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Nuromax (Doxacurium Chloride) - Summary

 
 



NUROMAX SUMMARY

NUROMAX®
(doxacurium chloride)
Injection

NUROMAX (doxacurium chloride) is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration. Doxacurium chloride is [1α,2β(1 'S *,2 'R *)]-2,2 ' -[(1,4-dioxo-1,4-butanediyl)bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7,8-trimethoxy-2- methyl-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinolinium] dichloride (meso form).

NUROMAX is a long-acting neuromuscular blocking agent, indicated to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation.


See all Nuromax indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Nuromax (Doxacurium)

The Growing Importance of Nonoperating Room Anesthesia Care
Source: Medscape Anesthesiology Headlines [2017.05.17]
Anesthesiologists are increasingly being called upon to provide anesthesia outside the OR, such as in the MRI or endoscopy suite or cath lab. Are guidelines and training lagging behind?
Anesthesia & Analgesia

A Movie Instead of Anesthesia for Kids' Radiation Therapy
Source: MedicineNet Radiation Therapy Specialty [2017.05.09]
Title: A Movie Instead of Anesthesia for Kids' Radiation Therapy
Category: Health News
Created: 5/9/2017 12:00:00 AM
Last Editorial Review: 5/9/2017 12:00:00 AM

Preparing for Anesthesia: 5 Tips You Should Know
Source: MedicineNet Low Blood Pressure Specialty [2017.04.10]
Title: Preparing for Anesthesia: 5 Tips You Should Know
Category: Health News
Created: 4/7/2017 12:00:00 AM
Last Editorial Review: 4/10/2017 12:00:00 AM

Sedation After Cardiac Surgery: Is One Drug Preferable?
Source: Medscape Anesthesiology Headlines [2017.05.19]
This review compares the use of propofol and dexmedetomidine as adjuncts to fast track the recovery of patients undergoing cardiac surgery. What are their respective advantages and disadvantages?
Anesthesia & Analgesia

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Published Studies Related to Nuromax (Doxacurium)

Pharmacokinetics of doxacurium during normothermic and hypothermic cardiopulmonary bypass surgery. [1998.06]
PURPOSE: To compare the pharmacokinetic behaviour of doxacurium in patients undergoing normothermic or hypothermic cardiopulmonary bypass (CPB) for coronary artery bypass graft surgery... CONCLUSION: The elimination rate of doxacurium during normothermic CPB is faster than that in hypothermic CPB.

Neuromuscular effects of doxacurium chloride in isoflurane-anesthetized dogs. [1998.05]
OBJECTIVE: To determine the neuromuscular effects of doxacurium chloride and to construct a dose-response curve for the drug in isoflurane-anesthetized dogs...

Pharmacokinetic-pharmacodynamic modeling of doxacurium: effect of input rate. [1997.02]
One of the basic assumptions in pharmacokinetic-pharmacodynamic modeling (PK-PD) is that drug equilibration rate constant between plasma concentration and effect (Ke0) is not changed by input rate... Our results show that PK-PD parameters derived with either a bolus or an infusion mode of administration are equally reliable.

Doxacurium pharmacodynamics in children during volatile and opioid-based anaesthesia. [1996.04]
The interaction between doxacurium and halothane, isoflurane or alfentanil has not been studied in children. Using the cumulative dose-response technique and electromyography, we determined ED50 and ED90 of doxacurium during halothane (n = 9), isoflurane (n = 12) or alfentanil (n = 9) based anaesthesia in children aged 2-10 years...

Comparison of neuromuscular, cardiovascular, and histamine-releasing properties of doxacurium and pipecuronium. [1996.03]
STUDY OBJECTIVES: To determine the neuromuscular, cardiovascular, and histamine releasing properties of doxacurium and pipecuronium at three times effective ED95 doses (3XFD95)... CONCLUSION: Neither drug caused a clinically significant change in HR or histamine release. In the doses chosen for this study, the rate of onset of block is slower with doxacurium while recovery is more rapid. Histamine release in three patients was caused by thiopental, while in a fourth patient it may have been due to doxacurium.

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Page last updated: 2017-05-19

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