OXYCODONE AND ACETAMINOPHEN CAPSULES USP
Each capsule, for oral administration, contains:
Oxycodone hydrochloride USP 5 mg (equivalent to 4.4815 mg of oxycodone)
Acetaminophen USP 500 mg
The oxycodone component is 14-hydroxydihydrocodeinone, an opiate analgesic.
Acetaminophen, 4’-hydroxyacetanilide, is a non-opiate, non-salicylate analgesic and antipyretic.
Oxycodone and acetaminophen capsules are indicated for the relief of moderate to moderately severe pain.
Published Studies Related to Oxycodone and Acetaminophen (Oxycodone / Acetaminophen)
Dexamethasone decreases oxycodone consumption following osteotomy of the first metatarsal bone: a randomized controlled trial in day surgery. [2010.03]
BACKGROUND: Dexamethasone may improve multimodal pain management following painful orthopedic day surgery procedures, and decrease the need for post-operative opioids. We hypothesized that dexamethasone would reduce the need for oxycodone after surgical correction of hallux valgus... CONCLUSION: Oral dexamethasone combined with paracetamol significantly reduced total oxycodone consumption following surgical correction of hallux valgus.
Oxycodone/acetaminophen at low dosage: an alternative pain treatment for patients with rheumatoid arthritis. [2010.01]
OBJECTIVES: To assess efficacy and safety of the association oxycodone/acetaminophen (oxycodone/acetaminophen) for pain treatment and disability improvement in patients with rheumatoid arthritis (RA)... CONCLUSION: Oxycodone/acetaminophen at low dosages for the treatment of chronic pain in RA patients can be a good alternative to non-steroidal antiinflammatory drugs (NSAIDs), allowing the reduction of their consumption, while keeping RA therapy stable.
Within-subject comparison of the psychopharmacological profiles of oral hydrocodone and oxycodone combination products in non-drug-abusing volunteers. [2009.04.01]
BACKGROUND: Non-medical use and abuse of prescription opioids is a significant problem in the United States. Little attention has been paid to assessing the relative psychopharmacological profile (including abuse liability-related effects) of specific prescription opioids. The purpose of this study was to directly compare the psychopharmacological profile of two widely prescribed and abused oral opioid combination products within the same subject... CONCLUSIONS: Consistent with a recent study published in this journal using identical doses of HYD and OXY (without ACET) in prescription opioid abusers (Walsh, S.L., Nuzzo, P.A., Lofwall, M.R., Holtman Jr., J.R., 2008. The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription drug abusers. Drug Alcohol Depend. 198, 191-202), we found little difference in the pharmacodynamic effects of HYD/ACET and OXY/ACET in non-drug-abusing volunteers.
Effect of delayed activated charcoal on acetaminophen concentration after simulated overdose of oxycodone and acetaminophen. [2009.02]
OBJECTIVE: To determine the effect of activated charcoal (AC) on acetaminophen (APAP) absorption kinetics when administered at 1, 2, or 3 h after combined oral overdose with oxycodone... CONCLUSION: The effect of AC rapidly declines between 1 and 3 h after combined oral overdose of APAP and oxycodone. AC is unlikely to be beneficial at or beyond 2 h after an overdose of acetaminophen and oxycodone.
Clinical equivalence of controlled-release oxycodone 20 mg and controlled-release tramadol 200 mg after surgery for breast cancer. 
AIMS: To assess clinical equivalence of 20 mg controlled-release oxycodone (Oxygesic; Mundipharma, Limburg, Germany) and 200 mg controlled-release tramadol (Tramal long; Grunenthal, Aachen, Germany) on a 12-hour dosing schedule in a randomized, double-blinded study of 54 ASA I-III physical status (American Society of Anesthesiologists classification of physical status) patients undergoing surgery for breast cancer... CONCLUSION: 20 mg controlled-release oxycodone is clinically equivalent to 200 mg controlled-release tramadol for postoperative analgesia after surgery for breast cancer. Copyright 2009 S. Karger AG, Basel.
