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Nystatin Vaginal (Nystatin Vaginal) - Description and Clinical Pharmacology

 
 



DESCRIPTION

Nystatin is an antimycotic polyene antibiotic obtained from Streptomyces noursei.

Nystatin Vaginal Tablets, USP are available as oval-shaped compressed tablets for intravaginal administration, each containing 100,000 units Nystatin, USP. Inactive ingredients include corn starch, ethylcellulose, anhydrous lactose, microcrystalline cellulose, polyethylene glycol and stearic acid.

CLINICAL PHARMACOLOGY

Nystatin is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi. Nystatin acts by binding to sterols in the cell membrane of sensitive fungi with a resultant change in membrane permeability allowing leakage of intracellular components. Nystatin exhibits no appreciable activity against bacteria, protozoa, trichomonads or viruses.

Nystatin is not absorbed from intact skin or mucous membranes.

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