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Panafil (Papain / Urea / Chlorophyllin Topical) - Description and Clinical Pharmacology



PANAFIL Ointment is an enzymatic healing-debriding ointment which contains papain, USP (not less than 521,700 USP units of activity per gram); urea, USP 10%; and chlorophyllin copper complex sodium, USP 0.5% in a hydrophilic base composed of boric acid, chlorobutanol (anhydrous) as a preservative, polyoxyl 40 stearate, propylene glycol, purified water, sodium borate, sorbitanmonostearate, stearyl alcohol, and white petrolatum.


Papain, the proteolytic enzyme derived from the fruit of carica papaya, is a potent digestant of nonviable protein matter, but is harmless to viable tissue. It has the unique advantage of being active over a wide pH range, 3 to 12. Despite its recognized value as a digestive agent, papain is relatively ineffective when used alone as a debriding agent, primarily because it requires the presence of activators to exert its digestive function. Urea is combined with papain to provide two supplementary chemical actions: 1) to expose by solvent action the activators of papain (sulfhydryl groups) which are always present, but not necessarily accessible, in the nonviable tissue or debris of lesions, and 2) to denature the nonviable protein matter in lesions and thereby render it more susceptible to enzymatic digestion. In pharmacologic studies involving digestion of beef powder, Miller1 showed that the combination of papain and urea produced twice as much digestion as papain alone.

Chlorophyllin Copper Complex Sodium adds healing action to the cleansing action of the proteolytic papain-urea combination. The basic wound-healing properties of Chlorophyllin Copper Complex Sodium are promotion of healthy granulations, control of local inflammation and reduction of wound odors. 2 Specifically, Chlorophyllin Copper Complex Sodium inhibits the hemagglutinating and inflammatory properties of protein degradation products in the wound, including the products of enzymatic digestion, thus providing an additional protective factor.1,3 The incorporation of Chlorophyllin Copper Complex Sodium in PANAFIL Ointment permits its continuous use for as long as desired to help produce and then maintain a clean wound base and to promote healing.

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