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Oxycontin (Oxycodone Hydrochloride) - Summary



OxyContin contains oxycodone which is an opioid agonist and a Schedule II controlled substance with an abuse liability similar to morphine.

OxyContin can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing OxyContin in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion.

OxyContin Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.

OxyContin Tablets are not intended for use on an as needed basis.

Patients considered opioid tolerant are those who are taking at least 60 mg oral morphine/day, 25 mcg transdermal fentanyl/hour, 30 mg oral oxycodone/day, 8 mg oral hydromorphone/day, 25 mg oral oxymorphone/day, or an equianalgesic dose of another opioid for one week or longer.

OxyContin 60 mg, 80 mg, and 160 mg Tablets, a single dose greater than 40 mg, or a total daily dose greater than 80 mg are only for use in opioid-tolerant patients, as they may cause fatal respiratory depression when administered to patients who are not tolerant to the respiratory-depressant or sedating effects of opioids.

Persons at increased risk for opioid abuse include those with a personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression). Patients should be assessed for their clinical risks for opioid abuse or addiction prior to being prescribed opioids. All patients receiving opioids should be routinely monitored for signs of misuse, abuse and addiction.

OxyContin must be swallowed whole and must not be cut, broken, chewed, crushed or dissolved. Taking cut, broken, chewed, crushed or dissolved OxyContin tablets leads to rapid release and absorption of a potentially fatal dose of oxycodone.

The concomitant use of OxyContin with all cytochrome P450 3A4 inhibitors such as macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), and protease inhibitors (e.g., ritonavir) may result in an increase in oxycodone plasma concentrations, which could increase or prolong adverse effects and may cause potentially fatal respiratory depression. Patients receiving OxyContin and a CYP3A4 inhibitor should be carefully monitored for an extended period of time and dosage adjustments should be made if warranted.



OxyContin® (oxycodone hydrochloride controlled-release) Tablets are an opioid analgesic supplied in 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg, and 160 mg tablet strengths for oral administration. The tablet strengths describe the amount of oxycodone per tablet as the hydrochloride salt.

OxyContin Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.

OxyContin is not intended for use on an as needed basis.

Physicians should individualize treatment in every case, initiating therapy at the appropriate point along a progression from non-opioid analgesics, such as non-steroidal anti-inflammatory drugs and acetaminophen to opioids in a plan of pain management such as outlined by the World Health Organization, the Agency for Healthcare Research and Quality (formerly known as the Agency for HealthCare Policy and Research), the Federation of State Medical Boards Model Guidelines, or the American Pain Society.

OxyContin is not indicated for pain in the immediate postoperative period (the first 12-24 hours following surgery), or if the pain is mild, or not expected to persist for an extended period of time. OxyContin is only indicated for postoperative use if the patient is already receiving the drug prior to surgery or if the postoperative pain is expected to be moderate to severe and persist for an extended period of time. Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate. (See American Pain Society guidelines.)

See all Oxycontin indications & dosage >>


Media Articles Related to Oxycontin (Oxycodone)

Europe Again Says HPV Vax Safe, but Petition in Spain
Source: Medscape Hematology-Oncology Headlines [2015.11.20]
Europe has again said that HPV vaccination is safe and that it is not causally linked to chronic syndromes, but some doctors remain unconvinced.
Medscape Medical News

FDA Approves Nasal Spray to Reverse Narcotic Painkiller Overdose
Source: MedicineNet Drug Abuse Specialty [2015.11.20]
Title: FDA Approves Nasal Spray to Reverse Narcotic Painkiller Overdose
Category: Health News
Created: 11/19/2015 12:00:00 AM
Last Editorial Review: 11/20/2015 12:00:00 AM

Ibandronate vs Radiotherapy for Bone Pain in Prostate Cancer
Source: Medscape Orthopaedics Headlines [2015.11.19]
Compare choices for treatment of metastatic prostate cancer related bone pain.
Journal of the National Cancer Institute

