OXSORALEN SUMMARY
OXSORALEN® LOTION 1%
(Methoxsalen USP, 1%)
Rx Only
Each ml. of Oxsoralen Lotion contains 10 mg. methoxsalen in an inert vehicle containing alcohol (71% v/v), propylene glycol, acetone, and purified water. Methoxsalen is a naturally occurring substance found in the seeds of the Ammi majus (Umbelliferae) plant and in the roots of Heracleum Candicans. It belongs to a group of compounds known as psoralens or furocou-marins.
OXSORALEN (Methoxsalen TOPICAL) is indicated for the following:
As a topical repigmenting agent in vitiligo in conjunction with controlled doses of ultraviolet A (320-400 nm) or sunlight.
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NEWS HIGHLIGHTSMedia Articles Related to Oxsoralen (Methoxsalen Topical)
Cure For Gray Hair And Vitiligo Found
Source: Dermatology News From Medical News Today [2013.05.05]
A modified pseudocatalase, a new compound that reverses oxidative stress may provide a cure for loss of skin or hair color, i.e. gray hair or vitiligo, researchers from the United Kingdom and Germany reported in The FASEB Journal. The need to use hair dyes to cover up a classic sign of aging - gray hair - may soon be a thing of the past...
Experimental Vitiligo Treatment Shows Promise in Mice
Source: MedicineNet Vitiligo Specialty [2013.02.28]
Title: Experimental Vitiligo Treatment Shows Promise in Mice
Category: Health News
Created: 2/27/2013 2:36:00 PM
Last Editorial Review: 2/28/2013 12:00:00 AM
Skin Cell Transplant May Offer New Hope to Vitiligo Patients
Source: MedicineNet Vitiligo Specialty [2012.06.25]
Title: Skin Cell Transplant May Offer New Hope to Vitiligo Patients
Category: Health News
Created: 6/22/2012 2:05:00 PM
Last Editorial Review: 6/25/2012 12:00:00 AM
Vitiligo
Source: MedicineNet Achalasia Specialty [2010.08.01]
Title: Vitiligo
Category: Diseases and Conditions
Created: 7/11/1999 5:59:00 AM
Last Editorial Review: 8/1/2010 12:00:00 AM
Published Studies Related to Oxsoralen (Methoxsalen Topical)
Randomized, double-blind comparison of 1 mg/L versus 5 mg/L methoxsalen bath-PUVA therapy for chronic plaque-type psoriasis. [2006.10]
BACKGROUND: Bath-psoralen plus ultraviolet A (PUVA) radiation therapy is increasingly replacing oral PUVA because of its superior short- and long-term safety profile. Several investigations in recent years have led to a refinement of the bath-PUVA protocol; however, the optimal therapeutic concentration of methoxsalen in the bath water has as yet not been delineated. OBJECTIVES: The therapeutic efficacy and tolerability of bath-PUVA by using two different dilutions of methoxsalen (1 mg/L vs 5 mg/L or 0.0001% vs 0.0005%) were compared in 46 patients with chronic plaque-type psoriasis in a prospective, randomized, double-blind study... CONCLUSIONS: Our data indicate that in bath-PUVA treatment the use of a high (5 mg/L) methoxsalen concentration is substantially more effective in clearing chronic plaque-type psoriasis than a low (1 mg/L) concentration.
Drug-drug interaction after single oral doses of the furanocoumarin methoxsalen and cyclosporine. [2006.07]
Furanocoumarins increase the bioavailability of drugs that are CYP3A4 substrates. A possible interaction of methoxsalen with cyclosporine was evaluated in 12 healthy volunteers following oral administration of 40 mg methoxsalen, 200 mg cyclosporine, or a combination of both in a randomized crossover study...
Clinical Trials Related to Oxsoralen (Methoxsalen Topical)
A Safety and Efficacy Study of Uvadex and Extracorporeal Photopheresis (ECP) in Chronic Graft Versus Host Disease [Recruiting]
The purpose of this study is to evaluate the safety and effectiveness of extracorporeal
photopheresis therapy when added to standard drug therapies administered to patients with
moderate to severe chronic graft-versus-host disease.
PUVA Maintenance Therapy in Mycosis Fungoides [Not yet recruiting]
The purpose of the study is to determine whether psoralen plus UVA (PUVA) photochemotherapy
maintenance treatment prolongs disease-free survival of cutaneous T cell lymphoma (mycosis
fungoides) patients.
Fumaric Acid Ester-PUVA Therapy Versus Acitretin -PUVA Therapy in Pustular Palmoplantar Psoriasis [Recruiting]
The purpose of this prospective, randomized, controlled, single-blinded investigation is to
study the efficacy, tolerability and safety of oral photochemotherapy (PUVA) combined with
acitretin versus oral PUVA combined with systemic fumaric acid esters (FAE) in patients with
pustular palmoplantar psoriasis.
Patients will be randomized and allocated in concealed manner to one of the two treatment
arms: acitretin-PUVA or FAE-PUVA.
RHIV A Pilot Study Refractory or Intolerant to Highly Active Antiretroviral Therapy (HAART) [Recruiting]
The objectives of this clinical trial are to:
- Assess the safety of using extracorporeal photoimmune therapy with the photosensitizing
agent Uvadex in the treatment of HIV-1 infection;
- Evaluate the effects of this therapy on HIV-1 viral load by polymerase chain reaction
(PCR) analysis;
- Evaluate the effects of this therapy on CD4+, CD8+ cells and CD4/CD8 ratio;
- Evaluate the effects of this therapy on the patient's immune system, by skin reactivity
to a standard anergy panel.
Safety and Efficacy Study of Photopheresis With UVADEX to Prevent Graft-Versus-Host Disease [Active, not recruiting]
The purpose of this study is to determine whether Extracorporeal Photopheresis with UVADEX
(ECP) prior to bone marrow or peripheral blood stem cell transplantation is effective in the
prevention of Graft-versus-Host Disease (GvHD).
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