NEWS HIGHLIGHTS
Published Studies Related to Nubain (Nalbuphine)
Combination of opioid agonist and agonist-antagonist: patient-controlled analgesia requirement and adverse events among different-ratio morphine and nalbuphine admixtures for postoperative pain. [2008.10]
BACKGROUND: Nalbuphine, a mixed agonist-antagonist opioid, has a potential to attenuate the mu-opioid effects and to enhance the kappa-opioid effects. However, when morphine and nalbuphine are mixed together, the clinical interactions in different combining ratios on analgesic effect and adverse events are unknown... CONCLUSIONS: The interaction between morphine and nalbuphine in PCA admixture on analgesia is additive. Combinations of morphine and nalbuphine in PCA can decrease the incidence of pruritus, and the antipruritus effect is ratio-dependent. This may provide a novel combination strategy of opioid agonist and agonist-antagonist for postoperative pain management after gynaecologic surgery.
Tramadol versus nalbuphine in total intravenous anaesthesia for dilatation and evacuation. [2007.02]
OBJECTIVE: To compare the results of Tramadol with Nalbuphine for dilatation and evacuation with total intravenous anaesthesia technique... CONCLUSION: Quality of analgesia was better in nalbuphine group but both drugs provide suitable analgesic supplementation to TIVA.
A randomized clinical trial of continuous flow nitrous oxide and nalbuphine infusion for sedation of patients during radiofrequency atrial flutter ablation. [2006.04]
CONCLUSION: Inhalation of a (50% N2O/50% O2) mixture during RF ablation for atrial flutter is a safe and efficient way to reduce anxiety and discomfort caused by RF applications.
Prevention of emergence agitation after sevoflurane anesthesia for pediatric cerebral magnetic resonance imaging by small doses of ketamine or nalbuphine administered just before discontinuing anesthesia. [2006.04]
Magnetic resonance imaging (MRI) requires long-lasting immobilization that frequently can only be provided by general anesthesia in pediatric patients...
Neuroleptics antagonize nalbuphine antianalgesia. [2006.03]
To evaluate the role of sigma receptors in the sexually dimorphic antianalgesic effect of agonist-antagonist kappa opioids, 2 neuroleptics, haloperidol, a sigma receptor antagonist, and chlorpromazine, which has minimal effect at sigma receptors, were administered with the agonist-antagonist kappa opioid nalbuphine in patients with postoperative pain...
Clinical Trials Related to Nubain (Nalbuphine)
Effect of Nalbuphine and Naloxone on Experimentally Induced Skin Sensitivity [Not yet recruiting]
In previous clinical studies of post-surgical pain the investigators found that nalbuphine
(Nubain), a narcotic pain killer, relieves pain more effectively when combined with low-dose
naloxone (Narcan), a drug that is used to treat narcotic overdose. This finding was
particularly true in men. The purpose of this study is to find out if nalbuphine combined
with naloxone is more effective in relieving experimentally produced pain than either drug
alone. A second reason for this study is to find out if study medications work more
effectively in women or in men. Subjects will come to the University of California at San
Francisco (UCSF) Clinical Research Center (CRC) for 4 study visits. The first visit will be
a 2-hour screening to assess the subject for study eligibility. During the other three
visits, the investigators will use a thermal stimulating device to produce temporary,
non-injurious skin sensitivity that subjects will feel as painful. Changes in pain will be
measured following the intravenous (i. v.) administration of study drugs. Three drug
combinations will be administered, a different one each visit: 1) nalbuphine 5 mg and
naloxone 0. 4 mg , 2) naloxone 0. 4 mg and saline (an inactive solution), nalbuphine 5 mg and
saline. These drug combinations will be administered in random order; all subjects will
receive all three combinations.
Nalbuphine for the Treatment of Opioid Induced Pruritus in Children [Active, not recruiting]
Itching is a frequent and disturbing side effect of the use of pain medication such as
morphine. In the post-operative period, it can be more distressing to pediatric patients than
their pain. The current first line treatment, an antihistamine (Benadryl), has a low
efficacy. This treatment causes sleepiness and may be dangerous when used in combination with
other drugs.
Nalbuphine has analgesic properties similar to morphine as well as the ability to reverse
some morphine-induced side effects, such as respiratory depression and itching. Nalbuphine
has been used effectively for patients undergoing Caesarean sections. However, the
effectiveness of nalbuphine in the pediatric population has not been investigated.
We want to determine the efficacy of nalbuphine in the treatment of itching after morphine
for postoperative pain relief. We will use a novel method to measure the effect of the
treatment using an intensity scale before and after the drug, to determine the intensity
difference.
Efficacy of Nalbuphine and Naloxone Administered as Nose Sprays in the Treatment of Orofacial Pain [Recruiting]
Patients with chronic masticatory muscle pain (i. e., pain greater than three months) or
patients with burning mouth syndrome participate in this study. The aim of the study is to
compare the pain killing effectiveness of nalbuphine, a narcotic pain killer, administered
with either placebo or naloxone, a drug used to treat opiate overdose. A second goal is to
determine if there are sex differences in these two drug regimens. Drugs will be
administered with single-use intranasal spray devices. All participants will receive two
sprays (one spray per nostril). One of the two sprays will be nalbuphine (5 mg). The other
spray will be naloxone in half the participants and placebo in the other half.
The Development of Oral Nalbuphine Dosage Form [Recruiting]
Interaction Between Nalbuphine and Morphine in PCA [Recruiting]
1. Nalbuphine is opioid mu receptor antagonist and kappa receptor agonist
2. This study was designed to investigate the interaction between nalbuphine and morphine
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