Proximal Muscle Rehabilitation for Patellofemoral Pain
Source: Medscape Orthopaedics Headlines [2015.11.19]
How do these rehabilitation protocols for patellofemoral pain compare in terms of pain reduction and improved function?
British Journal of Sports Medicine

Upsurge in Female Opioid Addiction Tied to Prescribed Pain Meds
Source: Medscape Psychiatry & Mental Health Headlines [2015.11.19]
Women are disproportionately affected by opioid addiction from prescription painkillers, new research shows.
Medscape Medical News

more news >>

Published Studies Related to Oxycontin (Oxycodone)

Comparison of subjective effects of extended-release versus immediate-release oxycodone/acetaminophen tablets in healthy nondependent recreational users of prescription opioids: a randomized trial. [2014]
[APAP]) formulation with those of immediate-release (IR) OC/APAP... CONCLUSIONS: Extended-release OC/APAP produced lower subjective drug effects than

A randomized, double-blind, placebo-controlled study of oral oxycodone plus acetaminophen for the treatment of pain in photodynamic therapy on port wine stains. [2014]
efficacy and safety of an oral analgesic for the treatment of pain in PDT on PWS... CONCLUSIONS: The time of the pain beginning was 8.31 ± 4.58 min in

Safety and efficacy of once-daily hydromorphone extended-release versus twice-daily oxycodone hydrochloride controlled-release in chinese patients with cancer pain: a phase 3, randomized, double-blind, multicenter study. [2014]
Noninferiority of the efficacy of once-daily hydromorphone hydrochloride extended-release (hydromorphone ER) compared with twice-daily oxycodone hydrochloride controlled-release (oxycodone CR) was investigated in this randomized, double-blind study in Chinese patients with moderate to severe cancer pain requiring strong oral opioid analgesics.

Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial. [2014]
control efforts efficacy and decrease the adverse effects of each medication... CONCLUSION: Intravenous acetaminophen plus oral oxycodone is as effective as

Bowel function after tapentadol and oxycodone immediate release (IR) treatment in patients with low back or osteoarthritis pain. [2013]
OBJECTIVES: Constipation is a common side effect of opioid therapy. Tapentadol immediate release (IR) was better tolerated than oxycodone IR in 2 clinical trials involving patients with low back or osteoarthritis pain... DISCUSSION: Patient-reported bowel function associated with tapentadol IR treatment was similar to that associated with placebo (10-d trial) and significantly better than that associated with oxycodone IR treatment (10- and 90-d trials).

more studies >>

Clinical Trials Related to Oxycontin (Oxycodone)

Pharmacokinetics Study of ALO-02 and OxyContin [Completed]
To characterize the single- and multiple-dose pharmacokinetics of oxycodone following the administration of ALO-02 40 Mg Twice Daily, ALO-02 80 Mg Once Daily or Oxycontin 40 Mg Twice Daily in Healthy Volunteers

Early Postoperative Administration of Oxycodone +/- Naloxone and Duration of Epidural Analgesia [Not yet recruiting]
Cystectomy with urinary diversion (ileal conduit, ileal orthotopic neobladder, catheterizable ileal pouch) is major abdominal surgery, which is associated with a high incidence of gastrointestinal complications. Perioperative techniques aiming at an early return of bowel function are to be pursued. Optimal postoperative pain management is one of the key factors leading to enhanced recovery after surgery. The perioperative use of an epidural analgesia for major abdominal surgery is established, not only because of its excellent analgesic properties, but also because it can accelerate the return of bowel function. However, epidural analgesia is associated with additional costs, need for close monitoring and nursing. In addition each supplemental day with an indwelling epidural catheter increases the risk of infection. So it is recommended to re-assess the risk/benefit ratio of an epidural analgesia after 4 days, if not sooner. Therefore, it is important to develop strategies that reduce its duration without impairing the benefits. Systemic analgesics with prolonged-release oral formulation like oral oxycodone (Oxycontin®) or combined drug mixture (oral oxycodone/naloxone (Targin®)) could be a valuable alternative pain treatment as a second analgesic step, starting on postoperative day (POD) 3, so that the epidural catheter could be removed earlier without impairing postoperative enhanced recovery including return of the bowel function. Both oxycodone and naloxone orally administered are a recognized and accepted treatment option. The objective of this study is to evaluate the implementation of an oral opioid with or without naloxone in the early postoperative period in patients undergoing open radical cystectomy with urinary diversion and intraoperative and early postoperative use of epidural analgesia. The investigators expect an unchanged early return of the bowel function and equal analgesia with a reduced length of stay of the epidural catheter (primary endpoint), thus potentially reducing epidural catheter associated complications and lowering costs (nursing and pain service).

