Pamelor®
(nortriptyline HCl) capsules, USP
(nortriptyline HCl) oral solution, USP
Rx only
DESCRIPTION
Pamelor® (nortriptyline HCl) is 1-Propanamine, 3-(10,11-dihydro- 5H -dibenzo[ a,d ] cyclohepten-5-ylidene)- N -methyl-, hydrochloride.
The structural formula is as follows:
10 mg, 25 mg, 50 mg, and 75 mg Capsules
Active Ingredient: nortriptyline hydrochloride USP.
10 mg, 25 mg, and 75 mg Capsules
Inactive Ingredients: D&C Yellow #10, FD&C Yellow #6, gelatin, silicone fluid, starch, and titanium dioxide.
50 mg Capsules
Inactive Ingredients: gelatin, silicone fluid, starch, and titanium dioxide.
Solution
Active Ingredient: nortriptyline hydrochloride USP.
Inactive Ingredients: alcohol, benzoic acid, flavoring, purified water, and sorbitol.
|
CLINICAL PHARMACOLOGY
The mechanism of mood elevation by tricyclic antidepressants is at present unknown. Pamelor® (nortriptyline HCl) is not a monoamine oxidase inhibitor. It inhibits the activity of such diverse agents as histamine, 5-hydroxytryptamine, and acetylcholine. It increases the pressor effect of norepinephrine but blocks the pressor response of phenethylamine. Studies suggest that Pamelor® (nortriptyline HCl) interferes with the transport, release, and storage of catecholamines. Operant conditioning techniques in rats and pigeons suggest that Pamelor® (nortriptyline HCl) has a combination of stimulant and depressant properties.
|
