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Nuromax (Doxacurium Chloride) - Summary

 
 



NUROMAX SUMMARY

NUROMAX®
(doxacurium chloride)
Injection

NUROMAX (doxacurium chloride) is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration. Doxacurium chloride is [1α,2β(1 'S *,2 'R *)]-2,2 ' -[(1,4-dioxo-1,4-butanediyl)bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7,8-trimethoxy-2- methyl-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinolinium] dichloride (meso form).

NUROMAX is a long-acting neuromuscular blocking agent, indicated to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation.


See all Nuromax indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Nuromax (Doxacurium)

Study finds no link between surgical anesthesia and MCI
Source: Pain / Anesthetics News From Medical News Today [2016.01.20]
A Mayo Clinic study of people who received anesthesia for surgery after age 40 found no association between the anesthesia and development of mild cognitive impairment later in life.

Anesthesia After 40 Not Linked to Mental Decline Later, Study Finds
Source: MedicineNet Dementia Specialty [2016.01.20]
Title: Anesthesia After 40 Not Linked to Mental Decline Later, Study Finds
Category: Health News
Created: 1/20/2016 12:00:00 AM
Last Editorial Review: 1/20/2016 12:00:00 AM

More pain before root canal, less to gain from anesthesia
Source: Dentistry News From Medical News Today [2015.12.11]
Before starting any root canal procedure, dental surgeons reach for a local anesthetic.

Who's writing prescriptions for opioid pain relievers?
Source: Medicare / Medicaid / SCHIP News From Medical News Today [2015.12.14]
While prescriptions for opioid pain relievers were concentrated in specialties for pain, anesthesia, and physical medicine and rehabilitation, it was general practitioners who dominated total...

more news >>

Published Studies Related to Nuromax (Doxacurium)

Pharmacokinetics of doxacurium during normothermic and hypothermic cardiopulmonary bypass surgery. [1998.06]
PURPOSE: To compare the pharmacokinetic behaviour of doxacurium in patients undergoing normothermic or hypothermic cardiopulmonary bypass (CPB) for coronary artery bypass graft surgery... CONCLUSION: The elimination rate of doxacurium during normothermic CPB is faster than that in hypothermic CPB.

Neuromuscular effects of doxacurium chloride in isoflurane-anesthetized dogs. [1998.05]
OBJECTIVE: To determine the neuromuscular effects of doxacurium chloride and to construct a dose-response curve for the drug in isoflurane-anesthetized dogs...

Pharmacokinetic-pharmacodynamic modeling of doxacurium: effect of input rate. [1997.02]
One of the basic assumptions in pharmacokinetic-pharmacodynamic modeling (PK-PD) is that drug equilibration rate constant between plasma concentration and effect (Ke0) is not changed by input rate... Our results show that PK-PD parameters derived with either a bolus or an infusion mode of administration are equally reliable.

Doxacurium pharmacodynamics in children during volatile and opioid-based anaesthesia. [1996.04]
The interaction between doxacurium and halothane, isoflurane or alfentanil has not been studied in children. Using the cumulative dose-response technique and electromyography, we determined ED50 and ED90 of doxacurium during halothane (n = 9), isoflurane (n = 12) or alfentanil (n = 9) based anaesthesia in children aged 2-10 years...

Comparison of neuromuscular, cardiovascular, and histamine-releasing properties of doxacurium and pipecuronium. [1996.03]
STUDY OBJECTIVES: To determine the neuromuscular, cardiovascular, and histamine releasing properties of doxacurium and pipecuronium at three times effective ED95 doses (3XFD95)... CONCLUSION: Neither drug caused a clinically significant change in HR or histamine release. In the doses chosen for this study, the rate of onset of block is slower with doxacurium while recovery is more rapid. Histamine release in three patients was caused by thiopental, while in a fourth patient it may have been due to doxacurium.

more studies >>


Page last updated: 2016-01-20

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