OXAZEPAM SUMMARY
Oxazepam is the first of a chemical series of compounds known as
the 3-hydroxybenzodiazepinones. A therapeutic agent providing versatility and
flexibility in control of common emotional disturbances, this product exerts
prompt action in a wide variety of disorders associated with anxiety, tension,
agitation, and irritability, and anxiety associated with depression.
Oxazepam is indicated for the management of anxiety disorders or
for the short-term relief of the symptoms of anxiety. Anxiety or tension
associated with the stress of everyday life usually does not require treatment
with an anxiolytic.
Anxiety associated with depression is also responsive to Oxazepam
therapy.
This product has been found particularly useful in the management of anxiety,
tension, agitation, and irritability in older patients.
Alcoholics with acute tremulousness, inebriation, or with anxiety, associated
with alcohol withdrawal are responsive to therapy.
The effectiveness of Oxazepam in long-term use, that is, more than 4 months,
has not been assessed by systematic clinical studies. The physician should
periodically reassess the usefulness of the drug for the individual patient.
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NEWS HIGHLIGHTSMedia Articles Related to Oxazepam
Chronic Pain Common in Adults With Depression, Anxiety Source: MedicineNet Bipolar Disorder Specialty [2017.06.07] Title: Chronic Pain Common in Adults With Depression, Anxiety Category: Health News Created: 6/6/2017 12:00:00 AM Last Editorial Review: 6/7/2017 12:00:00 AM
Generalized Anxiety Disorder Source: MedicineNet alprazolam Specialty [2017.05.30] Title: Generalized Anxiety Disorder Category: Symptoms and Signs Created: 2/20/2014 12:00:00 AM Last Editorial Review: 5/30/2017 12:00:00 AM
Anxiety Source: MedicineNet Holiday Depression And Stress Specialty [2017.05.01] Title: Anxiety Category: Symptoms and Signs Created: 10/13/2003 12:00:00 AM Last Editorial Review: 5/1/2017 12:00:00 AM
Anxiety Disorder Pictures: Symptoms, Panic Attacks, and More with Pictures Source: MedicineNet temazepam Specialty [2016.06.09] Title: Anxiety Disorder Pictures: Symptoms, Panic Attacks, and More with Pictures Category: Slideshows Created: 2/2/2012 12:00:00 AM Last Editorial Review: 6/9/2016 12:00:00 AM
Positive Topline Results for Cannabinoid Gel in Fragile X Source: Medscape NeurologyHeadlines [2017.09.29] An investigational transdermal cannabinoid gel led to significant and clinically meaningful improvement in anxiety and difficult behaviors in a phase 2 study of children with fragile X syndrome. Medscape Medical News
Published Studies Related to Oxazepam
Sodium oxybate in the treatment of alcohol withdrawal syndrome: a randomized
double-blind comparative study versus oxazepam. The GATE 1 trial. [2014] AWS... CONCLUSION: SMO is as effective as oxazepam, one of the gold standard BDZs, in
Effects of oxazepam on affective perception, recognition, and event-related potentials. [2011.05] BACKGROUND: Little is known about how rapid electrocortical responses (event-related potentials; ERPs) to affective pictures are modulated by benzodiazepine agonists. The present study investigated effects of oxazepam (20 mg p.o.) on behavioral measures and ERPs associated with affective picture processing during perception and recognition memory retrieval... CONCLUSIONS: Oxazepam does not selectively influence electrocortical or perceptual indexes of emotional perception or emotional memory. Rather, it blocks memory consolidation independent of valence category. These findings indicate that ERPs can be of use in assessing effects of benzodiazepines on memory-related processes.
Oxazepam does not modulate the behavioral effects of d-amphetamine in humans. [2005.10] Benzodiazepines, which are gamma-aminobutyric acid-A (GABA(A)) receptor positive modulators, can block the behavioral effects of psychomotor stimulants. In the present study, the ability of oxazepam, which may have less abuse potential compared to some other benzodiazepines, to attenuate the discriminative-stimulus, subject-rated and psychomotor performance effects of d-amphetamine in humans was determined...
