NUROMAX (doxacurium chloride) is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration. Doxacurium chloride is [1α,2β(1 'S *,2 'R *)]-2,2 ' -[(1,4-dioxo-1,4-butanediyl)bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7,8-trimethoxy-2- methyl-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinolinium] dichloride (meso form).
NUROMAX is a long-acting neuromuscular blocking agent, indicated to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation.
Media Articles Related to Nuromax (Doxacurium)
Researchers determine best anesthesia option for infants
Source: Pain / Anesthetics News From Medical News Today [2015.05.20]
Spinal anesthesia reduces risk of complications during hernia surgeryInfants undergoing some types of surgery could have better recovery if they receive regional anesthesia rather than general...
Local Anesthesia May Be Best for Infants During Surgery
Source: MedicineNet Sleep Specialty [2015.05.15]
Title: Local Anesthesia May Be Best for Infants During Surgery
Category: Health News
Created: 5/14/2015 12:00:00 AM
Last Editorial Review: 5/15/2015 12:00:00 AM
Device created for faster skin biopsies without anesthesia
Source: Dermatology News From Medical News Today [2015.05.08]
Universidad Carlos III de Madrid (UC3M) and the Institute for Health Research of the Hospital "Ramón y Cajal" (IRYCIS have patented a new device for performing skin biopsies.
Surgery Patients Might Not Need Sedative Before Anesthesia
Source: MedicineNet lorazepam Specialty [2015.03.04]
Title: Surgery Patients Might Not Need Sedative Before Anesthesia
Category: Health News
Created: 3/3/2015 12:00:00 AM
Last Editorial Review: 3/4/2015 12:00:00 AM
For children with autism, trips to the dentist just got easier
Source: Autism News From Medical News Today [2015.05.14]
Adjusting the environment to be more soothing could eliminate the need for general anesthesia to cope with routine cleaningsGoing to the dentist might have just gotten a little less scary for the...
Published Studies Related to Nuromax (Doxacurium)
Pharmacokinetics of doxacurium during normothermic and hypothermic cardiopulmonary bypass surgery. [1998.06]
PURPOSE: To compare the pharmacokinetic behaviour of doxacurium in patients undergoing normothermic or hypothermic cardiopulmonary bypass (CPB) for coronary artery bypass graft surgery... CONCLUSION: The elimination rate of doxacurium during normothermic CPB is faster than that in hypothermic CPB.
Neuromuscular effects of doxacurium chloride in isoflurane-anesthetized dogs. [1998.05]
OBJECTIVE: To determine the neuromuscular effects of doxacurium chloride and to construct a dose-response curve for the drug in isoflurane-anesthetized dogs...
Pharmacokinetic-pharmacodynamic modeling of doxacurium: effect of input rate. [1997.02]
One of the basic assumptions in pharmacokinetic-pharmacodynamic modeling (PK-PD) is that drug equilibration rate constant between plasma concentration and effect (Ke0) is not changed by input rate... Our results show that PK-PD parameters derived with either a bolus or an infusion mode of administration are equally reliable.
Doxacurium pharmacodynamics in children during volatile and opioid-based anaesthesia. [1996.04]
The interaction between doxacurium and halothane, isoflurane or alfentanil has not been studied in children. Using the cumulative dose-response technique and electromyography, we determined ED50 and ED90 of doxacurium during halothane (n = 9), isoflurane (n = 12) or alfentanil (n = 9) based anaesthesia in children aged 2-10 years...
Comparison of neuromuscular, cardiovascular, and histamine-releasing properties of doxacurium and pipecuronium. [1996.03]
STUDY OBJECTIVES: To determine the neuromuscular, cardiovascular, and histamine releasing properties of doxacurium and pipecuronium at three times effective ED95 doses (3XFD95)... CONCLUSION: Neither drug caused a clinically significant change in HR or histamine release. In the doses chosen for this study, the rate of onset of block is slower with doxacurium while recovery is more rapid. Histamine release in three patients was caused by thiopental, while in a fourth patient it may have been due to doxacurium.