Study of PF614 Compared to OxyContin in Healthy Volunteers [Not yet recruiting]

Pharmacokinetics And Relative Bioavailability Study Of Oxycodone [Completed]

A Study to Evaluate Efficacy and Safety of Oxycodone/Naloxone Compared to OxyContin in Korean Cancer Patients [Completed]
Objectives: To prove non-inferiority of Targin compared to Oxycontin in terms of reduction of pain intensity 1. Primary objective: Actual reduction of pain intensity (0-10) score (average pain over 24 hours obtained each evening) within 4 weeks 2. Secondary objectives: Bowel Habit (worsening/no change/improving), Total dose and frequency of rescue medication, Quality of Life (QOL; EORTC QLQ-C30), Duration to need of laxative use and Adverse events, Long term safety and efficacy

more trials >>

Reports of Suspected Oxycontin (Oxycodone) Side Effects

Drug Dependence (154)Pain (142)Drug Withdrawal Syndrome (101)Vomiting (75)Substance Abuse (68)Nausea (65)Drug Abuse (60)Death (58)Suicidal Ideation (56)Depression (53)more >>


Based on a total of 9 ratings/reviews, Oxycontin has an overall score of 6.56. The effectiveness score is 8.67 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Oxycontin review by 47 year old male patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   kidney stones
Dosage & duration:   5 to 30 mg per day taken 1 to 4 times per day for the period of 8 weeks
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   pain was relieved and could sleep with ease
Side effects:   weight loss irritability when trying to cut back. i currently take a dose of 7.5 to 10 mg per day and would like to continue same dosage
Comments:   after kidney stone i was prescribed oxycodone in a small dose of 7.5 mg for up to 6 times a day. i cut back to 2 times a day after 3 weeks and now just take about 7.5 to 10 mg per day once a day.


Oxycontin review by 34 year old male patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   pain control
Dosage & duration:   10 mg taken 2-3 times a day depending on pain for the period of 3 weeks
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   The treatment benefits were considerable as OxyContin reduced my pain considerably. In the beginning I was advized to take the drug 1 hour before the previous one wore off as it can take up to 1 hour for it to work. The pain however always did go away and therefore relieving me of it and making me feel comfortable again.
Side effects:   After using the drug for a while I was becoming more and more dependant on it. Therefore I was becomming addicted to this drug as I was depending on it to relieve my pain. I also noticed that while taking this drug I was becoming constipated where in the past that has never been an issue for me.
Comments:   This medication was prescribed to me following my knee arthroplasty. I had a surgery done on my knee where the joints have been replaced. following the surgery I had severe pain and so the doctor as opposed to morphine prescribed OxyContin. I was taking this drug 3 times a day and later 2 to 3 times depending on my pain. The drug worked very well and I was satisfied with it.


Oxycontin review by 56 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Extremely Severe Side Effects
Treatment Info
Condition / reason:   pain after surgery
Dosage & duration:   10mg taken every 6 hours for the period of 1 day
Other conditions:   brusing and swelling
Other drugs taken:   Ibuprofen
Reported Results
Benefits:   The drug was prescribed for pain, and it worked to dull post op pain.
Side effects:   The drug made me terribly constipated, which in my opinion, negated the value of the drug. The strain to eliminate was very painful considering the recent surgery.
Comments:   After 1 day of oxycontin and the ensuing constipation, I switched to 800 mg of ibuprofen. While not as effective for the pain, the constipation was alleviated. Overall, the ibuprofen was better for me.

See all Oxycontin reviews / ratings >>

Page last updated: 2015-11-20

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