Effects of additional oxazepam in long-term users of oxazepam. [2005.02] Although additional dosages of benzodiazepines in long-term users of benzodiazepines are common, it is unknown whether these additional dosages resort any effect. The effects of an additional 20-mg dosage oxazepam were assessed in a double-blind, balanced-order, crossover randomized study comparing 16 long-term users of oxazepam (patients) with 18 benzodiazepine-naive controls (controls)...
Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study. [2002.11.25] Patients aged 18 to 73 years and diagnosed with non-organic insomnia according to ICD-10 (F 51.0) were treated in a multicentre, double-blind, randomised parallel group comparison with either 600 mg/die valerian extract LI 156 (Sedonium) or 10 mg/die oxazepam taken for 6 weeks... During the 6 week treatment phase Valerian extract LI 156 (Sedonium) 600 mg/die showed a comparable efficacy to 10 mg/die oxazepam in the therapy of non-organic insomnia.
Clinical Trials Related to Oxazepam
Comparative Study of Gamma-hydroxy Butyrate Versus Oxazepam in the Treatment of Alcohol Withdrawal Syndrome [Completed]
Benzodiazepines (BDZs) are the gold standard in the treatment of alcohol withdrawal syndrome
(AWS). Gamma-Hydroxybutyric acid also known as sodium oxybate (SMO) has been tested as a
treatment for AWS with encouraging results. Aim of this phase IV, multicenter randomized
double-blind, double dummy study is to evaluate the efficacy of SMO in comparison to
oxazepam in the treatment of alcohol withdrawal symptoms (AWS).
Single and Multiple Rising Dose Study of Safety and PK of Metyrapone/Oxazepam Combination (EMB-001) [Recruiting]
This is a study of EMB-001 (a combination of two FDA-approved drugs, metyrapone and
oxazepam) in otherwise healthy adults who are regular cigarette smokers. There will be 3
groups of 8 subjects; in each group, 6 subjects will get the drug combination and 2 will get
placebo. Neither the subjects nor the study personnel will know who got drug and who got
placebo (double-blind). In the first group the drug doses will be low, and they will be
increased in the second and third groups. Subjects will receive a single dose on Day 1,
followed 24 hours later by the start of doses twice daily for 7 days, and then a final
morning dose on the last day. The levels of the drugs in the blood will be assessed by
repeated blood draws after the first day and after the end of dosing. Safety will be
assessed after the single dose and repeated dosing. Effects of study drug on smoking and
craving cigarettes will be assessed at the end of repeated dosing. The hypothesis is that
this drug combination will be safe, with relatively few side effects.
The Pharmacokinetics of Zidovudine and Oxazepam Alone and in Combination in the HIV-Infected Patient [Completed]
To determine if a pharmacokinetic (blood level) interaction exists between zidovudine (AZT)
and oxazepam in the HIV-infected patient. Benzodiazepines (such as oxazepam) are among the
most frequently prescribed class of drugs and are commonly used therapeutically for patients
with chronic disease. This study is important because of the potential for toxicity
resulting from a reaction between AZT and benzodiazepines and the likelihood of frequent use
of the combination of these drugs in patients with HIV infection.
A Placebo-Controlled Study of a Combination of Metyrapone and Oxazepam in Cocaine Addiction [Completed]
Subjects will be randomly assigned to receive either one of the two potential dose
combinations of the study medications or placebo over 6 weeks. The study will include twice
weekly visits to the research clinic for laboratory studies, safety assessments and urine
drug screens. Subjects will also be questioned regarding drug craving and mood symptoms.
