WARNING:
OxyContin is an opioid agonist and a Schedule II controlled substance with an abuse liability similar to morphine.
Oxycodone can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing OxyContin in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion.
OxyContin Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous, around-the-clock analgesic is needed for an extended period of time.
OxyContin Tablets are NOT intended for use as a prn analgesic.
OxyContin 80 mg and 160 mg Tablets ARE FOR USE IN OPIOID-TOLERANT PATIENTS ONLY. These tablet strengths may cause fatal respiratory depression when administered to patients not previously exposed to opioids.
OxyContin TABLETS ARE TO BE SWALLOWED WHOLE AND ARE NOT TO BE BROKEN, CHEWED, OR CRUSHED. TAKING BROKEN, CHEWED, OR CRUSHED OxyContin TABLETS LEADS TO RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE OF OXYCODONE.
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OXYCONTIN SUMMARY
OXYCONTIN®
(OXYCODONE HCL CONTROLLED-RELEASE) TABLETS CII
10 mg 20 mg 40 mg 80 mg* 160 mg*
OxyContin® (oxycodone hydrochloride controlled-release) Tablets are an opioid analgesic supplied in 10 mg, 20 mg, 40 mg, 80 mg, and 160 mg tablet strengths for oral administration. The tablet strengths describe the amount of oxycodone per tablet as the hydrochloride salt.
OxyContin Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous, around-the-clock analgesic is needed for an extended period of time.
OxyContin is NOT intended for use as a prn analgesic.
Physicians should individualize treatment in every case, initiating therapy at the appropriate point along a progression from non-opioid analgesics, such as non-steroidal anti-inflammatory drugs and acetaminophen to opioids in a plan of pain management such as outlined by the World Health Organization, the Agency for Healthcare Research and Quality (formerly known as the Agency for Health Care Policy and Research), the Federation of State Medical Boards Model Guidelines, or the American Pain Society.
OxyContin is not indicated for pain in the immediate postoperative period (the first 12-24 hours following surgery), or if the pain is mild, or not expected to persist for an extended period of time. OxyContin is only indicated for postoperative use if the patient is already receiving the drug prior to surgery or if the postoperative pain is expected to be moderate to severe and persist for an extended period of time. Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate. (See American Pain Society guidelines.)
OxyContin® is a mu-agonist opioid with an abuse liability similar to morphine and is a Schedule II controlled substance. Oxycodone, like morphine and other opioids used in analgesia, can be abused and is subject to criminal diversion.
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OXYCONTIN NEWS HIGHLIGHTS Media Articles Related to Oxycontin (Oxycodone)
'Abuse-Resistant' Form of OxyContin May Be Near
Source: MedicineNet oxycodone Specialty [2008.09.12]
Title: 'Abuse-Resistant' Form of OxyContin May Be Near
Category: Health News
Created: 9/12/2008 2:00:00 AM
Last Editorial Review: 9/12/2008
Teen Brain Might Get Hooked Easier on OxyContin
Source: MedicineNet oxycodone and acetaminophen Specialty [2008.09.11]
Title: Teen Brain Might Get Hooked Easier on OxyContin
Category: Health News
Created: 9/11/2008 2:00:00 AM
Last Editorial Review: 9/11/2008
Oxycodone May Reduce Shingles Pain
Source: MedicineNet Chickenpox (Varicella) Specialty [2009.04.13]
Title: Oxycodone May Reduce Shingles Pain
Category: Health News
Created: 4/11/2009 2:00:00 AM
Last Editorial Review: 4/13/2009
New Treatment For Receding Gums: No Pain, Lots Of Gain
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2009.07.02]
Tufts dental researchers conducted a three-year follow-up study that examined the stability of a treatment option for receding gums and found that complete root coverage the goal of the surgery had been maintained. This specific tissue regeneration application, developed at Tufts, reduces the considerable pain and recovery time of gum grafting surgery. The case study of six patients is published in the July 2009 issue of the Journal of Periodontology.
Increasing Age Of Mothers In Spain Leads To Rise In Mortality Rates
Source: Seniors / Aging News From Medical News Today [2009.07.02]
A new study examining the evolution of maternal mortality rates in Spain since 1996 shows a 17% increase in deaths. This trend is linked to the widespread increase in maternal age. The highest death rates are among foreign women and those who live in the province of Malaga. Medicine has taken giant strides during the 20th Century. However, European studies show a clear and constant increase in maternal mortality rates over recent years.
Published Studies Related to Oxycontin (Oxycodone)
A randomized, placebo-controlled trial of oxycodone and of gabapentin for acute pain in herpes zoster. [2009.02.03]
Although acute pain in patients with herpes zoster can be severe and has a substantial impact on health-related quality of life, there have been no randomized clinical trials of oral medications specifically for its ongoing treatment. A randomized clinical trial was conducted in which 87 subjects 50 years of age with herpes zoster within 6 calendar days of rash onset and with worst pain in the past 24h3 on a 0-10 rating scale initiated 7 days of treatment with famciclovir in combination with 28 days of treatment with either controlled-release (CR) oxycodone [generic for Oxycontin], gabapentin, or placebo...
