WARNING:
OxyContin contains oxycodone which is an opioid agonist and a Schedule II controlled substance with an abuse liability similar to morphine.
OxyContin can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing OxyContin in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion.
OxyContin Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.
OxyContin Tablets are not intended for use on an as needed basis.
Patients considered opioid tolerant are those who are taking at least 60 mg oral morphine/day, 25 mcg transdermal fentanyl/hour, 30 mg oral oxycodone/day, 8 mg oral hydromorphone/day, 25 mg oral oxymorphone/day, or an equianalgesic dose of another opioid for one week or longer.
OxyContin 60 mg, 80 mg, and 160 mg Tablets, a single dose greater than 40 mg, or a total daily dose greater than 80 mg are only for use in opioid-tolerant patients, as they may cause fatal respiratory depression when administered to patients who are not tolerant to the respiratory-depressant or sedating effects of opioids.
Persons at increased risk for opioid abuse include those with a personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression). Patients should be assessed for their clinical risks for opioid abuse or addiction prior to being prescribed opioids. All patients receiving opioids should be routinely monitored for signs of misuse, abuse and addiction.
OxyContin must be swallowed whole and must not be cut, broken, chewed, crushed or dissolved. Taking cut, broken, chewed, crushed or dissolved OxyContin tablets leads to rapid release and absorption of a potentially fatal dose of oxycodone.
The concomitant use of OxyContin with all cytochrome P450 3A4 inhibitors such as macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), and protease inhibitors (e.g., ritonavir) may result in an increase in oxycodone plasma concentrations, which could increase or prolong adverse effects and may cause potentially fatal respiratory depression. Patients receiving OxyContin and a CYP3A4 inhibitor should be carefully monitored for an extended period of time and dosage adjustments should be made if warranted.
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OXYCONTIN SUMMARY
OxyContin® (oxycodone hydrochloride controlled-release) Tablets are an opioid analgesic supplied in 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg, and 160 mg tablet strengths for oral administration. The tablet strengths describe the amount of oxycodone per tablet as the hydrochloride salt.
OxyContin Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.
OxyContin is not intended for use on an as needed basis.
Physicians should individualize treatment in every case, initiating therapy at the appropriate point along a progression from non-opioid analgesics, such as non-steroidal anti-inflammatory drugs and acetaminophen to opioids in a plan of pain management such as outlined by the World Health Organization, the Agency for Healthcare Research and Quality (formerly known as the Agency for HealthCare Policy and Research), the Federation of State Medical Boards Model Guidelines, or the American Pain Society.
OxyContin is not indicated for pain in the immediate postoperative period (the first 12-24 hours following surgery), or if the pain is mild, or not expected to persist for an extended period of time. OxyContin is only indicated for postoperative use if the patient is already receiving the drug prior to surgery or if the postoperative pain is expected to be moderate to severe and persist for an extended period of time. Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate. (See American Pain Society guidelines.)
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NEWS HIGHLIGHTSMedia Articles Related to Oxycontin (Oxycodone)
The Opioid Crisis and Need for Compassion in Pain Management
Source: Medscape Anesthesiology Headlines [2017.09.28]
In this commentary, the author expresses concern that the response to the public health crisis of opioid addiction is creating a growing crisis of inadequate pain management.
