Norvasc (Amlodipine Besylate) - Summary

NORVASC SUMMARY

NORVASC^® is the besylate salt of amlodipine, a long-acting calcium channel blocker.

1. Hypertension
   NORVASC is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
2. Chronic Stable Angina
   NORVASC is indicated for the treatment of chronic stable angina. NORVASC may be used alone or in combination with other antianginal agents.
3. Vasospastic Angina (Prinzmetal's or Variant Angina)
   NORVASC is indicated for the treatment of confirmed or suspected vasospastic angina. NORVASC may be used as monotherapy or in combination with other antianginal drugs.

See all Norvasc indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Norvasc (Amlodipine)

Results from a 12 months, randomized, clinical trial comparing an olmesartan/amlodipine single pill combination to olmesartan and amlodipine monotherapies on blood pressure and inflammation. [2014]
profile, insulin sensitivity, and inflammation compared to singles monotherapies... CONCLUSION: Other than to be more effective in reducing blood pressure,

Indirect treatment comparison between fixed-dose-combinations of amlodipine/losartan and amlodipine/valsartan in blood pressure control. [2014]
compared amlodipine/losartan with other FDCs... CONCLUSIONS: The BP lowering effect with amlodipine/losartan and

Effect of levosimendan on the short-term clinical course of patients with acutely decompensated heart failure. [2013]
with acutely decompensated heart failure (ADHF)... CONCLUSIONS: In patients with ADHF, intravenous levosimendan provided rapid and

Comparison of the effects of amlodipine and losartan on blood pressure and diurnal variation in hypertensive stroke patients: a prospective, randomized, double-blind, comparative parallel study. [2013]
variation effects of amlodipine and losartan on acute stroke patients... CONCLUSIONS: The noninferiority of amlodipine was not confirmed by the

Olmesartan/amlodipine combination versus olmesartan or amlodipine monotherapies on blood pressure and insulin resistance in a sample of hypertensive patients. [2013]
Despite the wide range of antihypertensive medications, about 45.5% of treated patients fail to achieve the desired blood pressure (BP) target...

more studies >>

Clinical Trials Related to Norvasc (Amlodipine)

CKD-330 Drug-Drug Interaction Study (Amlodipine) [Completed]
The purpose of this study is to evaluate a pharmacokinetic drug interaction and safety of Amlodipine between free combination of Amlodipine and Candesartan and Amlodipine monotherapy.

A Relative Bioavailability Study of Amlodipine Besylate 10 mg Tablets Tablets Under Fed Conditions [Completed]

A Relative Bioavailability Study of Amlodipine Besylate 10 mg Tablets Under Fasting Conditions [Completed]

Aliskiren and the Calcium Channel Blocker Amlodipine Combination as an Initial Treatment Strategy for Hypertension [Completed]
This study will compare the safety and efficacy of initial combination treatment with aliskiren + amlodipine to sequential add-on treatment strategies with aliskiren or amlodipine in patients with hypertension.

Study to Evaluate the Efficacy and Safety of Aliskiren Alone and in Combination With Amlodipine in Essential Hypertension [Completed]
Evaluate the efficacy (blood pressure lowering effect) and safety of aliskiren alone and in combination with amlodipine in patients with essential hypertension.

more trials >>

Reports of Suspected Norvasc (Amlodipine) Side Effects

Death (111),  Hypertension (93),  Malaise (77),  Drug Ineffective (75),  Dizziness (68),  Headache (62),  Oedema Peripheral (62),  Blood Pressure Increased (58),  Cerebrovascular Accident (49),  Myocardial Infarction (41), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Norvasc review by 59 year old male patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		Hypertension
Dosage & duration:		5mg taken once daily for the period of continually
Other conditions:		High cholesterol
Other drugs taken:		Lipitor
		Reported Results
Benefits:		lowered blood pressure to within normal limits
Side effects:		none that I am aware of
Comments:		took one 5mg tablet daily in the am

Norvasc review by 28 year old male patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Chest Pain
Dosage & duration:		5mg taken once daily for the period of been taking for 2 months now
Other conditions:		Anxiety/aortic insufficiency
Other drugs taken:		Wellbutrin/Xanax as needed/excedrin migraine
		Reported Results
Benefits:		I was prescribed Norvasc by my cardiologist because I kept having left sided chest pain. My doctor stated it wasn't angina because i'm so young. I had an echo and stress test which were all normal. each day after taking the pill, i find relief in the chest pain for a while, but then after about an hour it will sometimes come back. I have noticed increase in headaches since taking this med which i went to see a neurologist who wanted me to take neurontin but I refuse to take. He stated the headaches have nothing to do with the heart, but i disagree because when i have this chest pain, the headaches usually are there to, and when the chest pain isn't there, the headache isn't there.
Side effects:		increase in headache.
Comments:		started out the first week with breaking 5mg in half. then after that been taking 5mg daily. B/P was never above 130 systolic and never above 90 diastolic. but was prescibed this because of the intermittent chest pain.

Norvasc review by care giver of 93 year old female patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		Extremely Severe Side Effects
		Treatment Info
Condition / reason:		high blood pressure
Dosage & duration:		5 mg taken 1 a day for the period of 2 months
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		Lowered blood pressure too much.
Side effects:		Experienced extremely severe rash, swelling and itching over entire body requiring emergency care. New doctor said "I would never prescribe Norvasc to anyone in a million years." Put her back on Lisinapril 10 mg. Rash is dissipating and she is now doing well.
Comments:		93 year old woman with high blood pressure was experiencing skin problems. No other health issues. When switched to Norvasc, problems with skin increased dramatically and rapidly.