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Oxyir (Oxycodone Hydrochloride) - Summary

 
 



OXYIR SUMMARY

Oxycodone is an opioid analgesic.

For the relief of moderate to moderately severe pain.


See all Oxyir indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Oxyir (Oxycodone)

Oxycodone overdose deaths drop 25 percent after launch of Prescgram
Source: Pain / Anesthetics News From Medical News Today [2015.04.17]
Oxycodone-related deaths dropped 25 percent after Florida implemented its Prescription Drug Monitoring Program in late 2011 as part of its response to the state's prescription drug abuse epidemic...

National Drop in Opioid Prescriptions, Overdose
Source: Medscape Psychiatry & Mental Health Headlines [2015.04.21]
After the introduction of abuse-deterrent formulations of oxycodone and the withdrawal of propoxyphene from the market, there has been a drop in opioid prescriptions and prescription opioid overdose.
Medscape Medical News

Ultrasound First, Not CT, for Women's Pelvic Pain
Source: Medscape Emergency Medicine Headlines [2015.04.22]
Research backs ultrasound for its lack of radiation, lower cost, and reliable results, but CT is often the go-to choice.
Medscape Medical News

Caterpillar fungus could hold the key to relieving the pain of osteoarthritis
Source: Arthritis / Rheumatology News From Medical News Today [2015.04.22]
A drug from a parasitic mushroom that lives on caterpillars could become an effective new painkiller for people with osteoarthritis within the next six years, according to UK researchers.

World-first MRI study shows babies experience pain 'like adults'
Source: MRI / PET / Ultrasound News From Medical News Today [2015.04.21]
Researchers have discovered that babies feel pain in much the same way as adults, leading to experts recommending a review of neonatal pain management practice.

more news >>

Published Studies Related to Oxyir (Oxycodone)

Comparison of subjective effects of extended-release versus immediate-release oxycodone/acetaminophen tablets in healthy nondependent recreational users of prescription opioids: a randomized trial. [2014]
[APAP]) formulation with those of immediate-release (IR) OC/APAP... CONCLUSIONS: Extended-release OC/APAP produced lower subjective drug effects than

A randomized, double-blind, placebo-controlled study of oral oxycodone plus acetaminophen for the treatment of pain in photodynamic therapy on port wine stains. [2014]
efficacy and safety of an oral analgesic for the treatment of pain in PDT on PWS... CONCLUSIONS: The time of the pain beginning was 8.31 ± 4.58 min in

Bowel function after tapentadol and oxycodone immediate release (IR) treatment in patients with low back or osteoarthritis pain. [2013]
OBJECTIVES: Constipation is a common side effect of opioid therapy. Tapentadol immediate release (IR) was better tolerated than oxycodone IR in 2 clinical trials involving patients with low back or osteoarthritis pain... DISCUSSION: Patient-reported bowel function associated with tapentadol IR treatment was similar to that associated with placebo (10-d trial) and significantly better than that associated with oxycodone IR treatment (10- and 90-d trials).

Diclofenac with or without an antiemetic for acute migraine headaches in adults. [2013]
CONCLUSIONS: Oral diclofenac potassium 50 mg is an effective treatment

Comparison of the efficacy and safety of dual-opioid treatment with morphine plus oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after total knee arthroplasty. [2013]
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose

more studies >>

Clinical Trials Related to Oxyir (Oxycodone)

Oxycodone for Labor Pain - Pharmacokinetics (PK), Safety and Efficacy [Not yet recruiting]
Childbirth is one of the most painful events that a woman is likely to experience, and thus is a major concern for most parturient. Severe pain releases stress mediators and may thus compromise fetus well-being if placental perfusion is decreased. Epidural analgesia is the golden standard for the management of severe labor pain. However, it could not always be used both due the parturient related factors and the organizational reasons. However, the knowledge on safety and efficacy of oxycodone involving mother, fetus and newborn is limited.

Aim of the study is firstly, to evaluate the efficacy and safety of oxycodone in labor pain healthy parturients. Secondly, to measure parturient's blood oxycodone concentration during labour and fetal concentration from placental umbilical vein and artery right after birth.

Oxycodone-Naloxone Prolonged Release Tablets in Relieving Opioid-Related Constipation [Active, not recruiting]

Oxycodone-Naloxone in Relieving Opioid-Related Constipation [Active, not recruiting]
The primary objective of this study is to demonstrate that subjects with moderate to severe non-malignant pain taking oxycodone/naloxone prolonged release tablets have improvement in symptoms of constipation compared to subjects taking oxycodone prolonged release tablets alone.

Open-Label Trial Comparing Oxycodone Medications [Recruiting]
The investigators hypothesize that subjects will have greater pain relief when taking IR-oxycodone compared with ER-oxycodone for several reasons. The ability to take a varying amount of medication at six different points over the course of a day will allow patients to take as much (or as little) medication as they need to control their pain. In addition, the ability to vary the medication doses in this way will give them a greater sense of control, which will also contribute to greater pain relief. Similarly, the investigators predict that patients will show greater benefits with IR-oxycodone on the measures of physical and emotional functioning. Because there is relatively little data on sleep apnea in chronic pain patients (Webster et al., 2008), these assessments are exploratory and not hypothesis-based. Finally, although it is typically thought that the abuse liability of IR-opioid medications is greater than for ER-medications, the data on which this belief are based have not involved systematic studies of patients with chronic pain; the assessments of abuse liability will therefore also be exploratory.

Pharmacokinetics And Relative Bioavailability Study Of Oxycodone in Healthy Volunteers [Recruiting]
To estimate the pharmacokinetics and relative bioavailability of oxycodone after administration of 40 mg doses of PF-00345439 formulations taken whole under fed conditions and after chewing under fasted conditions in healthy volunteers

more trials >>


Page last updated: 2015-04-22

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