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Oxycodone and Acetaminophen (Oxycodone / Acetaminophen) - Summary

 
 



SUMMARY

OXYCODONE AND ACETAMINOPHEN CAPSULES USP

Each capsule, for oral administration, contains:

Oxycodone hydrochloride USP 5 mg (equivalent to 4.4815 mg of oxycodone)

Acetaminophen USP 500 mg

The oxycodone component is 14-hydroxydihydrocodeinone, an opiate analgesic.

Acetaminophen, 4-hydroxyacetanilide, is a non-opiate, non-salicylate analgesic and antipyretic.

Oxycodone and acetaminophen capsules are indicated for the relief of moderate to moderately severe pain.


See all Oxycodone and Acetaminophen indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Oxycodone and Acetaminophen (Oxycodone / Acetaminophen)

Comparison of subjective effects of extended-release versus immediate-release oxycodone/acetaminophen tablets in healthy nondependent recreational users of prescription opioids: a randomized trial. [2014]
[APAP]) formulation with those of immediate-release (IR) OC/APAP... CONCLUSIONS: Extended-release OC/APAP produced lower subjective drug effects than

A randomized, double-blind, placebo-controlled study of oral oxycodone plus acetaminophen for the treatment of pain in photodynamic therapy on port wine stains. [2014]
efficacy and safety of an oral analgesic for the treatment of pain in PDT on PWS... CONCLUSIONS: The time of the pain beginning was 8.31 ± 4.58 min in

Comparison of the efficacy and safety of dual-opioid treatment with morphine plus oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after total knee arthroplasty. [2013]
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose

Dexamethasone decreases oxycodone consumption following osteotomy of the first metatarsal bone: a randomized controlled trial in day surgery. [2010.03]
BACKGROUND: Dexamethasone may improve multimodal pain management following painful orthopedic day surgery procedures, and decrease the need for post-operative opioids. We hypothesized that dexamethasone would reduce the need for oxycodone after surgical correction of hallux valgus... CONCLUSION: Oral dexamethasone combined with paracetamol significantly reduced total oxycodone consumption following surgical correction of hallux valgus.

Oxycodone/acetaminophen at low dosage: an alternative pain treatment for patients with rheumatoid arthritis. [2010.01]
OBJECTIVES: To assess efficacy and safety of the association oxycodone/acetaminophen (oxycodone/acetaminophen) for pain treatment and disability improvement in patients with rheumatoid arthritis (RA)... CONCLUSION: Oxycodone/acetaminophen at low dosages for the treatment of chronic pain in RA patients can be a good alternative to non-steroidal antiinflammatory drugs (NSAIDs), allowing the reduction of their consumption, while keeping RA therapy stable.

more studies >>

Clinical Trials Related to Oxycodone and Acetaminophen (Oxycodone / Acetaminophen)

Oxycodone-Naloxone in Relieving Opioid-Related Constipation [Active, not recruiting]
The primary objective of this study is to demonstrate that subjects with moderate to severe non-malignant pain taking oxycodone/naloxone prolonged release tablets have improvement in symptoms of constipation compared to subjects taking oxycodone prolonged release tablets alone.

Oxycodone-Naloxone Prolonged Release Tablets in Relieving Opioid-Related Constipation [Active, not recruiting]

Oxycodone for Labor Pain - Pharmacokinetics (PK), Safety and Efficacy [Not yet recruiting]
Childbirth is one of the most painful events that a woman is likely to experience, and thus is a major concern for most parturient. Severe pain releases stress mediators and may thus compromise fetus well-being if placental perfusion is decreased. Epidural analgesia is the golden standard for the management of severe labor pain. However, it could not always be used both due the parturient related factors and the organizational reasons. However, the knowledge on safety and efficacy of oxycodone involving mother, fetus and newborn is limited.

Aim of the study is firstly, to evaluate the efficacy and safety of oxycodone in labor pain healthy parturients. Secondly, to measure parturient's blood oxycodone concentration during labour and fetal concentration from placental umbilical vein and artery right after birth.

Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery [Recruiting]
The main hypothesis of this study is that preoperative administration of controlled-release (CR) oxycodone may reduce acute postoperative pain and improve time to discharge from the post-anesthesia care unit in patients undergoing video-assisted thoracoscopy for spontaneous pneumothorax.

The study drug will be compared with intravenous morphine administered 30 minutes before the end of anesthesia.

Efficacy of Oxycodone/Naloxone, Compared to Oxycodone, for the Reduction of Intensity of Opioid-induced Constipation in Pain Patients [Recruiting]

more trials >>

Reports of Suspected Oxycodone and Acetaminophen (Oxycodone / Acetaminophen) Side Effects

Drug Ineffective (24)Toxicity TO Various Agents (8)Multiple Drug Overdose (7)Drug Administration Error (6)Overdose (5)Hypotension (5)Product Quality Issue (4)Withdrawal Syndrome (4)Confusional State (3)Pain (3)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Oxycodone and Acetaminophen has an overall score of 7. The effectiveness score is 6 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
 

Oxycodone and Acetaminophen review by 49 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   NECK AND BACK PAIN
Dosage & duration:   5 / 325 TAB MCK - FOUR TIMES PER DAY. taken 4 tablets per day- every six hours for the period of FOR 2 & 1/2 MONTHS AND STILL TAKING IT.
Other conditions:   NONE
Other drugs taken:   NAPROXEN SODIUM
  
Reported Results
Benefits:   IT WORKED FOR RELIEVING SOME OF MY NECK AND BACK PAIN. PLEASE NOTE, MY CAUSE OF PAIN WAS DUE TO SURGERY PAIN AND NOT YOUR NORMAL KIND OF BACK PAIN. I MUST SAY THAT IT JUST KIND OF TOOK THE EDGE OFF OF THE SEVERE PAIN I WAS FEELING. AS TIME WENT ON I BEGAN TO HEAL AND FEEL MUCH BETTER AND NOW IT TENDS TO WORK MUCH BETTER.
Side effects:   SOMETIMES TROUBLE BREATHING AND TROUBLE URINATING. ALSO, FELT DROWSY DURING THE DAY. THE BREATHING AND THE URINATING PROBLEMS STOPPED AFTER ABOUT A WEEK ON THIS MEDICATION. AS FOR THE DROWSY FEELING, I STILL EXPERIENCE THAT AND TRY NOT TO DRIVE WHILE ON THIS MEDICATION. I EXPERIENCE NO OTHER SIDE EFFECT EVEN THOUGH I AM STILL TAKING THE MEDICATION.
Comments:   DUE TO A SLIP AND FALL ACCIDENT, I NEEDED TO GET BACK SURGERY FOR MY CONDITION. THE TYPE OF SURGERY I HAD WAS CALLED ANTERIOR CERVICAL DISKECTOMY AND FUSION FOR CERVICAL DISC DISPLACEMENT. THE DOCTOR PRESCRIBED OXYCODONE ALONG WITH NAPROXEN. I RARELY TOOK THE NAPROXEN BUT TOOK THE OXYCODONE FOUR TIMES A DAY FOR TWO MONTHS. AT THIS TIME, I STILL TAKE THE MEDICATION ONLY WHEN I FEEL I NEED IT - APPROXIMATELY ONCE OR TWICE A DAY.

See all Oxycodone and Acetaminophen reviews / ratings >>

Page last updated: 2014-11-30

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