NEWS HIGHLIGHTS
Published Studies Related to Ortho-Cept (Desogestrel / Ethinyl Estradiol)
Effects of two combined oral contraceptives containing ethinyl estradiol 20 microg combined with either drospirenone or desogestrel on lipids, hemostatic parameters and carbohydrate metabolism. [2005.06]
OBJECTIVE: To compare the effect of ethinyl estradiol 20 microg/drospirenone 3 mg (EE 20 microg/DRSP 3 mg) administered according to a 24/4 regimen with ethinyl estradiol 20 microg/desogestrel 150 microg (EE 20 microg/DSG 150 microg) administered according to the conventional 21/7 regimen on lipid, carbohydrate and hemostatic parameters... CONCLUSION: EE 20 microg/DRSP 3 mg has a good safety profile comparable with EE 20 microg/DSG 150 microg.
Serum resistin levels in women taking combined oral contraceptives containing desogestrel or gestodene. [2004.06]
Resistin is a hormone secreted by adipose tissue that could be involved in the development of insulin resistance. Previous studies confirmed that endogenous sex steroids may influence serum resistin concentration in women... We conclude that ethinylestradiol combined with desogestrel or gestodene is unlikely to induce insulin resistance through resistin pathway.
A randomized study on the influence of oral contraceptives containing ethinylestradiol combined with drospirenone or desogestrel on lipid and lipoprotein metabolism over a period of 13 cycles. [2004.04]
In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (EE + DRSP = Yasmin), with a reference preparation containing 30 microg ethinylestradiol and 150 microg desogestrel (EE + DSG = Marvelon) on the lipid profile.
Glucose metabolism and insulin resistance in women with polycystic ovary syndrome during therapy with oral contraceptives containing cyproterone acetate or desogestrel. [2003.08]
Oral contraceptives slightly deteriorate insulin sensitivity. The present study investigated whether they may further unbalance the glucose metabolism of lean women with polycystic ovary syndrome (PCOS)... The long-term metabolic effects of these two compounds on women with PCOS require further investigations.
A randomized study over 13 cycles to assess the influence of oral contraceptives containing ethinylestradiol combined with drospirenone or desogestrel on carbohydrate metabolism. [2003.06]
In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (Yasmin) with a reference preparation containing 30 microg ethinylestradiol and 150 microg desogestrel (Marvelon) on variables of carbohydrate metabolism by means of oral glucose tolerance tests at baseline and in the 6th and 13th treatment cycle...
Clinical Trials Related to Ortho-Cept (Desogestrel / Ethinyl Estradiol)
NuvaRing Versus Marvelon in the Coordination of In Vitro Fertilization Cycles [Recruiting]
Presently, a long protocol in an In Vitro Fertilization (IVF) cycle, patients need to take
Marvelon, a drug that inhibits the follicular development at the beginning of the cycle in
order to better control and also plan the onset of the ovary stimulation with gonadotropin.
Marvelon is taken daily as soon as menstruation starts for a period of 14 to 21 days.
Ideally, it has to be taken at the same time everyday and not be forgotten. This may cause
higher stress level for some users. Presently on the market, there is a ring-shaped
contraceptive device inserted in the vagina at day 1 of the cycle called NuvaRing. The
purpose of this device is similar to an oral contraceptive. However, the benefit of NuvaRing
is that it can be left in place for a period of up to 35 days without any other manipulation
and keep an adequate rate of hormone for contraception. Moreover, NuvaRing shows better
hormone stability in the blood. Although the side effects and the benefits are comparable
for the two treatments, some studies have shown that more patients would respect the
treatment with NuvaRing and that the level of satisfaction would be higher in women using
NuvaRing when contraception is needed.
The purpose of the study is to compare the rate of satisfaction as well as the level of
stress in women using Marvelon daily or NuvaRing with single insertion in a long protocol.
Moreover, this study allow us to verify if using NuvaRing, a vaginal contraceptive releasing
constant daily doses for up to 35 days will allow us to facilitate the planning of In Vitro
Fertilization cycles in long protocol.
New Treatments for Troublesome Bleeding in Implanon Users [Not yet recruiting]
Most Implanon users experience a reduction in the frequency and volume of menstrual
bleeding, but a substantial minority experience unpredictable and frequent and/or prolonged
episodes of bleeding. This is a double blind, placebo controlled, randomised study with an
additional randomised non-blinded arm. Two hundred women between the ages of 18-45 years,
who are Implanon users with prolonged or frequent breakthrough bleeding (WHO definition)
will be recruited and randomised into 4 equal-sized treatment groups of 50 women assigned to
Marvelon 7 days or 21 days, NuvaRing 21 days or placebo. Recruited subjects will maintain a
daily menstrual diary chart for a minimum of 90 days prior to randomisation, and will be
enrolled into the treatment phase provided that they have met one of the World Health
Organization criteria for prolonged or frequent bleeding Following the initial 90 day
record, eligible women will begin designated treatment on day 1 of the next episode of
bleeding or spotting. Analysis of the subsequent menstrual pattern will begin from day 1 of
that bleeding/spotting episode and will continue through 90 days.
Continuous Versus Cyclic Use of Oral Contraceptive Pills in Adolescents [Recruiting]
The primary purpose of this study is to compare the compliance rates of adolescents who take
oral contraceptives (OCPs) continuously to those who take OCPs cyclically.
Evaluation of an Oral Contraceptive Containing 30 mg Ethinyloestradiol and 150 mg Desogestrel on Women's Health [Recruiting]
The desogestrel (150 mg) in combination with ethinyl estradiol (EE, 30 mg) is known as
Marvelon in European countries. Previous studies revealed that the Marvelon is good and safe
for women. As a study from Thailand showed that the Marvelon to be effective and acceptable
in Thai women. Moreover compared to Caucasian women, the incidences of irregular bleeding
and side effects were apparently lower in these Asian women . Although Marvelon was used in
many countries but it's efficacy didn't reported among Iranian women.
A Study of Efficacy and Safety With the Transdermal Contraceptive System Versus Mercilon. [Completed]
The purpose of the study was to compare the contraceptive efficacy and safety of the
transdermal patch to Mercilon.
Reports of Suspected Ortho-Cept (Desogestrel / Ethinyl Estradiol) Side Effects
Pulmonary Embolism (9),
Thrombosis (4),
Intracardiac Thrombus (4),
Hypercoagulation (4),
Pain in Extremity (2),
Syncope (2),
Pulmonary Hypertension (1),
OFF Label USE (1),
Smear Cervix Abnormal (1),
Uterine Leiomyoma (1), more >>
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