Oxycontin (Oxycodone Hydrochloride) - Summary

OXYCONTIN SUMMARY

OXYCONTIN^®
(OXYCODONE HCL CONTROLLED-RELEASE) TABLETS CII
10 mg 20 mg 40 mg 80 mg* 160 mg*

OxyContin^® (oxycodone hydrochloride controlled-release) Tablets are an opioid analgesic supplied in 10 mg, 20 mg, 40 mg, 80 mg, and 160 mg tablet strengths for oral administration. The tablet strengths describe the amount of oxycodone per tablet as the hydrochloride salt.

OxyContin Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous, around-the-clock analgesic is needed for an extended period of time.

OxyContin is NOT intended for use as a prn analgesic.

Physicians should individualize treatment in every case, initiating therapy at the appropriate point along a progression from non-opioid analgesics, such as non-steroidal anti-inflammatory drugs and acetaminophen to opioids in a plan of pain management such as outlined by the World Health Organization, the Agency for Healthcare Research and Quality (formerly known as the Agency for Health Care Policy and Research), the Federation of State Medical Boards Model Guidelines, or the American Pain Society.

OxyContin is not indicated for pain in the immediate postoperative period (the first 12-24 hours following surgery), or if the pain is mild, or not expected to persist for an extended period of time. OxyContin is only indicated for postoperative use if the patient is already receiving the drug prior to surgery or if the postoperative pain is expected to be moderate to severe and persist for an extended period of time. Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate. (See American Pain Society guidelines.)

OxyContin^® is a mu-agonist opioid with an abuse liability similar to morphine and is a Schedule II controlled substance. Oxycodone, like morphine and other opioids used in analgesia, can be abused and is subject to criminal diversion.

See all indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Oxycontin (Oxycodone)

Phosphagenics Announces Positive Results From Phase 1B Study Of Transdermal Oxycodone Patch
Source: Pain / Anesthetics News From Medical News Today [2010.02.03]
Phosphagenics Limited ("Phosphagenics") (ASX: POH; OTCQX: PPGNY) today announced positive results from a Phase 1B clinical study using the Company's patented TPM™ (Targeted Penetration Matrix) for the transdermal delivery of oxycodone...

Oxycodone Linked to Rise in Opioid-Related Deaths
Source: MedicineNet codeine Specialty [2009.12.10]
Title: Oxycodone Linked to Rise in Opioid-Related Deaths
Category: Health News
Created: 12/9/2009 12:10:00 PM
Last Editorial Review: 12/10/2009

Oxycodone May Reduce Shingles Pain
Source: MedicineNet Chickenpox (Varicella) Specialty [2009.04.13]
Title: Oxycodone May Reduce Shingles Pain
Category: Health News
Created: 4/11/2009 2:00:00 AM
Last Editorial Review: 4/13/2009

Celebrating 30 Years Of Innovation In Neuromodulation, St. Jude Medical Unveils Latest Product At American Academy Of Pain Medicine Annual Meeting
Source: Health News from Medical News Today [2010.02.04]
St. Jude Medical, Inc. (NYSE:STJ) today announced the U.S. Food and Drug Administration (FDA) clearance of the Swift-Lock(TM) anchor, a new product designed to help physicians efficiently secure neurostimulation leads utilized in spinal cord stimulation (SCS) therapy for the management of chronic pain. Introduced at the American Academy of Pain Medicine (AAPM) annual meeting, the Swift-Lock anchor builds on a 30-year history of developing industry-leading neurostimulation products...

SOMA 250 MG Shown To Significantly Improve Functionality And Reduce Disability In Patients With Low Back Pain In Three Days
Source: Clinical Trials / Drug Trials News From Medical News Today [2010.02.04]
A recent analysis of two pivotal clinical trials in patients with acute low back pain (ALBP) who were treated with SOMA® (carisoprodol) 250 mg showed significantly improved functionality and reduced disability after three days of treatment, as measured by the Roland-Morris Disability Questionnaire (RMDQ)...

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Published Studies Related to Oxycontin (Oxycodone)

Dexamethasone decreases oxycodone consumption following osteotomy of the first metatarsal bone: a randomized controlled trial in day surgery. [2009.10.10]
Background: Dexamethasone may improve multimodal pain management following painful orthopedic day surgery procedures, and decrease the need for post-operative opioids. We hypothesized that dexamethasone would reduce the need for oxycodone after surgical correction of hallux valgus... Conclusion: Oral dexamethasone combined with paracetamol significantly reduced total oxycodone consumption following surgical correction of hallux valgus.

A comparison of intravenous oxycodone and intravenous morphine in patient-controlled postoperative analgesia after laparoscopic hysterectomy. [2009.10]
INTRODUCTION: In this study, we investigated the dose requirements, pain relief, and side effects of oxycodone versus morphine after surgery with visceral pain... CONCLUSIONS: Oxycodone was more potent than morphine for visceral pain relief but not for sedation.

Analgesic efficacy of peripheral kappa-opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective effect on visceral pain. [2009.09]
BACKGROUND: Peripherally selective opioids may be beneficial in visceral pain management due to absence of centrally mediated side effects. The objectives of this study were: (1) to assess the effects of a peripherally selective tetrapeptide kappa-opioid receptor agonist, CR665, on experimental pain from multi-modal stimulation of skin, muscle, and viscera, and (2) contrast these effects with those of oxycodone (centrally acting opioid)... CONCLUSION: CR665 had a selective effect on visceral pain. Oxycodone exhibited a generalized effect, elevating thresholds for cutaneous, deep somatic, and visceral pain stimulation.

