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Pamine (Methscopolamine Bromide) - Summary

 
 



PAMINE SUMMARY

Pamine® 2.5 mg/Pamine® Forte 5 mg

Pamine® 2.5 mg/Pamine® Forte 5 mg Tablets contain methscopolamine bromide, an anticholinergic, which occurs as white crystals, or as a white odorless crystalline powder. Methscopolamine bromide melts at about 225°C with decomposition. The drug is freely soluble in water, slightly soluble in alcohol, and insoluble in acetone and in chloroform.

PAMINE (METHSCOPOLAMINE) is indicated for the following:

Adjunctive therapy for the treatment of peptic ulcer.

METHSCOPOLAMINE BROMIDE HAS NOT BEEN SHOWN TO BE EFFECTIVE IN CONTRIBUTING TO THE HEALING OF PEPTIC ULCER, DECREASING THE RATE OF RECURRENCE OR PREVENTING COMPLICATIONS.


See all Pamine indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Pamine (Methscopolamine)

Marijuana use may reduce dopamine in the brain
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2016.04.15]
Dopamine is an important neurotransmitter, but a new study finds that heavy marijuana use could lower its release, causing negative effects on learning and behavior.

Dopamine key to vocal learning, songbird study finds
Source: Hearing / Deafness News From Medical News Today [2016.03.16]
The neurotransmitter dopamine is essential to correcting vocal mistakes, suggests a study on Bengalese finches.

Research shows certain genes, in healthy environments, can lengthen lifespan
Source: Genetics News From Medical News Today [2016.04.25]
Researchers at the University at Buffalo Research Institute on Addictions have discovered how a gene in the brain's dopamine system can play an important role in prolonging lifespan: it must be...

New principle for brain-controlled hormone secretion
Source: Endocrinology News From Medical News Today [2016.04.14]
The concentration of the hormone prolactin in the blood is controlled by dopamine.

Disproving hypothesis clears path for research for new treatment options for schizophrenia
Source: Schizophrenia News From Medical News Today [2016.03.11]
Researchers reported results from the first repeated-dose study of a dopamine-1 receptor (D1R) agonist for treating the cognitive and negative symptoms of schizophrenia yesterday in the Journal of...

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Published Studies Related to Pamine (Methscopolamine)

Methscopolamine bromide blocks hypothalamic-stimulated release of growth hormone in ewes. [1997.05]
Twenty-five nonlactating ewes were used to test the hypothesis that methscopolamine bromide (MB) blocks secretion of growth hormone (GH) by affecting hypothalamic rather than pituitary mechanisms. Ewes were randomly assigned to receive a s.c...

The muscarine antagonist methscopolamine and the NMDA antagonist AP-5 injected unilaterally into the nucleus accumbens cause mice to rotate in opposite directions. [1995]
Previously, we have reported that the NMDA antagonist AP-5, injected unilaterally into the nucleus accumbens of mice, induces ipsilateral rotation in monoaminergically intact mice, but contralateral rotation in monoamine-depleted animals. In this paper we report that the muscarine antagonist methscopolamine, injected unilaterally into the nucleus accumbens, induced predominantly contralateral rotation in monoaminergically intact mice...

Dorsal striatal mechanisms involved in the dopamine D2 receptor-mediated potentiation of apomorphine-induced jaw movements. [1994.01.24]
The role of dorsal striatal mechanisms in the regulation of apomorphine-induced jaw movements was studied. Jaw movements induced by apomorphine (0.2 mg/kg i.v.) were potentiated by quinpirole (10 micrograms/0.2 microliter) injected into the dorsal part of the striatum 10 min before apomorphine...

Seizure promotion by D1 agonists does not correlate with other dopaminergic properties. [1993]
A range of D1 receptor agonists were tested for their ability to facilitate limbic motor seizures induced by a subthreshold dose of the chemoconvulsant pilocarpine (100 mg/kg IP) in mice. ED50 values (mumol/kg) were calculated from log dose-probit analyses, giving relative proconvulsant potencies of SKF 82958 > CY 208-243 > SKF 77434 = SKF 75670 = SKF 80723 > SKF 38393...

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Page last updated: 2016-04-25

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