Clinical Trials Related to Oxycodone and Acetaminophen (Oxycodone / Acetaminophen)
Oxycodone-Naloxone in Relieving Opioid-Related Constipation [Active, not recruiting]
The primary objective of this study is to demonstrate that subjects with moderate to severe
non-malignant pain taking oxycodone/naloxone prolonged release tablets have improvement in
symptoms of constipation compared to subjects taking oxycodone prolonged release tablets
Oxycodone-Naloxone Prolonged Release Tablets in Relieving Opioid-Related Constipation [Active, not recruiting]
Oxycodone for Labor Pain - Pharmacokinetics (PK), Safety and Efficacy [Not yet recruiting]
Childbirth is one of the most painful events that a woman is likely to experience, and thus
is a major concern for most parturient. Severe pain releases stress mediators and may thus
compromise fetus well-being if placental perfusion is decreased. Epidural analgesia is the
golden standard for the management of severe labor pain. However, it could not always be
used both due the parturient related factors and the organizational reasons. However, the
knowledge on safety and efficacy of oxycodone involving mother, fetus and newborn is
Aim of the study is firstly, to evaluate the efficacy and safety of oxycodone in labor pain
healthy parturients. Secondly, to measure parturient's blood oxycodone concentration during
labour and fetal concentration from placental umbilical vein and artery right after birth.
Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery [Recruiting]
The main hypothesis of this study is that preoperative administration of controlled-release
(CR) oxycodone may reduce acute postoperative pain and improve time to discharge from the
post-anesthesia care unit in patients undergoing video-assisted thoracoscopy for spontaneous
The study drug will be compared with intravenous morphine administered 30 minutes before the
end of anesthesia.
Efficacy of Oxycodone/Naloxone, Compared to Oxycodone, for the Reduction of Intensity of Opioid-induced Constipation in Pain Patients [Recruiting]
Reports of Suspected Oxycodone and Acetaminophen (Oxycodone / Acetaminophen) Side Effects
Drug Ineffective (24),
Toxicity TO Various Agents (8),
Multiple Drug Overdose (7),
Drug Administration Error (6),
Product Quality Issue (4),
Withdrawal Syndrome (4),
Confusional State (3),
Pain (3), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 1 ratings/reviews, Oxycodone and Acetaminophen has an overall score of 7. The effectiveness score is 6 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
Oxycodone and Acetaminophen review by 49 year old male patient
|Overall rating:|| || |
|Effectiveness:|| || Moderately Effective|
|Side effects:|| || Moderate Side Effects|
|Condition / reason:|| || NECK AND BACK PAIN|
|Dosage & duration:|| || 5 / 325 TAB MCK - FOUR TIMES PER DAY. taken 4 tablets per day- every six hours for the period of FOR 2 & 1/2 MONTHS AND STILL TAKING IT.|
|Other conditions:|| || NONE|
|Other drugs taken:|| || NAPROXEN SODIUM|
|Benefits:|| || IT WORKED FOR RELIEVING SOME OF MY NECK AND BACK PAIN. PLEASE NOTE, MY CAUSE OF PAIN WAS DUE TO SURGERY PAIN AND NOT YOUR NORMAL KIND OF BACK PAIN. I MUST SAY THAT IT JUST KIND OF TOOK THE EDGE OFF OF THE SEVERE PAIN I WAS FEELING.
AS TIME WENT ON I BEGAN TO HEAL AND FEEL MUCH BETTER AND NOW IT TENDS TO WORK MUCH BETTER.|
|Side effects:|| || SOMETIMES TROUBLE BREATHING AND TROUBLE URINATING. ALSO, FELT DROWSY DURING THE DAY. THE BREATHING AND THE URINATING PROBLEMS STOPPED AFTER ABOUT A WEEK ON THIS MEDICATION. AS FOR THE DROWSY FEELING, I STILL EXPERIENCE THAT AND TRY NOT TO DRIVE WHILE ON THIS MEDICATION. I EXPERIENCE NO OTHER SIDE EFFECT EVEN THOUGH I AM STILL TAKING THE MEDICATION. |
|Comments:|| || DUE TO A SLIP AND FALL ACCIDENT, I NEEDED TO GET BACK SURGERY FOR MY CONDITION.
THE TYPE OF SURGERY I HAD WAS CALLED ANTERIOR CERVICAL DISKECTOMY AND FUSION FOR CERVICAL DISC DISPLACEMENT. THE DOCTOR PRESCRIBED OXYCODONE ALONG WITH NAPROXEN. I RARELY TOOK THE NAPROXEN BUT TOOK THE OXYCODONE FOUR TIMES A DAY FOR TWO MONTHS. AT THIS TIME, I STILL TAKE THE MEDICATION ONLY WHEN I FEEL I NEED IT - APPROXIMATELY ONCE OR TWICE A DAY.
Page last updated: 2010-10-05