these treatment, specially comparing both techniques. The
present study aims to investigate the effectiveness of these treatments.