Study to Evaluate the Presence of a Hangover Effect in Healthy Adults After Administration of Songha® Night Tablets [Completed]
Reports of Suspected Oxazepam Side Effects
Toxicity TO Various Agents (48),
Drug Interaction (23),
Confusional State (19),
Suicide Attempt (13),
Disorientation (11),
Overdose (11),
Delirium (11),
Agitation (10),
Fall (10),
Medication Error (10), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 4 ratings/reviews, Oxazepam has an overall score of 6.50. The effectiveness score is 7.50 and the side effect score is 6.50. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| Oxazepam review by 46 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Highly Effective |
Side effects: | | Mild Side Effects | | Treatment Info |
Condition / reason: | | Anxiety due to Relationship Stress |
Dosage & duration: | | 10mg twice per day taken only as needed for stress for the period of 6 months irregularly; as needed |
Other conditions: | | None |
Other drugs taken: | | None | | Reported Results |
Benefits: | | I would get heart palpitations and major stress hours before my ex would come and pick up our daughter for visits; I also had difficulty sleeping if I had to deal with any issues with him; I would take one of these pills, only if I felt I needed and sometimes an hour before he would pick her up, and I would feel much calmer. It was a life saver for me until I got through the emotional upset and was able to detach. |
Side effects: | | Virtually no side effects, other than very slight drowsiness several hours after taking it...almost not noticeable. |
Comments: | | I was on a very small dose. And I only took this when I felt I needed it. It was a life saver and kept my body from experiencing intense stress like shaking, heart palpitations, and emotional upset. It did not change my mood. It only controlled the negative physical effect that I was allowing this person to have on me. |
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| Oxazepam review by care giver of 85 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Ineffective |
Side effects: | | Extremely Severe Side Effects | | Treatment Info |
Condition / reason: | | temporary anxiety |
Dosage & duration: | | 30mg taken daily for the period of 5 years |
Other conditions: | | none |
Other drugs taken: | | none | | Reported Results |
Benefits: | | My father was put on this drug to fend off temporary, situational anxiety when his wife developed alzheimer's and was not looking after the finances properly. It helped him to sleep better. In the meantime, our family helped them sort out the financial mess his wife had created in her confusion.
His anxiety ended but the doctor forgot to take him off the drug at the end of the 4 month period of effectiveness. |
Side effects: | | After 5 years of taking this drug, my father has developed short term memory loss which has developed to the point he now has an alzheimer's diagnosis for himself. He has no other symptoms of AD, just short term memory loss after 5 years on a drug that is only proven 'effective' for 4 months. |
Comments: | | Due to a recent mix up at the pharmacy, my father was accidentally withdrawn from the drug and suffered a terrible withdrawal. After 10 days without oxazepam, his memory improved but the doctor put him right back on it. I have since tried to get the doc to take him off. His answer? What's the point at his age. Why not just let him drift away in a foggy twilight.
I love my dad and think he deserves better so I'm fighting this situation, but meanwhile my father wakes up each day wondering why he is on an advanced alzheimer's ward when he has no symptoms beyond drug induced short term memory loss.
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| Oxazepam review by care giver of 85 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Ineffective |
Side effects: | | Extremely Severe Side Effects | | Treatment Info |
Condition / reason: | | temporary anxiety |
Dosage & duration: | | 30mg taken daily for the period of 5 years |
Other conditions: | | none |
Other drugs taken: | | none | | Reported Results |
Benefits: | | My father was put on this drug to fend off temporary, situational anxiety when his wife developed alzheimer's and was not looking after the finances properly. It helped him to sleep better. In the meantime, our family helped them sort out the financial mess his wife had created in her confusion.
His anxiety ended but the doctor forgot to take him off the drug at the end of the 4 month period of effectiveness. |
Side effects: | | After 5 years of taking this drug, my father has developed short term memory loss which has developed to the point he now has an alzheimer's diagnosis for himself. He has no other symptoms of AD, just short term memory loss after 5 years on a drug that is only proven 'effective' for 4 months. |
Comments: | | Due to a recent mix up at the pharmacy, my father was accidentally withdrawn from the drug and suffered a terrible withdrawal. After 10 days without oxazepam, his memory improved but the doctor put him right back on it. I have since tried to get the doc to take him off. His answer? What's the point at his age. Why not just let him drift away in a foggy twilight.
I love my dad and think he deserves better so I'm fighting this situation, but meanwhile my father wakes up each day wondering why he is on an advanced alzheimer's ward when he has no symptoms beyond drug induced short term memory loss.
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Page last updated: 2017-09-29
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