DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Oxycontin (Oxycodone Hydrochloride) - Summary

 
 



WARNING:

OxyContin is an opioid agonist and a Schedule II controlled substance with an abuse liability similar to morphine.

Oxycodone can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing OxyContin in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion.

OxyContin Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous, around-the-clock analgesic is needed for an extended period of time.

OxyContin Tablets are NOT intended for use as a prn analgesic.

OxyContin 80 mg and 160 mg Tablets ARE FOR USE IN OPIOID-TOLERANT PATIENTS ONLY. These tablet strengths may cause fatal respiratory depression when administered to patients not previously exposed to opioids.

OxyContin TABLETS ARE TO BE SWALLOWED WHOLE AND ARE NOT TO BE BROKEN, CHEWED, OR CRUSHED. TAKING BROKEN, CHEWED, OR CRUSHED OxyContin TABLETS LEADS TO RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE OF OXYCODONE.

 

OXYCONTIN SUMMARY

OXYCONTIN®
(OXYCODONE HCL CONTROLLED-RELEASE) TABLETS CII
10 mg 20 mg 40 mg 80 mg* 160 mg*

OxyContin® (oxycodone hydrochloride controlled-release) Tablets are an opioid analgesic supplied in 10 mg, 20 mg, 40 mg, 80 mg, and 160 mg tablet strengths for oral administration. The tablet strengths describe the amount of oxycodone per tablet as the hydrochloride salt.

OxyContin Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous, around-the-clock analgesic is needed for an extended period of time.

OxyContin is NOT intended for use as a prn analgesic.

Physicians should individualize treatment in every case, initiating therapy at the appropriate point along a progression from non-opioid analgesics, such as non-steroidal anti-inflammatory drugs and acetaminophen to opioids in a plan of pain management such as outlined by the World Health Organization, the Agency for Healthcare Research and Quality (formerly known as the Agency for Health Care Policy and Research), the Federation of State Medical Boards Model Guidelines, or the American Pain Society.

OxyContin is not indicated for pain in the immediate postoperative period (the first 12-24 hours following surgery), or if the pain is mild, or not expected to persist for an extended period of time. OxyContin is only indicated for postoperative use if the patient is already receiving the drug prior to surgery or if the postoperative pain is expected to be moderate to severe and persist for an extended period of time. Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate. (See American Pain Society guidelines.)

OxyContin® is a mu-agonist opioid with an abuse liability similar to morphine and is a Schedule II controlled substance. Oxycodone, like morphine and other opioids used in analgesia, can be abused and is subject to criminal diversion.


See all Oxycontin indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Oxycontin (Oxycodone)

Data presented at NANS 2014 demonstrate long-term, low back pain relief with Spectra Spinal Cord Stimulator System
Source: Medical Devices / Diagnostics News From Medical News Today [2014.12.20]
New retrospective data evaluating the Boston Scientific Corporation (NYSE: BSX) Precision Spectra™ Spinal Cord Stimulator (SCS) System demonstrate that the device provided sustained, highly...

Novel agent decreases neuropathic pain in patients with type 2 diabetes
Source: Diabetes News From Medical News Today [2014.12.19]
Molecular Medicine, a peer-reviewed biomedical journal published by the Feinstein Institute Press, published the results of a new study reporting clinically significant pain reduction in type 2...

The difficulties of treating shoulder pain in baseball pitchers
Source: Bones / Orthopedics News From Medical News Today [2014.12.15]
Results of treating shoulder pain in baseball pitchers and other throwing athletes are not as predictable as doctors, patients and coaches would like to think, according to a report in the journal...

Commonly prescribed painkiller not effective in controlling lower back pain
Source: Seniors / Aging News From Medical News Today [2014.12.15]
A new study in the journal Neurology shows that pregabalin is not effective in controlling the pain associated with lumbar spinal stenosis, the most common type of chronic lower back pain in older...

Painful Hands, Hurting Hearts?
Source: MedPage Today Rheumatology [2014.12.15]
(MedPage Today) -- Symptomatic hand osteoarthritis was linked with coronary heart disease.

more news >>

Published Studies Related to Oxycontin (Oxycodone)

Comparison of subjective effects of extended-release versus immediate-release oxycodone/acetaminophen tablets in healthy nondependent recreational users of prescription opioids: a randomized trial. [2014]
[APAP]) formulation with those of immediate-release (IR) OC/APAP... CONCLUSIONS: Extended-release OC/APAP produced lower subjective drug effects than

A randomized, double-blind, placebo-controlled study of oral oxycodone plus acetaminophen for the treatment of pain in photodynamic therapy on port wine stains. [2014]
efficacy and safety of an oral analgesic for the treatment of pain in PDT on PWS... CONCLUSIONS: The time of the pain beginning was 8.31 ± 4.58 min in

Bowel function after tapentadol and oxycodone immediate release (IR) treatment in patients with low back or osteoarthritis pain. [2013]
OBJECTIVES: Constipation is a common side effect of opioid therapy. Tapentadol immediate release (IR) was better tolerated than oxycodone IR in 2 clinical trials involving patients with low back or osteoarthritis pain... DISCUSSION: Patient-reported bowel function associated with tapentadol IR treatment was similar to that associated with placebo (10-d trial) and significantly better than that associated with oxycodone IR treatment (10- and 90-d trials).