Analgesic efficacy and safety of oxycodone in combination with naloxone as prolonged release tablets in patients with moderate to severe chronic pain. [2008.12]
This randomized, double-blind, placebo- and active-controlled, parallel-group study was designed to demonstrate the superiority of oxycodone [generic for Oxycontin] in combination with naloxone in a prolonged release (PR) formulation over placebo with respect to analgesic efficacy. The active control group was included for sensitivity and safety analyses, and furthermore to compare the analgesic efficacy and bowel function of oxycodone PR/naloxone PR with oxycodone PR alone.
Oxycodone versus codeine for triage pain in children with suspected forearm fracture: a randomized controlled trial. [2008.09]
OBJECTIVE: To compare the efficacy of pain reduction of triage oxycodone [generic for Oxycontin] (O) versus codeine (C) to children with suspected forearm fractures... CONCLUSIONS: Triage-administered O tended toward greater pain reduction compared with C in children with suspected forearm fractures. Although minor adverse effects occurred in both groups, itching occurred more in C. Identification of radiography as the most painful part of fracture evaluation underscores the need for early triage administration of analgesia for suspected fractures.
Pharmacokinetic-pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model. [2008.05]
Analgesia from most opioids is mediated by mu receptors located mainly in the central nervous system. Previous studies have shown a different pharmacological profile of oxycodone [generic for Oxycontin] in respect to visceral analgesia... Oxycodone and morphine showed different pharmacodynamic/pharmacokinetic relationships for the visceral analgesia, whereas relationships were alike for somatic analgesia.
The effect of single-dose tramadol on oxycodone clearance. [2007.11]
We have noticed increased prescribing of tramadol by emergency physicians for breakthrough pain in patients chronically taking oxycodone [generic for Oxycontin]. Both oxycodone and tramadol undergo oxidative metabolism by CYP2D6 and CYP3A4, suggesting the possibility that tramadol may compete with oxycodone for metabolism...
Clinical Trials Related to Oxycontin (Oxycodone)
Oxycodone-Naloxone Prolonged Release Tablets in Relieving Opioid-Related Constipation [Active, not recruiting]
Oxycodone-Naloxone in Relieving Opioid-Related Constipation [Active, not recruiting]
The primary objective of this study is to demonstrate that subjects with moderate to severe
non-malignant pain taking oxycodone/naloxone prolonged release tablets have improvement in
symptoms of constipation compared to subjects taking oxycodone prolonged release tablets
alone.
Study of the Abuse Liability of Oxycodone HCl/Niacin in Subjects With a History of Opioid Abuse [Recruiting]
The purpose of this study is: (1) to assess the effect of oxycodone HCl on niacin-induced
dysphoric effects when oxycodone HCl is administered in combination with niacin in subjects
with a history of opioid abuse; (2) to assess the abuse liability of 4 times the usual
recommended dose of Acurox (oxycodone HCl 40 mg plus niacin 240 mg) versus oxycodone HCL 40
mg alone in subjects with a history of opioid abuse.
A Study Of RN624 (PF-04383119) And Oxycodone In Patients With Pain Due To Cancer That Has Spread To Bone [Recruiting]
The purpose of this study is to investigate whether RN624 (alone and in combination with
oxycodone) is safe and effective in treating pain due to cancer that has spread to bone.
OXY-1: The Pharmacogenetics of Oxycodone Analgesia in Postoperative Pain [Completed]
Patients undergoing surgery (thyroidectomy and hysterectomy) will postoperatively receive
oxycodone intravenously (IV) as pain management with morphine as an escape medicine, if there
is insufficient pain relief with oxycodone. Patients' pain and side effects will be
registered and after 24 hours they will answer a questionnaire. All included patients will be
genotyped accordingly to CYP2D6 and relevant single nucleotide polymorphisms (SNPs), and
measures of plasma levels of oxycodone will be performed.
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OXYCONTIN PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Oxycontin has an overall score of 4. The effectiveness score is 6 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
| | Oxycontin review by 28 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | post-surgical pain |
| Dosage & duration: | | 5-10 mg taken approx every 6-8 hrs for the period of 5 days |
| Other conditions: | | bowels slow to function after surgery |
| Other drugs taken: | | stool softener, ibuprofin, acetaminophen | | |
Reported Results |
| Benefits: | | The pain was definitely reduced, from high discomfort to relatively low discomfort, so long as I wasn't moving. It also helped me to sleep some of the time. |
| Side effects: | | During the second and third day, it seemed to increase my post-surgical nausea. Overall, in addition to drowsiness, I experienced a lot of dizziness. I'm not sure whether or not it affected my bowels returning to normal function. |
| Comments: | | At first I was given the oxycodone intravenously, with a button allowing me to choose when I wanted a dose (don't remember the amount) but limited in total amount and frequency (up to every 15 minutes, I think.) Afterwards, I took it in pill form. After several days I decided the side effects were too strong and got a hydrocodone prescription, which had similar but more mild side effects. In retrospect, I wish that acupunture had been available; when I experienced an auricular 5-needle protocol several weeks later, I found the residual pain I had was immediately reduced, with none of the side effects. |
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Page last updated: 2009-07-02
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