SUMMARY
Each tablet, for oral administration, contains oxycodone hydrochloride and acetaminophen.
Oxycodone, 4,5α-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one hydrochloride, is a semisynthetic opioid analgesic.
Acetaminophen, 4'-hydroxyacetanilide, is a non-opiate, non-salicylate analgesic and antipyretic.
Oxycodone and acetaminophen tablets USP are indicated for the relief of moderate to moderately severe pain.
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NEWS HIGHLIGHTS
Published Studies Related to Oxycodone and Acetaminophen (Oxycodone / Acetaminophen)
Comparison of subjective effects of extended-release versus immediate-release
oxycodone/acetaminophen tablets in healthy nondependent recreational users of
prescription opioids: a randomized trial. [2014] [APAP]) formulation with those of immediate-release (IR) OC/APAP... CONCLUSIONS: Extended-release OC/APAP produced lower subjective drug effects than
A randomized, double-blind, placebo-controlled study of oral oxycodone plus
acetaminophen for the treatment of pain in photodynamic therapy on port wine
stains. [2014] efficacy and safety of an oral analgesic for the treatment of pain in PDT on PWS... CONCLUSIONS: The time of the pain beginning was 8.31 ± 4.58 min in
Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate
in acute bone fracture pain control: a double-blind placebo-controlled randomized
clinical trial. [2014] control efforts efficacy and decrease the adverse effects of each medication... CONCLUSION: Intravenous acetaminophen plus oral oxycodone is as effective as
Comparison of the efficacy and safety of dual-opioid treatment with morphine plus
oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after
total knee arthroplasty. [2013] oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose
Dexamethasone decreases oxycodone consumption following osteotomy of the first metatarsal bone: a randomized controlled trial in day surgery. [2010.03] BACKGROUND: Dexamethasone may improve multimodal pain management following painful orthopedic day surgery procedures, and decrease the need for post-operative opioids. We hypothesized that dexamethasone would reduce the need for oxycodone after surgical correction of hallux valgus... CONCLUSION: Oral dexamethasone combined with paracetamol significantly reduced total oxycodone consumption following surgical correction of hallux valgus.
Clinical Trials Related to Oxycodone and Acetaminophen (Oxycodone / Acetaminophen)
Early Postoperative Administration of Oxycodone +/- Naloxone and Duration of Epidural Analgesia [Not yet recruiting]
Cystectomy with urinary diversion (ileal conduit, ileal orthotopic neobladder,
catheterizable ileal pouch) is major abdominal surgery, which is associated with a high
incidence of gastrointestinal complications. Perioperative techniques aiming at an early
return of bowel function are to be pursued.
Optimal postoperative pain management is one of the key factors leading to enhanced recovery
after surgery. The perioperative use of an epidural analgesia for major abdominal surgery is
established, not only because of its excellent analgesic properties, but also because it can
accelerate the return of bowel function. However, epidural analgesia is associated with
additional costs, need for close monitoring and nursing. In addition each supplemental day
with an indwelling epidural catheter increases the risk of infection. So it is recommended
to re-assess the risk/benefit ratio of an epidural analgesia after 4 days, if not sooner.
Therefore, it is important to develop strategies that reduce its duration without impairing
the benefits. Systemic analgesics with prolonged-release oral formulation like oral
oxycodone (Oxycontin®) or combined drug mixture (oral oxycodone/naloxone (Targin®)) could be
a valuable alternative pain treatment as a second analgesic step, starting on postoperative
day (POD) 3, so that the epidural catheter could be removed earlier without impairing
postoperative enhanced recovery including return of the bowel function. Both oxycodone and
naloxone orally administered are a recognized and accepted treatment option.
The objective of this study is to evaluate the implementation of an oral opioid with or
without naloxone in the early postoperative period in patients undergoing open radical
cystectomy with urinary diversion and intraoperative and early postoperative use of epidural
analgesia. The investigators expect an unchanged early return of the bowel function and
equal analgesia with a reduced length of stay of the epidural catheter (primary endpoint),
thus potentially reducing epidural catheter associated complications and lowering costs
(nursing and pain service).
Pharmacokinetics And Relative Bioavailability Study Of Oxycodone [Completed]
Abuse Liability of Controlled-Release Oxycodone Formulations [Completed]
The objective of this study is to examine the abuse liability of a single 40mg dose of 2
controlled release oxycodone formulations (Apo-Oxycodone CR® and OxyNEO®) in non-dependent
recreational opioid users by assessing the self-reported acute effects of the drugs and
taking blood samples to measure drug concentrations. The investigators think there may be
differences in how well these drugs are liked when swallowed whole due to differences in how
the products are formulated.
Comparison of the Efficacy of Oral Oxycodone and Oral Codeine in the Treatment of Postcraniotomy Pain [Completed]
The efficacy of codeine is dependent on its demethylation to morphine. This extent of
demethylation has wide inter-individual variability, making codeine's efficacy as a
analgesic variable. Oxycodone is a semi-synthetic opioid and is a weak agonist on mu opioid
receptors.