Diclofenac with or without an antiemetic for acute migraine headaches in adults. [2013]
CONCLUSIONS: Oral diclofenac potassium 50 mg is an effective treatment

Comparison of the efficacy and safety of dual-opioid treatment with morphine plus oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after total knee arthroplasty. [2013]
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose

more studies >>

Clinical Trials Related to Oxycontin (Oxycodone)

Oxycodone for Labor Pain - Pharmacokinetics (PK), Safety and Efficacy [Not yet recruiting]
Childbirth is one of the most painful events that a woman is likely to experience, and thus is a major concern for most parturient. Severe pain releases stress mediators and may thus compromise fetus well-being if placental perfusion is decreased. Epidural analgesia is the golden standard for the management of severe labor pain. However, it could not always be used both due the parturient related factors and the organizational reasons. However, the knowledge on safety and efficacy of oxycodone involving mother, fetus and newborn is limited.

Aim of the study is firstly, to evaluate the efficacy and safety of oxycodone in labor pain healthy parturients. Secondly, to measure parturient's blood oxycodone concentration during labour and fetal concentration from placental umbilical vein and artery right after birth.

Oxycodone-Naloxone Prolonged Release Tablets in Relieving Opioid-Related Constipation [Active, not recruiting]

Oxycodone-Naloxone in Relieving Opioid-Related Constipation [Active, not recruiting]
The primary objective of this study is to demonstrate that subjects with moderate to severe non-malignant pain taking oxycodone/naloxone prolonged release tablets have improvement in symptoms of constipation compared to subjects taking oxycodone prolonged release tablets alone.

Open-Label Trial Comparing Oxycodone Medications [Recruiting]
The investigators hypothesize that subjects will have greater pain relief when taking IR-oxycodone compared with ER-oxycodone for several reasons. The ability to take a varying amount of medication at six different points over the course of a day will allow patients to take as much (or as little) medication as they need to control their pain. In addition, the ability to vary the medication doses in this way will give them a greater sense of control, which will also contribute to greater pain relief. Similarly, the investigators predict that patients will show greater benefits with IR-oxycodone on the measures of physical and emotional functioning. Because there is relatively little data on sleep apnea in chronic pain patients (Webster et al., 2008), these assessments are exploratory and not hypothesis-based. Finally, although it is typically thought that the abuse liability of IR-opioid medications is greater than for ER-medications, the data on which this belief are based have not involved systematic studies of patients with chronic pain; the assessments of abuse liability will therefore also be exploratory.

Pharmacokinetics And Relative Bioavailability Study Of Oxycodone in Healthy Volunteers [Recruiting]
To estimate the pharmacokinetics and relative bioavailability of oxycodone after administration of 40 mg doses of PF-00345439 formulations taken whole under fed conditions and after chewing under fasted conditions in healthy volunteers

more trials >>

Reports of Suspected Oxycontin (Oxycodone) Side Effects

Drug Dependence (154)Pain (142)Drug Withdrawal Syndrome (101)Vomiting (75)Substance Abuse (68)Nausea (65)Drug Abuse (60)Death (58)Suicidal Ideation (56)Depression (53)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 9 ratings/reviews, Oxycontin has an overall score of 6.56. The effectiveness score is 8.67 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Oxycontin review by 47 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   kidney stones
Dosage & duration:   5 to 30 mg per day taken 1 to 4 times per day for the period of 8 weeks
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   pain was relieved and could sleep with ease
Side effects:   weight loss irritability when trying to cut back. i currently take a dose of 7.5 to 10 mg per day and would like to continue same dosage
Comments:   after kidney stone i was prescribed oxycodone in a small dose of 7.5 mg for up to 6 times a day. i cut back to 2 times a day after 3 weeks and now just take about 7.5 to 10 mg per day once a day.

 

Oxycontin review by 34 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   pain control
Dosage & duration:   10 mg taken 2-3 times a day depending on pain for the period of 3 weeks
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   The treatment benefits were considerable as OxyContin reduced my pain considerably. In the beginning I was advized to take the drug 1 hour before the previous one wore off as it can take up to 1 hour for it to work. The pain however always did go away and therefore relieving me of it and making me feel comfortable again.
Side effects:   After using the drug for a while I was becoming more and more dependant on it. Therefore I was becomming addicted to this drug as I was depending on it to relieve my pain. I also noticed that while taking this drug I was becoming constipated where in the past that has never been an issue for me.
Comments:   This medication was prescribed to me following my knee arthroplasty. I had a surgery done on my knee where the joints have been replaced. following the surgery I had severe pain and so the doctor as opposed to morphine prescribed OxyContin. I was taking this drug 3 times a day and later 2 to 3 times depending on my pain. The drug worked very well and I was satisfied with it.

 

Oxycontin review by 56 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   pain after surgery
Dosage & duration:   10mg taken every 6 hours for the period of 1 day
Other conditions:   brusing and swelling
Other drugs taken:   Ibuprofen
  
Reported Results
Benefits:   The drug was prescribed for pain, and it worked to dull post op pain.
Side effects:   The drug made me terribly constipated, which in my opinion, negated the value of the drug. The strain to eliminate was very painful considering the recent surgery.
Comments:   After 1 day of oxycontin and the ensuing constipation, I switched to 800 mg of ibuprofen. While not as effective for the pain, the constipation was alleviated. Overall, the ibuprofen was better for me.

See all Oxycontin reviews / ratings >>

Page last updated: 2014-12-20

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2014