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Oxycontin (Oxycodone Hydrochloride) - Summary

 

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WARNING:

OxyContin is an opioid agonist and a Schedule II controlled substance with an abuse liability similar to morphine.

Oxycodone can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing OxyContin in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion.

OxyContin Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous, around-the-clock analgesic is needed for an extended period of time.

OxyContin Tablets are NOT intended for use as a prn analgesic.

OxyContin 80 mg and 160 mg Tablets ARE FOR USE IN OPIOID-TOLERANT PATIENTS ONLY. These tablet strengths may cause fatal respiratory depression when administered to patients not previously exposed to opioids.

OxyContin TABLETS ARE TO BE SWALLOWED WHOLE AND ARE NOT TO BE BROKEN, CHEWED, OR CRUSHED. TAKING BROKEN, CHEWED, OR CRUSHED OxyContin TABLETS LEADS TO RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE OF OXYCODONE.

 

OXYCONTIN SUMMARY

OXYCONTIN®
(OXYCODONE HCL CONTROLLED-RELEASE) TABLETS CII
10 mg 20 mg 40 mg 80 mg* 160 mg*

OxyContin® (oxycodone hydrochloride controlled-release) Tablets are an opioid analgesic supplied in 10 mg, 20 mg, 40 mg, 80 mg, and 160 mg tablet strengths for oral administration. The tablet strengths describe the amount of oxycodone per tablet as the hydrochloride salt.

OxyContin Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous, around-the-clock analgesic is needed for an extended period of time.

OxyContin is NOT intended for use as a prn analgesic.

Physicians should individualize treatment in every case, initiating therapy at the appropriate point along a progression from non-opioid analgesics, such as non-steroidal anti-inflammatory drugs and acetaminophen to opioids in a plan of pain management such as outlined by the World Health Organization, the Agency for Healthcare Research and Quality (formerly known as the Agency for Health Care Policy and Research), the Federation of State Medical Boards Model Guidelines, or the American Pain Society.

OxyContin is not indicated for pain in the immediate postoperative period (the first 12-24 hours following surgery), or if the pain is mild, or not expected to persist for an extended period of time. OxyContin is only indicated for postoperative use if the patient is already receiving the drug prior to surgery or if the postoperative pain is expected to be moderate to severe and persist for an extended period of time. Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate. (See American Pain Society guidelines.)

OxyContin® is a mu-agonist opioid with an abuse liability similar to morphine and is a Schedule II controlled substance. Oxycodone, like morphine and other opioids used in analgesia, can be abused and is subject to criminal diversion.

OXYCONTIN NEWS HIGHLIGHTS

Media Articles Related to Oxycontin (Oxycodone)

FDA Panel Nixes 'Abuse-Proof' OxyContin
Source: MedicineNet oxycodone Specialty [2008.05.07]

OxyContin (oxycodone) Questions and Answers
Source: MedicineNet oxycodone and acetaminophen Specialty [2007.06.11]

Nearly Half Of US Adults Will Develop Painful Knee Osteoarthritis By Age 85: Study
Source: Arthritis / Rheumatology News From Medical News Today [2008.09.03]

1,500 Professionals From The Biotechnology Sector Will Participate In Biospain 2008
Source: Conferences News From Medical News Today [2008.09.02]

Diamyd Medical: Diamyd Medical's NTDDS Technology Effective Against Diabetes Pain
Source: Diabetes News From Medical News Today [2008.09.02]

more>>

Published Studies Related to Oxycontin (Oxycodone)

The effect of single-dose tramadol on oxycodone clearance. [2007.11]

Postoperative intravenous morphine consumption, pain scores, and side effects with perioperative oral controlled-release oxycodone after lumbar discectomy. [2007.07]

Efficacy and tolerability of once-daily OROS hydromorphone and twice-daily extended-release oxycodone in patients with chronic, moderate to severe osteoarthritis pain: results of a 6-week, randomized, open-label, noninferiority analysis. [2007.05]

PTI-821: sustained-release oxycodone using gel-cap technology. [2007.03]

A randomized, open-label, multicenter trial comparing once-a-day AVINZA (morphine sulfate extended-release capsules) versus twice-a-day OxyContin (oxycodone hydrochloride controlled-release tablets) for the treatment of chronic, moderate to severe low back pain: improved physical functioning in the ACTION trial. [2007.01]

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Clinical Trials Related to Oxycontin (Oxycodone)

Oxycodone-Naloxone Prolonged Release Tablets in Relieving Opioid-Related Constipation [Active, not recruiting]

Oxycodone-Naloxone in Relieving Opioid-Related Constipation [Active, not recruiting]

Oxycodone and Pregabalin for the Treatment of Oncological Neuropathic Pain [Recruiting]

Study of the Abuse Liability of Oxycodone HCl/Niacin in Subjects With a History of Opioid Abuse [Recruiting]

A Study Of RN624 (PF-04383119) And Oxycodone In Patients With Pain Due To Cancer That Has Spread To Bone [Recruiting]

more>>

Page last updated: 2008-09-03

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