Oxycontin (Oxycodone Hydrochloride) - Summary

OXYCONTIN SUMMARY

OXYCONTIN^®
(OXYCODONE HCL CONTROLLED-RELEASE) TABLETS CII
10 mg 20 mg 40 mg 80 mg* 160 mg*

OxyContin^® (oxycodone hydrochloride controlled-release) Tablets are an opioid analgesic supplied in 10 mg, 20 mg, 40 mg, 80 mg, and 160 mg tablet strengths for oral administration. The tablet strengths describe the amount of oxycodone per tablet as the hydrochloride salt.

OxyContin Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous, around-the-clock analgesic is needed for an extended period of time.

OxyContin is NOT intended for use as a prn analgesic.

Physicians should individualize treatment in every case, initiating therapy at the appropriate point along a progression from non-opioid analgesics, such as non-steroidal anti-inflammatory drugs and acetaminophen to opioids in a plan of pain management such as outlined by the World Health Organization, the Agency for Healthcare Research and Quality (formerly known as the Agency for Health Care Policy and Research), the Federation of State Medical Boards Model Guidelines, or the American Pain Society.

OxyContin is not indicated for pain in the immediate postoperative period (the first 12-24 hours following surgery), or if the pain is mild, or not expected to persist for an extended period of time. OxyContin is only indicated for postoperative use if the patient is already receiving the drug prior to surgery or if the postoperative pain is expected to be moderate to severe and persist for an extended period of time. Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate. (See American Pain Society guidelines.)

OxyContin^® is a mu-agonist opioid with an abuse liability similar to morphine and is a Schedule II controlled substance. Oxycodone, like morphine and other opioids used in analgesia, can be abused and is subject to criminal diversion.

See all Oxycontin indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Oxycontin (Oxycodone)

Reformulated OxyContin To Receive Abuse-Deterrent Labelling
Source: Pain / Anesthetics News From Medical News Today [2013.04.17]
A new reformulated form of Oxycontin (a highly addictive oxycodone hydrochloride) has received a unique labeling update by the U.S. Food and Drug Administration regarding its abuse potential. People most commonly abuse Oxycontin by injecting or snorting it. However, with Purdue Pharma L.P.'s new reformulated version, abuse is much harder. OxyContin abuse is a huge problem in the U.S...

FDA Approves 'Abuse-Deterrent' Label for New Oxycontin
Source: MedicineNet oxycodone Specialty [2013.04.17]
Title: FDA Approves 'Abuse-Deterrent' Label for New Oxycontin
Category: Health News
Created: 4/16/2013 8:36:00 PM
Last Editorial Review: 4/17/2013 12:00:00 AM

'Abuse-Resistant' Oxycontin May Be Driving Addicts to Heroin
Source: MedicineNet oxycodone Specialty [2012.07.12]
Title: 'Abuse-Resistant' Oxycontin May Be Driving Addicts to Heroin
Category: Health News
Created: 7/11/2012 6:05:00 PM
Last Editorial Review: 7/12/2012 12:00:00 AM

Erectile Dysfunction Tied To Long Term Painkiller Use
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2013.05.16]
A new study suggests that long term use of opioid prescription painkillers for back pain is tied to a higher risk of erectile dysfunction (ED). The findings are published in the 15 May online issue of the journal Spine. Lead author Richard A...

Painkillers Increase Risk of Erectile Dysfunction
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2013.05.15]
Regularly taking prescription painkillers, commonly called opioids, is linked to a greater risk of erectile dysfunction (ED) in men, according to a new study published in Spine. Over 11,000 men suffering from back pain were involved in the research...

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Published Studies Related to Oxycontin (Oxycodone)

Tolerability and efficacy of two synergistic ratios of oral morphine and oxycodone combinations versus morphine in patients with chronic noncancer pain. [2012]
SETTING: Clinical study centers in Australia... CONCLUSION: A 3:2 or 1:2 fixed ratio combination of morphine and oxycodone (MOX)

Liver cancer: effects, safety, and cost-effectiveness of controlled-release oxycodone for pain control after TACE. [2012]
liver cancer who are undergoing transarterial chemoembolization... CONCLUSION: CRO is effective, safe, and cost-effective in the control of

A randomized, double-blind, active-controlled, double-dummy, parallel-group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate/severe, chronic cancer pain. [2012]
prolonged-release tablets (OxyPR) in patients with moderate/severe cancer pain... CONCLUSIONS: OXN PR provides superior bowel function in cancer pain patients,

Oxycodone lengthens reproductions of suprasecond time intervals in human research volunteers. [2011.08]
Oxycodone, a popularly used opioid for treating pain, is widely abused. Other drugs of abuse have been shown to affect time perception, which, in turn, may affect sensitivity to future consequences.

Clinical outcomes during opioid titration following initiation with or conversion to Remoxy(R), an extended-release formulation of oxycodone. [2011.07]
Intra- and interpatient variability in opioid response usually necessitates opioid therapy titration to optimally balance analgesia and side effects, whether initiating therapy or converting from another opioid. Remoxy(R) (King Pharmaceuticals, Inc., Bristol, TN, which was acquired by Pfizer Inc in March 2011) is an extended-release formulation of oxycodone designed to maintain its rate-controlling mechanism following physical and chemical manipulation...

more studies >>

Clinical Trials Related to Oxycontin (Oxycodone)

Oxycodone for Labor Pain - Pharmacokinetics (PK), Safety and Efficacy [Not yet recruiting]
Childbirth is one of the most painful events that a woman is likely to experience, and thus is a major concern for most parturient. Severe pain releases stress mediators and may thus compromise fetus well-being if placental perfusion is decreased. Epidural analgesia is the golden standard for the management of severe labor pain. However, it could not always be used both due the parturient related factors and the organizational reasons. However, the knowledge on safety and efficacy of oxycodone involving mother, fetus and newborn is limited.

