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Norvasc (Amlodipine Besylate) - Summary

 
 



NORVASC SUMMARY

Norvasc®
(amlodipine besylate)
Tablets

NORVASC® is the besylate salt of amlodipine, a long-acting calcium channel blocker.

  1. Hypertension
    NORVASC is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
  2. Chronic Stable Angina
    NORVASC is indicated for the treatment of chronic stable angina. NORVASC may be used alone or in combination with other antianginal agents.
  3. Vasospastic Angina (Prinzmetal's or Variant Angina)
    NORVASC is indicated for the treatment of confirmed or suspected vasospastic angina. NORVASC may be used as monotherapy or in combination with other antianginal drugs.


See all Norvasc indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Norvasc (Amlodipine)

Quantification of pedal edema during treatment with S(-)-amlodipine nicotinate versus amlodipine besylate in female Korean patients with mild to moderate hypertension: a 12-week, multicenter, randomized, double-blind, active-controlled, phase IV clinical trial. [2012]
S(-)-amlodipine nicotinate compared with amlodipine besylate... CONCLUSIONS: These female Korean patients with hypertension taking

Comparison of the efficacy and safety of fixed-dose amlodipine/losartan and losartan in hypertensive patients inadequately controlled with losartan: a randomized, double-blind, multicenter study. [2012]
once-daily combination amlodipine/losartan versus losartan... CONCLUSION: Switching to a fixed-dose combination therapy of amlodipine/losartan

Efficacy and safety of aranidipine enteric-coated tablets compared with amlodipine in Chinese patients with mild to moderate essential hypertension: a multicenter, randomized, double-blind, parallel-controlled clinical trial. [2012]
This is a multicenter, randomized, double-blind, parallel-controlled study, conducted in Chinese patients with mild to moderate essential hypertension. After a 2-week washout period, 236 eligible patients were randomly to receive aranidipine 5-10 mg/d (n = 118) or amlodipine 5-10 mg/d (n = 118) for 10 weeks...

Effect of fixed dose combinations of metoprolol and amlodipine in essential hypertension: MARS ? A randomized controlled trial. [2011.12]
Abstract Aim. To compare two strengths of a fixed drug combination (FDC) containing metoprolol XL and amlodipine (metoprolol/amlodipine 50/5; and metoprolol/amlodipine 25/2.5) with its components in hypertension...

Initial combination therapy with amlodipine/valsartan compared with monotherapy in the treatment of hypertension. [2011.09]
Achieving target blood pressure (BP) is influenced by baseline BP. Post hoc analyses of a placebo-controlled trial of amlodipine/valsartan versus monotherapies were conducted to characterize BP control by baseline BP...

more studies >>

Clinical Trials Related to Norvasc (Amlodipine)

Comparing Amlodipine/Atorvastatin Co-Administration To Amlodipine Alone In Patients With Hypertension And Dyslipidemia [Completed]

Aliskiren in Combination With Amlodipine in Hypertensive Patients Not Responding to Angiotensin Receptor Blocker (ARB) Plus Amlodipine [Recruiting]
This study will assess the efficacy and safety of the single pill combination of Aliskiren and Amlodipine in patients with moderate hypertension not adequately responding to a single pill combination of Olmesartan and Amlodipine.

Further this study will also assess the efficacy and safety of a single pill combination of Aliskiren, Amlodipine and Hydrochlorothiazide (HCTZ) in patients with moderate hypertension not adequately responding to a single pill combination of Aliskiren and Amlodipine.

Efficacy/Safety of Valsartan Plus Amlodipine and Amlodipine Alone in Patients With Hypertension [Completed]
This study will evaluate the safety and efficacy of the fixed combination of valsartan/amlodipine in adult patients with mild to moderate hypertension

A Study Comparing the Response of Patients With Hypertension to Amlodipine or Amlodipine Plus Benazepril. [Completed]
Comparison of the safety and efficacy of the combination of amlodipine/Benazepril to amlodipine monotherapy in patients with non-essential hypertension, not controlled on amlodipine alone.

Long Term Study For Amlodipine 10mg With Hypertension For Whom Amlodipine 5mg Is Insufficient [Active, not recruiting]
To investigate the safety and efficacy of the long-term use of amlodipine 10 mg in subjects who will be able to enter a long-term study after completing the parent study "A double-blind comparative study between amlodipine 5 mg and 10 mg in patients with essential hypertension for whom amlodipine 5 mg is insufficiently effective" (Protocol No.: A0531085).

more trials >>

Reports of Suspected Norvasc (Amlodipine) Side Effects

Death (111)Hypertension (93)Malaise (77)Drug Ineffective (75)Dizziness (68)Headache (62)Oedema Peripheral (62)Blood Pressure Increased (58)Cerebrovascular Accident (49)Myocardial Infarction (41)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 15 ratings/reviews, Norvasc has an overall score of 7.27. The effectiveness score is 8 and the side effect score is 7.73. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Norvasc review by 59 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Hypertension
Dosage & duration:   5mg taken once daily for the period of continually
Other conditions:   High cholesterol
Other drugs taken:   Lipitor
  
Reported Results
Benefits:   lowered blood pressure to within normal limits
Side effects:   none that I am aware of
Comments:   took one 5mg tablet daily in the am

 

Norvasc review by 28 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Chest Pain
Dosage & duration:   5mg taken once daily for the period of been taking for 2 months now
Other conditions:   Anxiety/aortic insufficiency
Other drugs taken:   Wellbutrin/Xanax as needed/excedrin migraine
  
Reported Results
Benefits:   I was prescribed Norvasc by my cardiologist because I kept having left sided chest pain. My doctor stated it wasn't angina because i'm so young. I had an echo and stress test which were all normal. each day after taking the pill, i find relief in the chest pain for a while, but then after about an hour it will sometimes come back. I have noticed increase in headaches since taking this med which i went to see a neurologist who wanted me to take neurontin but I refuse to take. He stated the headaches have nothing to do with the heart, but i disagree because when i have this chest pain, the headaches usually are there to, and when the chest pain isn't there, the headache isn't there.
Side effects:   increase in headache.
Comments:   started out the first week with breaking 5mg in half. then after that been taking 5mg daily. B/P was never above 130 systolic and never above 90 diastolic. but was prescibed this because of the intermittent chest pain.

 

Norvasc review by care giver of 93 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   high blood pressure
Dosage & duration:   5 mg taken 1 a day for the period of 2 months
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Lowered blood pressure too much.
Side effects:   Experienced extremely severe rash, swelling and itching over entire body requiring emergency care. New doctor said "I would never prescribe Norvasc to anyone in a million years." Put her back on Lisinapril 10 mg. Rash is dissipating and she is now doing well.
Comments:   93 year old woman with high blood pressure was experiencing skin problems. No other health issues. When switched to Norvasc, problems with skin increased dramatically and rapidly.

See all Norvasc reviews / ratings >>

Page last updated: 2013-02-10

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