Media Articles Related to Oxycodone and Aspirin (Oxycodone / Oxycodone / Aspirin)
New Bill to Put 7-Day Limit on Pain Med Prescriptions
Source: Medscape Anesthesiology Headlines [2017.04.19]
Following similar action by several states, two US senators have introduced bipartisan legislation that would limit initial opioid prescription for acute pain to 7 days.
Medscape Medical News
Structural Pathology Not Related to Knee Pain and Function
Source: Medscape Anesthesiology Headlines [2017.04.19]
A new study found that structural knee pathologies were not associated with patient-reported symptoms among those undergoing arthroscopic meniscal surgery.
British Journal of Sports Medicine
Study paints somber picture of US mental health status and access to care
Source: Psychology / Psychiatry News From Medical News Today [2017.04.19]
More Americans than ever before suffer from serious psychological distress, and the country's ability to meet the growing demand for mental health services is rapidly eroding.
CardioBrief: Single Blood Test May Rapidly Rule Out MI in Chest Pain for Some Patients
Source: MedPage Today Emergency Medicine [2017.04.17]
(MedPage Today) -- New high-sensitivity troponin tests may ease perpetual ED dilemma
Spinal manipulation treatment for low back pain associated with modest improvement in pain, function
Source: Bones / Orthopedics News From Medical News Today [2017.04.14]
Among patients with acute low back pain, spinal manipulation therapy was associated with modest improvements in pain and function at up to 6 weeks, with temporary minor musculoskeletal harms...
Published Studies Related to Oxycodone and Aspirin (Oxycodone / Oxycodone / Aspirin)
Oxycodone-related side effects: impact on degree of bother, adherence, pain relief, satisfaction, and quality of life. [2011.05]
OBJECTIVES: Oxycodone immediate-release, alone or in combination (hereafter, oxycodone), is widely used to treat pain and is often associated with bothersome side effects. The objective was to assess side effect frequency, degree of bother, and impact on health-related quality of life (HRQoL)... CONCLUSIONS: The majority of survey respondents experienced side effects of oxycodone, with a majority being bothered by side effects and impacting their QoL. This raises a question about the unmet need for pain medications with improved side effect profiles.
Oxycodone combinations for pain relief. [2010.06]
No single analgesic drug provides the perfect therapeutic/adverse effect profile for every pain condition. In addition to convenience and possibly improved compliance, a combination of analgesic drugs offers the potential, requiring verification, of providing greater pain relief and/or reduced adverse effects than the constituent drugs when used individually...
Clinical Trials Related to Oxycodone and Aspirin (Oxycodone / Oxycodone / Aspirin)
Early Postoperative Administration of Oxycodone +/- Naloxone and Duration of Epidural Analgesia [Not yet recruiting]
Cystectomy with urinary diversion (ileal conduit, ileal orthotopic neobladder,
catheterizable ileal pouch) is major abdominal surgery, which is associated with a high
incidence of gastrointestinal complications. Perioperative techniques aiming at an early
return of bowel function are to be pursued.
Optimal postoperative pain management is one of the key factors leading to enhanced recovery
after surgery. The perioperative use of an epidural analgesia for major abdominal surgery is
established, not only because of its excellent analgesic properties, but also because it can
accelerate the return of bowel function. However, epidural analgesia is associated with
additional costs, need for close monitoring and nursing. In addition each supplemental day
with an indwelling epidural catheter increases the risk of infection. So it is recommended
to re-assess the risk/benefit ratio of an epidural analgesia after 4 days, if not sooner.
Therefore, it is important to develop strategies that reduce its duration without impairing
the benefits. Systemic analgesics with prolonged-release oral formulation like oral
oxycodone (OxycontinÂ®) or combined drug mixture (oral oxycodone/naloxone (TarginÂ®)) could be
a valuable alternative pain treatment as a second analgesic step, starting on postoperative
day (POD) 3, so that the epidural catheter could be removed earlier without impairing
postoperative enhanced recovery including return of the bowel function. Both oxycodone and
naloxone orally administered are a recognized and accepted treatment option.
The objective of this study is to evaluate the implementation of an oral opioid with or
without naloxone in the early postoperative period in patients undergoing open radical
cystectomy with urinary diversion and intraoperative and early postoperative use of epidural
analgesia. The investigators expect an unchanged early return of the bowel function and
equal analgesia with a reduced length of stay of the epidural catheter (primary endpoint),
thus potentially reducing epidural catheter associated complications and lowering costs
(nursing and pain service).
Pharmacokinetics And Relative Bioavailability Study Of Oxycodone [Completed]
Abuse Liability of Controlled-Release Oxycodone Formulations [Completed]
The objective of this study is to examine the abuse liability of a single 40mg dose of 2
controlled release oxycodone formulations (Apo-Oxycodone CR® and OxyNEO®) in non-dependent
recreational opioid users by assessing the self-reported acute effects of the drugs and
taking blood samples to measure drug concentrations. The investigators think there may be
differences in how well these drugs are liked when swallowed whole due to differences in how
the products are formulated.
Comparison of the Efficacy of Oral Oxycodone and Oral Codeine in the Treatment of Postcraniotomy Pain [Completed]
The efficacy of codeine is dependent on its demethylation to morphine. This extent of
demethylation has wide inter-individual variability, making codeine's efficacy as a
analgesic variable. Oxycodone is a semi-synthetic opioid and is a weak agonist on mu opioid
Codeine has been the mainstay of analgesia for patients after craniotomy for many years.
Traditionally, craniotomies were not thought to be very painful procedures, hence the use of
codeine, a moderately potent opioid (when compared to morphine).
However, in recent years, it has been found that up to 70% of post-craniotomy patients have
moderate to severe pain and codeine did not provide adequate analgesic relief. Many studies
have compared codeine to other drugs such as PCA morphine, fentanyl and tramadol, and
patients on these stronger opioids generally had lower pain scores and better satisfaction.
No study has been conducted to determine the efficacy of analgesia of oral oxycodone to oral
Hence, the hypothesis is that oxycodone is more effective than codeine in providing pain
relief in post-craniotomy patients.
Comparison of the Effects of Tapentadol and Oxycodone on Gastrointestinal and Colonic Transit in Humans [Completed]
Tapentadol is FDA approved for the treatment of moderate to severe acute pain. Due to the
dual mechanism of action as an opioid agonist and norepinephrine reuptake inhibitor, there
is potential for off label use in chronic pain.
Tapentadol is a new molecular entity that is structurally similar to tramadol. Tapentadol
is a centrally-acting analgesic with a dual mode of action as an agonist at the mu-opioid
receptor and as a norepinephrine reuptake inhibitor. These two actions are synergistic in
pain relief. While its action reflects aspects of tramadol and morphine, its ability to
control pain is more on the order of hydrocodone and oxycodone.
Its dual mode of action provides analgesia at similar levels of more potent narcotic
analgesics such as hydrocodone, oxycodone, and meperidine with a more tolerable side effect
profile. Clinical studies showed that tapentadol effectively relieves moderate to severe
pain in various pain care settings. In addition, it was reported to be associated with
significantly fewer treatment discontinuations due to a significantly lower incidence of
gastrointestinal-related adverse events compared with equivalent doses of oxycodone. The
combination of these reduced treatment discontinuation rates and tapentadol efficacy for the
relief of moderate to severe nociceptive and neuropathic pain may offer an improvement in
pain therapy by increasing patient compliance with their treatment regimen.