OPTIVAR NEWS HIGHLIGHTS
Published Studies Related to Optivar (Azelastine Ophthalmic)
Combination therapy with azelastine hydrochloride nasal spray and fluticasone propionate nasal spray in the treatment of patients with seasonal allergic rhinitis. [2008.01]
BACKGROUND: To our knowledge, there are no published studies that evaluated the efficacy of azelastine hydrochloride nasal spray in combination with an intranasal corticosteroid, although anecdotal reports of the use of these agents in combination are common. OBJECTIVE: To determine if greater efficacy could be achieved with the intranasal antihistamine azelastine and the intranasal corticosteroid fluticasone propionate used concurrently compared with the efficacy of each agent alone... CONCLUSIONS: The significant improvement in the TNSS with combination therapy relative to the individual agents alone is in contrast to previously published studies that found no advantage with an oral antihistamine and an intranasal corticosteroid in combination. Azelastine nasal spray and fluticasone nasal spray in combination may provide a substantial therapeutic benefit for patients with seasonal allergic rhinitis compared with therapy with either agent alone.
Effect of azelastine, montelukast, and their combination on allergen-induced bronchoconstriction in asthma. [2008]
OBJECTIVES: Histamine and cysteinyl leukotrienes play an important role in early (EAR) and late (LAR) allergen reactions. Although protection by anti-histamines and anti-leukotrienes has been studied extensively, little is known about the effect of their combination. We, therefore, assessed the effect of clinically recommended doses of azelastine and montelukast alone and in combination on EAR and LAR... CONCLUSION: The combination of azelastine and montelukast in clinically recommended doses has a greater effect in suppressing early and late allergen reactions than each drug alone.
Effectiveness of azelastine nasal spray compared with oral cetirizine in patients with seasonal allergic rhinitis. [2005.05]
BACKGROUND: Azelastine nasal spray and oral cetirizine are selective histamine H(1)-receptor antagonists that are approved in the United States for the treatment of seasonal allergic rhinitis (SAR). OBJECTIVE: The objective of the present study was to compare the efficacy and tolerability of azelastine nasal spray administered at the recommended dosage of 2 sprays per nostril twice daily with those of cetirizine in the treatment of moderate to severe SAR... CONCLUSION: In this 2-week study in patients with moderate to severe SAR, azelastine nasal spray was well tolerated and produced significantly greater improvements in TNSS and total RQLQ score compared with cetirizine.
Efficacy of azelastine nasal spray in seasonal allergic rhinitis patients who remain symptomatic after treatment with fexofenadine. [2004.08]
BACKGROUND: Currently available oral second-generation antihistamines do not provide adequate symptom relief for many allergy patients. OBJECTIVE: To determine the ability of azelastine nasal spray to improve rhinitis symptoms in patients with seasonal allergic rhinitis who remained symptomatic after treatment with fexofenadine... CONCLUSIONS: Azelastine nasal spray is effective monotherapy for patients who remain symptomatic after treatment with fexofenadine and should be considered in the initial management of patients with seasonal allergic rhinitis.
Histamine skin test reactivity following single and multiple doses of azelastine nasal spray in patients with seasonal allergic rhinitis. [2003.09]
OBJECTIVE: To determine whether azelastine nasal spray suppresses the dermal response to epicutaneous histamine in allergic patients and the duration of suppression after azelastine use is discontinued... CONCLUSIONS: Azelastine nasal spray should be discontinued for at least 48 hours before beginning allergy skin test procedures.
Clinical Trials Related to Optivar (Azelastine Ophthalmic)
A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Seasonal Allergies [Completed]
The purpose of this study is to determine if two allergy medications (azelastine and
fluticasone) are more effective than placebo or either medication alone (azelastine or
fluticasone)
A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Seasonal Allergies [Active, not recruiting]
The purpose of this study is to determine if two allergy medications (azelastine and
fluticasone) are more effective than placebo or either medication alone (azelastine or
fluticasone)
A Phase II Study Evaluating Intranasal GSK256066 and Azelastine Hydrochloride in Subjects With Seasonal Allergic Rhinitis [Not yet recruiting]
This study is an 8 day, randomised, double blind, 2-way crossover trial of repeat doses of
intranasal GSK256066 and azelastine hydrochloride in the Vienna Challenge Chamber in subjects
with seasonal allergic rhinitis (SAR). Laboratory safety assessments, 12-lead
electrocardiograph (ECG), vital signs and adverse event enquiries will be made throughout the
study. Nasal examination, symptom scores, and allergen challenge assessments will also be
performed at various time points throughout the study.
A Randomized, Placebo Controlled Study to Determine the Efficacy and Speed of a Nasal Spray in Allergen Induced Seasonal Allergic Rhinitis [Recruiting]
Finding out how fast azelastine nasal spray works in subjects with hay fever.
Evaluation of the Sensory Attributes of Olapatadine 0.6% and Azelastine 137mcg Nasal Sprays in Patients w/Allergic Rhinitis [Not yet recruiting]
To compare patient perceptions of the sensory attributes, including taste and aftertaste, of
Olapatadine relative to azelastine when administered as a single dose in patients with
allergic rhinitis.
|
OPTIVAR PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Optivar has an overall score of 6. The effectiveness score is 8 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
| | Optivar review by 36 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | dry, allergic eyes |
| Dosage & duration: | | 1 drop 2x/day (dosage frequency: 1x) for the period of 1x |
| Other conditions: | | eye fatigue |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | relieved some of the itching |
| Side effects: | | blurred vision for 90 seconds after administering; burning sensation |
| Comments: | | Was prescribed for 1 month for dry, itchy eyes. I took Optivar for 5 days, then called the ophtamologist about the burning sensation. He advised me to discontinue the Optivar and wrote a prescription for Alrex. |
|
|
