NEWS HIGHLIGHTS
Published Studies Related to Oruvail Extended-Release (Ketoprofen)
Comparing the efficacy of intravenous tenoxicam, lornoxicam, and dexketoprofen
trometamol for the treatment of renal colic. [2012]
dexketoprofen trometamol-for the treatment of patients with renal colic... CONCLUSIONS: Intravenous tenoxicam, lornoxicam, and dexketoprofen are all
Postoperative analgesic efficacy of intravenous dexketoprofen in lumbar disc surgery. [2011.07]
BACKGROUND: We investigated the postoperative analgesic efficacy and effect on total tramadol consumption of intravenous dexketoprofen trometamol, a new nonsteroidal anti-inflammatory drug, in patients that had undergone lumbar disc surgery... CONCLUSION: We found that dexketoprofen was an effective analgesic for postdiscectomy pain when used alone or in addition to opioids. It is easy to administer and decreases tramadol consumption and opioid-related side effects.
Clinical evaluation of meloxicam versus ketoprofen in cats suffering from painful acute locomotor disorders. [2011.04]
The aim of this study was to evaluate the efficacy and palatability of meloxicam 0.5mg/ml oral suspension, compared to ketoprofen tablets in cats suffering from painful acute locomotor disorders. This single blinded, positively-controlled, randomised, multicentre trial involved 121 client owned cats...
[Pre-emptive ketoprofen for postoperative pain relief after urologic surgery]. [2011.01]
BACKGROUND: Effective multimodal postoperative analgesia is one of determinants of patient satisfaction after successful surgery. Following the recommendations of non-steroidal antiinflammatory agents (NSAIDs) for pre-emptive analgesia, we assessed the efficacy of ketoprofen administered before urological surgery... CONCLUSION: Pre-emptive analgesia with intravenous ketoprofen was ineffective in patients undergoing urological surgery.
[The effects of preemptive dexketoprofen use on postoperative pain relief and tramadol consumption]. [2011.01]
OBJECTIVES: In this study, the efficacy of preemptive dexketoprofen usage on postoperative pain relief and tramadol consumption was evaluated... CONCLUSION: Preemptive use of dexketoprofen reduced postoperative tramadol consumption and incidence of adverse events.
Clinical Trials Related to Oruvail Extended-Release (Ketoprofen)
Trial on Metoclopramide and Ketoprofen in Acute Migraine of Childhood [Not yet recruiting]
This is a Randomized double blind trial with the aim to estimate the effectiveness of 3
therapeutic regimes per os on migraine pain:
- metoclopramide 0,15 mg/kg + placebo
- metoclopramide 0,15 mg/Kg + ketoprofen 1 mg/kg
- ketoprofen 1 mg/Kg + placebo
Intensity of pain will be measured with linear 1-10 scale or analogic McGrath type scale
every 20 min.
The main objective is the evaluation of healing times from pain in the 3 groups
Study to Assess the Efficacy and Safety of Ibuprofen 50 mg/g Gel Compared to Profenid 25mg/g Gel [Not yet recruiting]
The aim of this study is to determine that ibuprofen 50mg/g gel is effective and safety
treating patients with muscle aches, joint pains or due to sprains, bruises, tendinitis or
myofascial compared to Profenid 25mg/g gel.
Evaluation of Inflammatory Symptoms Reduction With Amoxicillin + Ketoprofen in Acute Pharyngeal- Tonsillitis in Pediatric Patients [Recruiting]
The purpose of this study is to evaluate the inflammatory symptoms and signs (hyperemia,
edema and pain) reduction after 24 hours of treatment with ketoprofen drops when associated
to amoxicillin.
Topical Intra-Oral Ketoprofen for Migraine Prevention [Recruiting]
Intra-Oral Topical Ketoprofen gel, applied to a branch of the trigeminal nerve, has been
shown to prevent migraines when used once daily for 3 months in open label studies. This is
a randomized, double-blind, placebo controlled phase III prevention trial to determine
safety and efficacy.
Study of Non Inferiority Bi-Profenid® 200mg Versus Bi-Profenid® 300mg Among Patients Presenting of the Post-Traumatic or Rheumatologic Acute Affections of the Locomotor Apparatus (BIPROPAIN) [Recruiting]
Primary objective:
To demonstrate the non-inferiority of Bi-Profenid 100 mg x 2 day versus Bi-Profenid 150 mg x
2 day in patients presenting with pain related to closed, benign, acute post-traumatic
conditions of the motor system or acute, non-infectious rheumatologic conditions, by
comparing, on the one hand, changes in resting pain intensity over the entire day, measured
at the end of the day using a numeric scale (NS), over 5 days and, on the other hand, total
intake over 5 days of concomitant analgesics.
Secondary Objectives:
- To describe concomitant analgesic treatments
- To describe the time between baseline and use of a step I, II or III analgesic
- To evaluate patients pain relief using a Likert 4-class scale (complete or substantial
relief, moderate relief slight relief and absence of relief) at D5
- To evaluate changes in intensity of pain when moving, over the entire day, measured at
the end of the day using a numeric scale, over 5 days
- To evaluate the patients overall satisfaction at the end of treatment using a 4-point
Simple Verbal Scale (SVS) (very satisfied, somewhat satisfied, somewhat unsatisfied,
very unsatisfied)
- To evaluate the patients overall satisfaction at the end of the study using a 4-point
Simple Verbal Scale (EVS) (very satisfied, somewhat satisfied, somewhat unsatisfied,
very unsatisfied)
- To compare the safety of the two treatments
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