Relationship between rate of infusion and reinforcing strength of oxycodone in humans. [2009.07]
The rate of drug delivery to the central nervous system is believed to be an important predictor of the reinforcing strength of a drug. However, only a few studies have directly examined the relationship between drug-taking behavior and rate of drug administration... Specifically, these "abuse-deterrent formulations" could prevent patients from tampering with their medications to enhance their euphoric and reinforcing effects.

Rifampin greatly reduces the plasma concentrations of intravenous and oral oxycodone. [2009.06]
BACKGROUND: Oxycodone is a mu-opioid receptor agonist that is metabolized mainly in the liver by cytochrome P450 3A and 2D6 enzymes. Rifampin is a strong inducer of several drug-metabolizing enzymes. The authors studied the interaction of rifampin with oxycodone. Their hypothesis was that rifampin enhances the CYP3A-mediated metabolism of oxycodone and attenuates its pharmacologic effect... CONCLUSIONS: Induction of cytochrome P450 3A by rifampin reduced the area under the oxycodone concentration-time curve of intravenous and oral oxycodone. The pharmacologic effects of oxycodone were modestly attenuated. To maintain adequate analgesia, dose adjustment of oxycodone may be necessary, when used concomitantly with rifampin.

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Clinical Trials Related to Oxycontin (Oxycodone)

Oxycodone-Naloxone Prolonged Release Tablets in Relieving Opioid-Related Constipation [Active, not recruiting]

Oxycodone-Naloxone in Relieving Opioid-Related Constipation [Active, not recruiting]
The primary objective of this study is to demonstrate that subjects with moderate to severe non-malignant pain taking oxycodone/naloxone prolonged release tablets have improvement in symptoms of constipation compared to subjects taking oxycodone prolonged release tablets alone.

Study of the Abuse Liability of Oxycodone HCl/Niacin in Subjects With a History of Opioid Abuse [Recruiting]
The purpose of this study is: (1) to assess the effect of oxycodone HCl on niacin-induced dysphoric effects when oxycodone HCl is administered in combination with niacin in subjects with a history of opioid abuse; (2) to assess the abuse liability of 4 times the usual recommended dose of Acurox (oxycodone HCl 40 mg plus niacin 240 mg) versus oxycodone HCL 40 mg alone in subjects with a history of opioid abuse.

A Study Of RN624 (PF-04383119) And Oxycodone In Patients With Pain Due To Cancer That Has Spread To Bone [Recruiting]
The purpose of this study is to investigate whether RN624 (alone and in combination with oxycodone) is safe and effective in treating pain due to cancer that has spread to bone.

OXY-1: The Pharmacogenetics of Oxycodone Analgesia in Postoperative Pain [Completed]
Patients undergoing surgery (thyroidectomy and hysterectomy) will postoperatively receive oxycodone intravenously (IV) as pain management with morphine as an escape medicine, if there is insufficient pain relief with oxycodone. Patients' pain and side effects will be registered and after 24 hours they will answer a questionnaire. All included patients will be genotyped accordingly to CYP2D6 and relevant single nucleotide polymorphisms (SNPs), and measures of plasma levels of oxycodone will be performed.

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PATIENT REVIEWS / RATINGS / COMMENTS

Oxycontin review by 61 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		post surgical pain
Dosage & duration:		10mg taken 2 times per day for the period of one week
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		Able to tolerate the pain
Side effects:		Loss of appetite, dizzy
Comments:		Following a nasal reconstruction and bone graft to my nasal bridge pain relief was prescribed. My nose was crushed in an accident. I did not think that it would be necessary, however the procedure turned out to be extremely painful for several days. The pain medication allowed me to tolerate the pain, however it made it impossible for me to function normally. All I could do was sleep and remain in a haze until the pain diminished

Oxycontin review by 56 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Extremely Severe Side Effects
		Treatment Info
Condition / reason:		pain after surgery
Dosage & duration:		10mg taken every 6 hours for the period of 1 day
Other conditions:		brusing and swelling
Other drugs taken:		Ibuprofen
		Reported Results
Benefits:		The drug was prescribed for pain, and it worked to dull post op pain.
Side effects:		The drug made me terribly constipated, which in my opinion, negated the value of the drug. The strain to eliminate was very painful considering the recent surgery.
Comments:		After 1 day of oxycontin and the ensuing constipation, I switched to 800 mg of ibuprofen. While not as effective for the pain, the constipation was alleviated. Overall, the ibuprofen was better for me.

Oxycontin review by 56 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Extremely Severe Side Effects
		Treatment Info
Condition / reason:		pain after surgery
Dosage & duration:		10mg taken every 6 hours for the period of 1 day
Other conditions:		brusing and swelling
Other drugs taken:		Ibuprofen
		Reported Results
Benefits:		The drug was prescribed for pain, and it worked to dull post op pain.
Side effects:		The drug made me terribly constipated, which in my opinion, negated the value of the drug. The strain to eliminate was very painful considering the recent surgery.
Comments:		After 1 day of oxycontin and the ensuing constipation, I switched to 800 mg of ibuprofen. While not as effective for the pain, the constipation was alleviated. Overall, the ibuprofen was better for me.