Oxyir (Oxycodone Hydrochloride) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

The most frequently observed reactions include light-headedness, dizziness, sedation, nausea, and vomiting. These effects seem to be more prominent in ambulatory than in nonambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down. Many of these adverse events will cease or decrease in intensity as oxycodone therapy is continued and some degree of tolerance is developed.

Other adverse reactions include euphoria, dysphoria, constipation, skin rash and pruritus.

DRUG ABUSE AND DEPENDENCE (ADDICTION)

Oxycodone products are common targets for both drug abusers and drug addicts.

Drug addiction (drug dependence, psychological dependence) is characterized by a preoccupation with the procurement, hoarding, and abuse of drugs for non-medicinal purposes. Drug dependence is treatable, utilizing a multi-disciplinary approach, but relapse is common. Iatrogenic "addiction" to opioids legitimately used in the management of pain is very rare. "Drug seeking" behavior is very common to addicts. Tolerance and physical dependence in pain patients are not signs of psychological dependence. Preoccupation with achieving adequate pain relief can be appropriate behavior in a patient with poor pain control. Most chronic pain patients limit their intake of opioids to achieve a balance between the benefits of the drug and dose-limiting side effects. Physicians should be aware that psychological dependence may not be accompanied by concurrent tolerance and symptoms of physical dependence in all addicts. In addition, abuse of opioids can occur in the absence of true psychological dependence and is characterized by misuse for non-medical purposes, often in combination with other psychoactive substances.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO OXYIR

Possible Oxyir side effects / adverse reactions in 63 year old male

Reported by a individual with unspecified qualification on 2007-03-09

Patient: 63 year old male

Reactions: Neoplasm Malignant

Adverse event resulted in: death

Suspect drug(s):
Oxyir

Possible Oxyir side effects / adverse reactions in 63 year old male

Reported by a individual with unspecified qualification from United States on 2007-03-20

Patient: 63 year old male

Reactions: non-Small Cell Lung Cancer

Adverse event resulted in: death

Suspect drug(s):
Oxyir

Other drugs received by patient: Duragesic-100

Possible Oxyir side effects / adverse reactions in 50 year old male

Reported by a physician from United States on 2007-03-30

Patient: 50 year old male

Reactions: Vomiting, Nausea, Gastroenteritis, Drug Withdrawal Syndrome

Adverse event resulted in: hospitalization

Suspect drug(s):
Oxyir
    Dosage: unk, unk
    Indication: Pain
    Start date: 1996-01-01

Oxycodone HCL
    Indication: Pain
    Start date: 2006-07-06

Fentanyl
    Dosage: 800 mcg, prn
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    Start date: 2005-11-18
    End date: 2006-02-01

Hydrocodone
    Dosage: unk, unk
    Indication: Drug USE FOR Unknown Indication
    Start date: 2006-10-04

Other drugs received by patient: Verapamil; Rosiglitazone; Metformin; Aciphex; Lisinopril; Esomeprazole Magnesium; Duloxetine; Lovastatin