Codeine has been the mainstay of analgesia for patients after craniotomy for many years.
Traditionally, craniotomies were not thought to be very painful procedures, hence the use of
codeine, a moderately potent opioid (when compared to morphine).
However, in recent years, it has been found that up to 70% of post-craniotomy patients have
moderate to severe pain and codeine did not provide adequate analgesic relief. Many studies
have compared codeine to other drugs such as PCA morphine, fentanyl and tramadol, and
patients on these stronger opioids generally had lower pain scores and better satisfaction.
No study has been conducted to determine the efficacy of analgesia of oral oxycodone to oral
codeine.
Hence, the hypothesis is that oxycodone is more effective than codeine in providing pain
relief in post-craniotomy patients.
Comparison of the Effects of Tapentadol and Oxycodone on Gastrointestinal and Colonic Transit in Humans [Completed]
Tapentadol is FDA approved for the treatment of moderate to severe acute pain. Due to the
dual mechanism of action as an opioid agonist and norepinephrine reuptake inhibitor, there
is potential for off label use in chronic pain.
Tapentadol is a new molecular entity that is structurally similar to tramadol. Tapentadol
is a centrally-acting analgesic with a dual mode of action as an agonist at the mu-opioid
receptor and as a norepinephrine reuptake inhibitor. These two actions are synergistic in
pain relief. While its action reflects aspects of tramadol and morphine, its ability to
control pain is more on the order of hydrocodone and oxycodone.
Its dual mode of action provides analgesia at similar levels of more potent narcotic
analgesics such as hydrocodone, oxycodone, and meperidine with a more tolerable side effect
profile. Clinical studies showed that tapentadol effectively relieves moderate to severe
pain in various pain care settings. In addition, it was reported to be associated with
significantly fewer treatment discontinuations due to a significantly lower incidence of
gastrointestinal-related adverse events compared with equivalent doses of oxycodone. The
combination of these reduced treatment discontinuation rates and tapentadol efficacy for the
relief of moderate to severe nociceptive and neuropathic pain may offer an improvement in
pain therapy by increasing patient compliance with their treatment regimen.
Reports of Suspected Oxycodone and Acetaminophen (Oxycodone / Acetaminophen) Side Effects
Drug Ineffective (24),
Toxicity TO Various Agents (8),
Multiple Drug Overdose (7),
Drug Administration Error (6),
Overdose (5),
Hypotension (5),
Product Quality Issue (4),
Withdrawal Syndrome (4),
Confusional State (3),
Pain (3), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Oxycodone and Acetaminophen has an overall score of 7. The effectiveness score is 6 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
| Oxycodone and Acetaminophen review by 49 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Moderately Effective |
Side effects: | | Moderate Side Effects | | Treatment Info |
Condition / reason: | | NECK AND BACK PAIN |
Dosage & duration: | | 5 / 325 TAB MCK - FOUR TIMES PER DAY. taken 4 tablets per day- every six hours for the period of FOR 2 & 1/2 MONTHS AND STILL TAKING IT. |
Other conditions: | | NONE |
Other drugs taken: | | NAPROXEN SODIUM | | Reported Results |
Benefits: | | IT WORKED FOR RELIEVING SOME OF MY NECK AND BACK PAIN. PLEASE NOTE, MY CAUSE OF PAIN WAS DUE TO SURGERY PAIN AND NOT YOUR NORMAL KIND OF BACK PAIN. I MUST SAY THAT IT JUST KIND OF TOOK THE EDGE OFF OF THE SEVERE PAIN I WAS FEELING.
AS TIME WENT ON I BEGAN TO HEAL AND FEEL MUCH BETTER AND NOW IT TENDS TO WORK MUCH BETTER. |
Side effects: | | SOMETIMES TROUBLE BREATHING AND TROUBLE URINATING. ALSO, FELT DROWSY DURING THE DAY. THE BREATHING AND THE URINATING PROBLEMS STOPPED AFTER ABOUT A WEEK ON THIS MEDICATION. AS FOR THE DROWSY FEELING, I STILL EXPERIENCE THAT AND TRY NOT TO DRIVE WHILE ON THIS MEDICATION. I EXPERIENCE NO OTHER SIDE EFFECT EVEN THOUGH I AM STILL TAKING THE MEDICATION. |
Comments: | | DUE TO A SLIP AND FALL ACCIDENT, I NEEDED TO GET BACK SURGERY FOR MY CONDITION.
THE TYPE OF SURGERY I HAD WAS CALLED ANTERIOR CERVICAL DISKECTOMY AND FUSION FOR CERVICAL DISC DISPLACEMENT. THE DOCTOR PRESCRIBED OXYCODONE ALONG WITH NAPROXEN. I RARELY TOOK THE NAPROXEN BUT TOOK THE OXYCODONE FOUR TIMES A DAY FOR TWO MONTHS. AT THIS TIME, I STILL TAKE THE MEDICATION ONLY WHEN I FEEL I NEED IT - APPROXIMATELY ONCE OR TWICE A DAY.
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Page last updated: 2015-08-10
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