• NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction (MI), and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk. (See WARNINGS).
• Orudis and Oruvail are contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery. (See WARNINGS).
• NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal (GI) events. (See WARNINGS).
Published Studies Related to Oruvail Extended-Release (Ketoprofen)
Comparing the efficacy of intravenous tenoxicam, lornoxicam, and dexketoprofen
trometamol for the treatment of renal colic. 
dexketoprofen trometamol-for the treatment of patients with renal colic... CONCLUSIONS: Intravenous tenoxicam, lornoxicam, and dexketoprofen are all
Postoperative analgesic efficacy of intravenous dexketoprofen in lumbar disc surgery. [2011.07]
BACKGROUND: We investigated the postoperative analgesic efficacy and effect on total tramadol consumption of intravenous dexketoprofen trometamol, a new nonsteroidal anti-inflammatory drug, in patients that had undergone lumbar disc surgery... CONCLUSION: We found that dexketoprofen was an effective analgesic for postdiscectomy pain when used alone or in addition to opioids. It is easy to administer and decreases tramadol consumption and opioid-related side effects.
Clinical evaluation of meloxicam versus ketoprofen in cats suffering from painful acute locomotor disorders. [2011.04]
The aim of this study was to evaluate the efficacy and palatability of meloxicam 0.5mg/ml oral suspension, compared to ketoprofen tablets in cats suffering from painful acute locomotor disorders. This single blinded, positively-controlled, randomised, multicentre trial involved 121 client owned cats...
[Pre-emptive ketoprofen for postoperative pain relief after urologic surgery]. [2011.01]
BACKGROUND: Effective multimodal postoperative analgesia is one of determinants of patient satisfaction after successful surgery. Following the recommendations of non-steroidal antiinflammatory agents (NSAIDs) for pre-emptive analgesia, we assessed the efficacy of ketoprofen administered before urological surgery... CONCLUSION: Pre-emptive analgesia with intravenous ketoprofen was ineffective in patients undergoing urological surgery.
[The effects of preemptive dexketoprofen use on postoperative pain relief and tramadol consumption]. [2011.01]
OBJECTIVES: In this study, the efficacy of preemptive dexketoprofen usage on postoperative pain relief and tramadol consumption was evaluated... CONCLUSION: Preemptive use of dexketoprofen reduced postoperative tramadol consumption and incidence of adverse events.
Clinical Trials Related to Oruvail Extended-Release (Ketoprofen)
Evaluation of Inflammatory Symptoms Reduction With Amoxicillin + Ketoprofen in Acute Pharyngeal- Tonsillitis in Pediatric Patients [Recruiting]
The purpose of this study is to evaluate the inflammatory symptoms and signs (hyperemia,
edema and pain) reduction after 24 hours of treatment with ketoprofen drops when associated
Topical Intra-Oral Ketoprofen for Migraine Prevention [Recruiting]
Intra-Oral Topical Ketoprofen gel, applied to a branch of the trigeminal nerve, has been
shown to prevent migraines when used once daily for 3 months in open label studies. This is
a randomized, double-blind, placebo controlled phase III prevention trial to determine
safety and efficacy.
Study of Non Inferiority Bi-Profenid® 200mg Versus Bi-Profenid® 300mg Among Patients Presenting of the Post-Traumatic or Rheumatologic Acute Affections of the Locomotor Apparatus (BIPROPAIN) [Recruiting]
To demonstrate the non-inferiority of Bi-Profenid 100 mg x 2 day versus Bi-Profenid 150 mg x
2 day in patients presenting with pain related to closed, benign, acute post-traumatic
conditions of the motor system or acute, non-infectious rheumatologic conditions, by
comparing, on the one hand, changes in resting pain intensity over the entire day, measured
at the end of the day using a numeric scale (NS), over 5 days and, on the other hand, total
intake over 5 days of concomitant analgesics.
- To describe concomitant analgesic treatments
- To describe the time between baseline and use of a step I, II or III analgesic
- To evaluate patients pain relief using a Likert 4-class scale (complete or substantial
relief, moderate relief slight relief and absence of relief) at D5
- To evaluate changes in intensity of pain when moving, over the entire day, measured at
the end of the day using a numeric scale, over 5 days
- To evaluate the patients overall satisfaction at the end of treatment using a 4-point
Simple Verbal Scale (SVS) (very satisfied, somewhat satisfied, somewhat unsatisfied,
- To evaluate the patients overall satisfaction at the end of the study using a 4-point
Simple Verbal Scale (EVS) (very satisfied, somewhat satisfied, somewhat unsatisfied,
- To compare the safety of the two treatments
Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury [Not yet recruiting]
Transdel Pharmaceuticals is investigating a topical cream formulation consisting of 10%
ketoprofen for the local treatment of pain associated with mild to moderate acute soft
tissue injury in this confirmatory Phase 3 trial.
Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Tissue Injury [Recruiting]