Novolog Mix 70 / 30 (Insulin Aspart Protamine Suspension / Insulin Aspart Injection) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Clinical trials comparing NovoLog^® Mix 70/30 with Novolin^® 70/30 did not demonstrate a difference in frequency of adverse events between the two treatments.

Adverse events commonly associated with human insulin therapy include the following:

Body as whole: Allergic reactions (see PRECAUTIONS, Allergy).

Skin and Appendages: Local injection site reactions or rash or pruritus, as with other insulin therapies, occurred in 7% of all patients on NovoLog^® Mix 70/30 and 5% on Novolin^® 70/30. Rash led to withdrawal of therapy in <1% of patients on either drug (see PRECAUTIONS, Allergy).

Hypoglycemia: see WARNINGS and PRECAUTIONS.

Other: Small elevations in alkaline phosphatase were observed in patients treated in NovoLog^® controlled clinical trials. There have been no clinical consequences of these laboratory findings.

REPORTS OF SUSPECTED NOVOLOG MIX 70/30 SIDE EFFECTS / ADVERSE REACTIONS

Possible Novolog MIX 70/30 side effects / adverse reactions in 88 year old male

Reported by a individual with unspecified qualification from United States on 2011-10-26

Patient: 88 year old male

Reactions: Blood Glucose Increased

Suspect drug(s):
Colcrys
    Indication: Product Used FOR Unknown Indication

Novolog MIX 70/30
    Indication: Product Used FOR Unknown Indication

Possible Novolog MIX 70/30 side effects / adverse reactions in 85 year old female

Reported by a health professional (non-physician/pharmacist) from Germany on 2011-10-27

Patient: 85 year old female weighing 70.0 kg (154.0 pounds)

Reactions: Syncope, Hypoglycaemia, Drug Interaction

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Actrapid
    Dosage: unk
    Indication: Type 2 Diabetes Mellitus
    Start date: 2009-01-07

Carvedilol
    Dosage: 6.25 mg, bid
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2008-11-07
    End date: 2008-12-14

Enalapril Maleate
    Dosage: 2.5 mg, bid
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2008-11-07
    End date: 2008-12-14

Lantus
    Dosage: 6 iu, qd
    Indication: Type 2 Diabetes Mellitus
    Start date: 2000-01-01

Novolog MIX 70/30
    Dosage: unk
    Indication: Type 2 Diabetes Mellitus
    Start date: 2000-01-01
    End date: 2008-12-14

Repaglinide
    Dosage: 2 mg, tid
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus
    Start date: 2000-01-01
    End date: 2008-12-14

Other drugs received by patient: Allopurinol; Omeprazole; Torsemide; Levothyroxine Sodium; Digitoxin TAB; Spironolactone

Possible Novolog MIX 70/30 side effects / adverse reactions in 76 year old male

Reported by a consumer/non-health professional from France on 2011-11-14

Patient: 76 year old male

Reactions: Dehydration, Hypotension, Hyponatraemia

Adverse event resulted in: hospitalization

Suspect drug(s):
Irbesartan and Hydrochlorothiazide
    Administration route: Oral
    Start date: 2011-09-07

Novolog MIX 70/30
    Start date: 2011-09-06

Other drugs received by patient: Povidone Iodine; Metformin HCL; Trusopt; Insulin Human