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Nuromax (Doxacurium Chloride) - Summary

 
 



NUROMAX SUMMARY

NUROMAX®
(doxacurium chloride)
Injection

NUROMAX (doxacurium chloride) is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration. Doxacurium chloride is [1α,2β(1 'S *,2 'R *)]-2,2 ' -[(1,4-dioxo-1,4-butanediyl)bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7,8-trimethoxy-2- methyl-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinolinium] dichloride (meso form).

NUROMAX is a long-acting neuromuscular blocking agent, indicated to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation.


See all Nuromax indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Nuromax (Doxacurium)

While under general anesthesia rats' brains may 'remember' odor experienced
Source: Pain / Anesthetics News From Medical News Today [2014.03.19]
Rats' brains may remember odors they were exposed to while deeply anesthetized, suggests research in rats published in the April issue of Anesthesiology.

Anesthesia May Harm Children's Brains
Source: MedicineNet Ear Tubes Specialty [2012.08.20]
Title: Anesthesia May Harm Children's Brains
Category: Health News
Created: 8/20/2012 11:00:00 AM
Last Editorial Review: 8/20/2012 12:00:00 AM

A biomarker for postoperative cognitive dysfunction - aspartic acid in the hippocampus:
Source: Pain / Anesthetics News From Medical News Today [2014.04.01]
Postoperative cognitive dysfunction is the deterioration of cognitive performance after anesthesia and surgery, and manifests as impairments in short-term memory, concentration, language...

Comparable outcomes for outpatient, inpatient orthopaedic surgeries
Source: Arthritis / Rheumatology News From Medical News Today [2014.03.15]
As the effectiveness of anesthesia, pain management and rehabilitation continues to improve, more orthopaedic procedures are being done on an outpatient basis.

more news >>

Published Studies Related to Nuromax (Doxacurium)

Pharmacokinetics of doxacurium during normothermic and hypothermic cardiopulmonary bypass surgery. [1998.06]
PURPOSE: To compare the pharmacokinetic behaviour of doxacurium in patients undergoing normothermic or hypothermic cardiopulmonary bypass (CPB) for coronary artery bypass graft surgery... CONCLUSION: The elimination rate of doxacurium during normothermic CPB is faster than that in hypothermic CPB.

Neuromuscular effects of doxacurium chloride in isoflurane-anesthetized dogs. [1998.05]
OBJECTIVE: To determine the neuromuscular effects of doxacurium chloride and to construct a dose-response curve for the drug in isoflurane-anesthetized dogs...

Pharmacokinetic-pharmacodynamic modeling of doxacurium: effect of input rate. [1997.02]
One of the basic assumptions in pharmacokinetic-pharmacodynamic modeling (PK-PD) is that drug equilibration rate constant between plasma concentration and effect (Ke0) is not changed by input rate... Our results show that PK-PD parameters derived with either a bolus or an infusion mode of administration are equally reliable.

Doxacurium pharmacodynamics in children during volatile and opioid-based anaesthesia. [1996.04]
The interaction between doxacurium and halothane, isoflurane or alfentanil has not been studied in children. Using the cumulative dose-response technique and electromyography, we determined ED50 and ED90 of doxacurium during halothane (n = 9), isoflurane (n = 12) or alfentanil (n = 9) based anaesthesia in children aged 2-10 years...

Comparison of neuromuscular, cardiovascular, and histamine-releasing properties of doxacurium and pipecuronium. [1996.03]
STUDY OBJECTIVES: To determine the neuromuscular, cardiovascular, and histamine releasing properties of doxacurium and pipecuronium at three times effective ED95 doses (3XFD95)... CONCLUSION: Neither drug caused a clinically significant change in HR or histamine release. In the doses chosen for this study, the rate of onset of block is slower with doxacurium while recovery is more rapid. Histamine release in three patients was caused by thiopental, while in a fourth patient it may have been due to doxacurium.

more studies >>


Page last updated: 2014-04-01

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