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Ovace Plus Shampoo (Sulfacetamide Sodium) - Description and Clinical Pharmacology

 
 



ACTIVE INGREDIENT:
Sodium Sulfacetamide 10% w/w.

INACTIVE INGREDIENTS:
Citric Acid, Cocamide MEA, Ethoxydiglycol, Fragrance, Glycol Distearate, Magnesium Aluminum Silicate, Methylchloroisothiazolinone, Methylisothiazolinone, PEG-150 Distearate, Purified Water (Aqua), Sodium Chloride, Sodium Laureth Sulfate, Xanthan Gum.

Sulfacetamide sodium is C8H9N2NaO3S·H2O with molecular weight of 254.24. Chemically, it is Acetamide N-[4-aminophenyl)sulfonyl]-, monosodium salt, monohydrate, with the following structural formula:

Sulfacetamide sodium is an odorless, white, crystalline powder with a bitter taste. It is freely soluble in water, sparingly soluble in alcohol, while practically insoluble in benzene, in chloroform or in ether.

CLINICAL PHARMACOLOGY:

Sulfacetamide sodium exerts a bacteriostatic effect against sulfonamide sensitive Gram-positive and Gram-negative microorganisms commonly isolated from secondary cutaneous pyogenic infections. It acts by restricting the synthesis of folic acid required by bacteria for growth, by its competition with para-aminobenzoic acid. There are no clinical data available on the degree and rate of systemic absorption of Ovace® Plus Shampoo when applied to the skin or scalp. However, significant absorption of sulfacetamide sodium through the skin has been reported.

The following in vitro data are available but their clinical significance is unknown. Organisms that show susceptibility to sulfacetamide sodium are: Streptococci, Staphylococci, E. coli, Klebsiella pneumoniae,Pseudomonas pyocyanea, Salmonella species, Proteus vulgaris, Nocardia and Actinomyces.

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