Aim of the study is firstly, to evaluate the efficacy and safety of oxycodone in labor pain healthy parturients. Secondly, to measure parturient's blood oxycodone concentration during labour and fetal concentration from placental umbilical vein and artery right after birth.

Comparison of the Efficacy of Oral Oxycodone and Oral Codeine in the Treatment of Postcraniotomy Pain [Recruiting]
The efficacy of codeine is dependent on its demethylation to morphine. This extent of demethylation has wide inter-individual variability, making codeine's efficacy as a analgesic variable. Oxycodone is a semi-synthetic opioid and is a weak agonist on mu opioid receptors.

Codeine has been the mainstay of analgesia for patients after craniotomy for many years. Traditionally, craniotomies were not thought to be very painful procedures, hence the use of codeine, a moderately potent opioid (when compared to morphine).

However, in recent years, it has been found that up to 70% of post-craniotomy patients have moderate to severe pain and codeine did not provide adequate analgesic relief. Many studies have compared codeine to other drugs such as PCA morphine, fentanyl and tramadol, and patients on these stronger opioids generally had lower pain scores and better satisfaction.

No study has been conducted to determine the efficacy of analgesia of oral oxycodone to oral codeine.

Hence, the hypothesis is that oxycodone is more effective than codeine in providing pain relief in post-craniotomy patients.

Oxycodone-Naloxone Prolonged Release Tablets in Relieving Opioid-Related Constipation [Active, not recruiting]

Oxycodone-Naloxone in Relieving Opioid-Related Constipation [Active, not recruiting]
The primary objective of this study is to demonstrate that subjects with moderate to severe non-malignant pain taking oxycodone/naloxone prolonged release tablets have improvement in symptoms of constipation compared to subjects taking oxycodone prolonged release tablets alone.

Open-Label Trial Comparing Oxycodone Medications [Recruiting]
The investigators hypothesize that subjects will have greater pain relief when taking IR-oxycodone compared with ER-oxycodone for several reasons. The ability to take a varying amount of medication at six different points over the course of a day will allow patients to take as much (or as little) medication as they need to control their pain. In addition, the ability to vary the medication doses in this way will give them a greater sense of control, which will also contribute to greater pain relief. Similarly, the investigators predict that patients will show greater benefits with IR-oxycodone on the measures of physical and emotional functioning. Because there is relatively little data on sleep apnea in chronic pain patients (Webster et al., 2008), these assessments are exploratory and not hypothesis-based. Finally, although it is typically thought that the abuse liability of IR-opioid medications is greater than for ER-medications, the data on which this belief are based have not involved systematic studies of patients with chronic pain; the assessments of abuse liability will therefore also be exploratory.

more trials >>

Reports of Suspected Oxycontin (Oxycodone) Side Effects

Drug Dependence (154),  Pain (142),  Drug Withdrawal Syndrome (101),  Vomiting (75),  Substance Abuse (68),  Nausea (65),  Drug Abuse (60),  Death (58),  Suicidal Ideation (56),  Depression (53), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Oxycontin review by 47 year old male patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		kidney stones
Dosage & duration:		5 to 30 mg per day taken 1 to 4 times per day for the period of 8 weeks
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		pain was relieved and could sleep with ease
Side effects:		weight loss irritability when trying to cut back. i currently take a dose of 7.5 to 10 mg per day and would like to continue same dosage
Comments:		after kidney stone i was prescribed oxycodone in a small dose of 7.5 mg for up to 6 times a day. i cut back to 2 times a day after 3 weeks and now just take about 7.5 to 10 mg per day once a day.

Oxycontin review by 34 year old male patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		pain control
Dosage & duration:		10 mg taken 2-3 times a day depending on pain for the period of 3 weeks
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		The treatment benefits were considerable as OxyContin reduced my pain considerably. In the beginning I was advized to take the drug 1 hour before the previous one wore off as it can take up to 1 hour for it to work. The pain however always did go away and therefore relieving me of it and making me feel comfortable again.
Side effects:		After using the drug for a while I was becoming more and more dependant on it. Therefore I was becomming addicted to this drug as I was depending on it to relieve my pain. I also noticed that while taking this drug I was becoming constipated where in the past that has never been an issue for me.
Comments:		This medication was prescribed to me following my knee arthroplasty. I had a surgery done on my knee where the joints have been replaced. following the surgery I had severe pain and so the doctor as opposed to morphine prescribed OxyContin. I was taking this drug 3 times a day and later 2 to 3 times depending on my pain. The drug worked very well and I was satisfied with it.

Oxycontin review by 56 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Extremely Severe Side Effects
		Treatment Info
Condition / reason:		pain after surgery
Dosage & duration:		10mg taken every 6 hours for the period of 1 day
Other conditions:		brusing and swelling
Other drugs taken:		Ibuprofen
		Reported Results
Benefits:		The drug was prescribed for pain, and it worked to dull post op pain.
Side effects:		The drug made me terribly constipated, which in my opinion, negated the value of the drug. The strain to eliminate was very painful considering the recent surgery.
Comments:		After 1 day of oxycontin and the ensuing constipation, I switched to 800 mg of ibuprofen. While not as effective for the pain, the constipation was alleviated. Overall, the ibuprofen was better for me.