American Journal of Public Health
CVS to Restrict Opioid Painkiller Prescription Amounts
Source: MedicineNet Drug Abuse Specialty [2017.09.25]
Title: CVS to Restrict Opioid Painkiller Prescription Amounts
Category: Health News
Created: 9/22/2017 12:00:00 AM
Last Editorial Review: 9/25/2017 12:00:00 AM
Stomach Pain Quiz: Nausea & Other Causes
Source: MedicineNet Anal Fissure Specialty [2017.09.19]
Title: Stomach Pain Quiz: Nausea & Other Causes
Category: MedicineNet Quiz
Created: 1/20/2011 12:00:00 AM
Last Editorial Review: 9/19/2017 5:59:56 PM
Back Pain Quiz: Test Your Back Pain IQ
Source: MedicineNet Ankylosing Spondylitis Specialty [2017.09.19]
Title: Back Pain Quiz: Test Your Back Pain IQ
Category: MedicineNet Quiz
Created: 6/16/2011 3:41:00 PM
Last Editorial Review: 9/19/2017 6:39:04 PM
Pain Quiz: Test Your IQ of Pain
Source: MedicineNet Constipation Specialty [2017.09.19]
Title: Pain Quiz: Test Your IQ of Pain
Category: MedicineNet Quiz
Created: 7/14/2011 3:53:00 PM
Last Editorial Review: 9/19/2017 6:41:41 PM
Published Studies Related to Oxycontin (Oxycodone)
Comparison of subjective effects of extended-release versus immediate-release
oxycodone/acetaminophen tablets in healthy nondependent recreational users of
prescription opioids: a randomized trial. [2014]
[APAP]) formulation with those of immediate-release (IR) OC/APAP... CONCLUSIONS: Extended-release OC/APAP produced lower subjective drug effects than
A randomized, double-blind, placebo-controlled study of oral oxycodone plus
acetaminophen for the treatment of pain in photodynamic therapy on port wine
stains. [2014]
efficacy and safety of an oral analgesic for the treatment of pain in PDT on PWS... CONCLUSIONS: The time of the pain beginning was 8.31 ± 4.58 min in
Safety and efficacy of once-daily hydromorphone extended-release versus
twice-daily oxycodone hydrochloride controlled-release in chinese patients with
cancer pain: a phase 3, randomized, double-blind, multicenter study. [2014]
Noninferiority of the efficacy of once-daily hydromorphone hydrochloride
extended-release (hydromorphone ER) compared with twice-daily oxycodone
hydrochloride controlled-release (oxycodone CR) was investigated in this
randomized, double-blind study in Chinese patients with moderate to severe cancer
pain requiring strong oral opioid analgesics.
Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate
in acute bone fracture pain control: a double-blind placebo-controlled randomized
clinical trial. [2014]
control efforts efficacy and decrease the adverse effects of each medication... CONCLUSION: Intravenous acetaminophen plus oral oxycodone is as effective as
Bowel function after tapentadol and oxycodone immediate release (IR) treatment in
patients with low back or osteoarthritis pain. [2013]
OBJECTIVES: Constipation is a common side effect of opioid therapy. Tapentadol
immediate release (IR) was better tolerated than oxycodone IR in 2 clinical
trials involving patients with low back or osteoarthritis pain... DISCUSSION: Patient-reported bowel function associated with tapentadol IR
treatment was similar to that associated with placebo (10-d trial) and
significantly better than that associated with oxycodone IR treatment (10- and
90-d trials).
Clinical Trials Related to Oxycontin (Oxycodone)
Pharmacokinetics Study of ALO-02 and OxyContin [Completed]
To characterize the single- and multiple-dose pharmacokinetics of oxycodone following the
administration of ALO-02 40 Mg Twice Daily, ALO-02 80 Mg Once Daily or Oxycontin 40 Mg Twice
Daily in Healthy Volunteers
Early Postoperative Administration of Oxycodone +/- Naloxone and Duration of Epidural Analgesia [Not yet recruiting]
Cystectomy with urinary diversion (ileal conduit, ileal orthotopic neobladder,
catheterizable ileal pouch) is major abdominal surgery, which is associated with a high
incidence of gastrointestinal complications. Perioperative techniques aiming at an early
return of bowel function are to be pursued.
Optimal postoperative pain management is one of the key factors leading to enhanced recovery
after surgery. The perioperative use of an epidural analgesia for major abdominal surgery is
established, not only because of its excellent analgesic properties, but also because it can
accelerate the return of bowel function. However, epidural analgesia is associated with
additional costs, need for close monitoring and nursing. In addition each supplemental day
with an indwelling epidural catheter increases the risk of infection. So it is recommended
to re-assess the risk/benefit ratio of an epidural analgesia after 4 days, if not sooner.
Therefore, it is important to develop strategies that reduce its duration without impairing
the benefits. Systemic analgesics with prolonged-release oral formulation like oral
oxycodone (Oxycontin®) or combined drug mixture (oral oxycodone/naloxone (Targin®)) could be
a valuable alternative pain treatment as a second analgesic step, starting on postoperative
day (POD) 3, so that the epidural catheter could be removed earlier without impairing
postoperative enhanced recovery including return of the bowel function. Both oxycodone and
naloxone orally administered are a recognized and accepted treatment option.
