OSMITROL Injection (Mannitol Injection, USP) is contraindicated in patients with:
Well established anuria due to severe renal disease,
Severe pulmonary congestion or frank pulmonary edema,
Active intracranial bleeding except during craniotomy,
Progressive renal damage or dysfunction after institution of mannitol therapy, including increasing oliguria and azotemia, and
Progressive heart failure or pulmonary congestion after institution of mannitol therapy.