DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Oxyir (Oxycodone Hydrochloride) - Summary

 
 



OXYIR SUMMARY

Oxycodone is an opioid analgesic.

For the relief of moderate to moderately severe pain.


See all Oxyir indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Oxyir (Oxycodone)

Dramatic increase reported in opioid prescriptions during emergency department visits over the last decade
Source: Pain / Anesthetics News From Medical News Today [2014.03.17]
George Washington University (GW) researchers report dramatic increases in prescriptions of opioid analgesics, such as Percocet, Vicodin, oxycodone and Dilaudid, during U.S.

Getting in Front of Back Pain
Source: Yahoo Health News [2014.04.12]
SATURDAY, April 12, 2014 (HealthDay News) -- Even though back pain affects nearly 10 million Americans a year, there's a lot you can do to avoid the problem, an expert says. It begins with healthy habits, including not smoking along with maintaini...

14th Annual Strategic Project and Portfolio Management for Pharma, 26-28 January 2015, Spain
Source: Conferences News From Medical News Today [2014.04.11]
14th Annual Strategic Project and Portfolio Management for Pharma, 26-28 January 2015, SpainThe 14th Annual Conference on Strategic Project & Portfolio Management for Pharma will look at how...

Scripps Florida Scientists win grant to study how exposure to prescription pain medication in the womb affects developing brain
Source: Pregnancy / Obstetrics News From Medical News Today [2014.04.11]
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded a $472,500 Cutting Edge Basic Research Award (CEBRA) by the National Institute on Drug Abuse (NIDA) of...

A Young Woman With Unilateral Eye Pain and Erythema
Source: Medscape Ophthalmology Headlines [2014.04.10]
A 30-year-old woman presents with right eye pain, air and light sensitivity, and redness. What is your differential diagnosis, and what would you do next?
Medscape Ophthalmology

more news >>

Published Studies Related to Oxyir (Oxycodone)

Tolerability and efficacy of two synergistic ratios of oral morphine and oxycodone combinations versus morphine in patients with chronic noncancer pain. [2012]
SETTING: Clinical study centers in Australia... CONCLUSION: A 3:2 or 1:2 fixed ratio combination of morphine and oxycodone (MOX)

Liver cancer: effects, safety, and cost-effectiveness of controlled-release oxycodone for pain control after TACE. [2012]
liver cancer who are undergoing transarterial chemoembolization... CONCLUSION: CRO is effective, safe, and cost-effective in the control of

A randomized, double-blind, active-controlled, double-dummy, parallel-group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate/severe, chronic cancer pain. [2012]
prolonged-release tablets (OxyPR) in patients with moderate/severe cancer pain... CONCLUSIONS: OXN PR provides superior bowel function in cancer pain patients,

Oxycodone lengthens reproductions of suprasecond time intervals in human research volunteers. [2011.08]
Oxycodone, a popularly used opioid for treating pain, is widely abused. Other drugs of abuse have been shown to affect time perception, which, in turn, may affect sensitivity to future consequences.

Clinical outcomes during opioid titration following initiation with or conversion to Remoxy(R), an extended-release formulation of oxycodone. [2011.07]
Intra- and interpatient variability in opioid response usually necessitates opioid therapy titration to optimally balance analgesia and side effects, whether initiating therapy or converting from another opioid. Remoxy(R) (King Pharmaceuticals, Inc., Bristol, TN, which was acquired by Pfizer Inc in March 2011) is an extended-release formulation of oxycodone designed to maintain its rate-controlling mechanism following physical and chemical manipulation...

more studies >>

Clinical Trials Related to Oxyir (Oxycodone)

Oxycodone for Labor Pain - Pharmacokinetics (PK), Safety and Efficacy [Not yet recruiting]
Childbirth is one of the most painful events that a woman is likely to experience, and thus is a major concern for most parturient. Severe pain releases stress mediators and may thus compromise fetus well-being if placental perfusion is decreased. Epidural analgesia is the golden standard for the management of severe labor pain. However, it could not always be used both due the parturient related factors and the organizational reasons. However, the knowledge on safety and efficacy of oxycodone involving mother, fetus and newborn is limited.

Aim of the study is firstly, to evaluate the efficacy and safety of oxycodone in labor pain healthy parturients. Secondly, to measure parturient's blood oxycodone concentration during labour and fetal concentration from placental umbilical vein and artery right after birth.

Comparison of the Efficacy of Oral Oxycodone and Oral Codeine in the Treatment of Postcraniotomy Pain [Recruiting]
The efficacy of codeine is dependent on its demethylation to morphine. This extent of demethylation has wide inter-individual variability, making codeine's efficacy as a analgesic variable. Oxycodone is a semi-synthetic opioid and is a weak agonist on mu opioid receptors.

Codeine has been the mainstay of analgesia for patients after craniotomy for many years. Traditionally, craniotomies were not thought to be very painful procedures, hence the use of codeine, a moderately potent opioid (when compared to morphine).

However, in recent years, it has been found that up to 70% of post-craniotomy patients have moderate to severe pain and codeine did not provide adequate analgesic relief. Many studies have compared codeine to other drugs such as PCA morphine, fentanyl and tramadol, and patients on these stronger opioids generally had lower pain scores and better satisfaction.

No study has been conducted to determine the efficacy of analgesia of oral oxycodone to oral codeine.

Hence, the hypothesis is that oxycodone is more effective than codeine in providing pain relief in post-craniotomy patients.

Oxycodone-Naloxone Prolonged Release Tablets in Relieving Opioid-Related Constipation [Active, not recruiting]

Oxycodone-Naloxone in Relieving Opioid-Related Constipation [Active, not recruiting]
The primary objective of this study is to demonstrate that subjects with moderate to severe non-malignant pain taking oxycodone/naloxone prolonged release tablets have improvement in symptoms of constipation compared to subjects taking oxycodone prolonged release tablets alone.

Open-Label Trial Comparing Oxycodone Medications [Recruiting]
The investigators hypothesize that subjects will have greater pain relief when taking IR-oxycodone compared with ER-oxycodone for several reasons. The ability to take a varying amount of medication at six different points over the course of a day will allow patients to take as much (or as little) medication as they need to control their pain. In addition, the ability to vary the medication doses in this way will give them a greater sense of control, which will also contribute to greater pain relief. Similarly, the investigators predict that patients will show greater benefits with IR-oxycodone on the measures of physical and emotional functioning. Because there is relatively little data on sleep apnea in chronic pain patients (Webster et al., 2008), these assessments are exploratory and not hypothesis-based. Finally, although it is typically thought that the abuse liability of IR-opioid medications is greater than for ER-medications, the data on which this belief are based have not involved systematic studies of patients with chronic pain; the assessments of abuse liability will therefore also be exploratory.

more trials >>


Page last updated: 2014-04-12

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2012