The objective of this study is to evaluate the implementation of an oral opioid with or
without naloxone in the early postoperative period in patients undergoing open radical
cystectomy with urinary diversion and intraoperative and early postoperative use of epidural
analgesia. The investigators expect an unchanged early return of the bowel function and
equal analgesia with a reduced length of stay of the epidural catheter (primary endpoint),
thus potentially reducing epidural catheter associated complications and lowering costs
(nursing and pain service).
Study of PF614 Compared to OxyContin® in Healthy Volunteers [Not yet recruiting]
Pharmacokinetics And Relative Bioavailability Study Of Oxycodone [Completed]
A Study to Evaluate Efficacy and Safety of Oxycodone/Naloxone Compared to OxyContin in Korean Cancer Patients [Completed]
Objectives:
To prove non-inferiority of Targin compared to Oxycontin in terms of reduction of pain
intensity
1. Primary objective: Actual reduction of pain intensity (0-10) score (average pain over
24 hours obtained each evening) within 4 weeks
2. Secondary objectives: Bowel Habit (worsening/no change/improving), Total dose and
frequency of rescue medication, Quality of Life (QOL; EORTC QLQ-C30), Duration to need
of laxative use and Adverse events, Long term safety and efficacy
Reports of Suspected Oxycontin (Oxycodone) Side Effects
Drug Dependence (154),
Pain (142),
Drug Withdrawal Syndrome (101),
Vomiting (75),
Substance Abuse (68),
Nausea (65),
Drug Abuse (60),
Death (58),
Suicidal Ideation (56),
Depression (53), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 9 ratings/reviews, Oxycontin has an overall score of 6.56. The effectiveness score is 8.67 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Oxycontin review by 47 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | kidney stones |
| Dosage & duration: | | 5 to 30 mg per day taken 1 to 4 times per day for the period of 8 weeks |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | pain was relieved and could sleep with ease |
| Side effects: | | weight loss irritability when trying to cut back. i currently take a dose of 7.5 to 10 mg per day and would like to continue same dosage |
| Comments: | | after kidney stone i was prescribed oxycodone in a small dose of 7.5 mg for up to 6 times a day. i cut back to 2 times a day after 3 weeks and now just take about 7.5 to 10 mg per day once a day. |
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| | Oxycontin review by 34 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | pain control |
| Dosage & duration: | | 10 mg taken 2-3 times a day depending on pain for the period of 3 weeks |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | The treatment benefits were considerable as OxyContin reduced my pain considerably. In the beginning I was advized to take the drug 1 hour before the previous one wore off as it can take up to 1 hour for it to work. The pain however always did go away and therefore relieving me of it and making me feel comfortable again. |
| Side effects: | | After using the drug for a while I was becoming more and more dependant on it. Therefore I was becomming addicted to this drug as I was depending on it to relieve my pain. I also noticed that while taking this drug I was becoming constipated where in the past that has never been an issue for me. |
| Comments: | | This medication was prescribed to me following my knee arthroplasty. I had a surgery done on my knee where the joints have been replaced. following the surgery I had severe pain and so the doctor as opposed to morphine prescribed OxyContin. I was taking this drug 3 times a day and later 2 to 3 times depending on my pain. The drug worked very well and I was satisfied with it. |
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| | Oxycontin review by 56 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | pain after surgery |
| Dosage & duration: | | 10mg taken every 6 hours for the period of 1 day |
| Other conditions: | | brusing and swelling |
| Other drugs taken: | | Ibuprofen | | |
Reported Results |
| Benefits: | | The drug was prescribed for pain, and it worked to dull post op pain. |
| Side effects: | | The drug made me terribly constipated, which in my opinion, negated the value of the drug. The strain to eliminate was very painful considering the recent surgery. |
| Comments: | | After 1 day of oxycontin and the ensuing constipation, I switched to 800 mg of ibuprofen. While not as effective for the pain, the constipation was alleviated. Overall, the ibuprofen was better for me. |
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Page last updated: 2017-09-28
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