Orphenadrine (Orphenadrine Citrate) - Description and Clinical Pharmacology

DESCRIPTION

Orphenadrine Citrate Injection is a sterile aqueous solution of orphenadrine citrate. It is intended for intravenous or intramuscular administration.

Orphenadrine citrate is the citrate salt of orphenadrine and occurs as a white, crystalline powder having a bitter taste. It is practically odorless, sparingly soluble in water and slightly soluble in alcohol. It has the following structural formula:

C₁₈H₂₃NO.C₆H₈O₇       MW 461.51

N,N-Dimethyl-2-[(o -methyl-α-phenylbenzyl)oxy]ethylamine Citrate (1:1).

Each mL contains: Orphenadrine Citrate 30 mg, Sodium Metabisulfite 0.91 mg, Sodium Chloride 2.9 mg, in Water for Injection q.s. Sodium Hydroxide and/or Hydrochloric Acid may have been used to adjust pH.

CLINICAL PHARMACOLOGY

The mode of action has not been clearly identified but may be related to analgesic properties. Orphenadrine citrate possesses anticholinergic actions.