Suicidality and Antidepressant Drugs
Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of NORPRAMIN or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. NORPRAMIN is not approved for use in pediatric patients. (See WARNINGS: Clinical Worsening and Suicide Risk, PRECAUTIONS: Information for Patients, and PRECAUTIONS: Pediatric Use.)
|
| |
NORPRAMIN SUMMARY
NORPRAMIN® (desipramine hydrochloride USP) is an antidepressant drug of the tricyclic type.
NORPRAMIN (desipramine hydrochloride) is indicated for the treatment of depression.
|
NEWS HIGHLIGHTSMedia Articles Related to Norpramin (Desipramine)
Depression As Deadly As Smoking, But Anxiety May Be Good For You
Source: Anxiety / Stress News From Medical News Today [2009.11.19]
A study by researchers at the University of Bergen, Norway, and the Institute of Psychiatry (IoP) at King's College London has found that depression is as much of a risk factor for mortality as smoking.
At-Risk College Students Reduce HBP, Anxiety, Depression Through Transcendental Meditation
Source: Anxiety / Stress News From Medical News Today [2009.11.18]
The Transcendental Meditation technique may be an effective method to reduce blood pressure, anxiety, depression, and anger among at-risk college students, according to a new study to be published in the American Journal of Hypertension, December 2009.
Symptoms Of Depression Improved By Motivational "Women-Only" Cardiac Rehab
Source: Depression News From Medical News Today [2009.11.18]
Depressive symptoms improved among women with coronary heart disease who participated in a motivationally-enhanced cardiac rehabilitation program exclusively for women, according to research presented at the American Heart Association's Scientific Sessions 2009. Depression often co-occurs with heart disease and is found more often in women with heart disease than in men.
Telephone-Delivered Care For Treating Depression After CABG Surgery Appears To Improve Outcomes
Source: Depression News From Medical News Today [2009.11.17]
Patients who received telephone-delivered collaborative care for treatment of depression after coronary artery bypass graft surgery reported greater improvement in measures of quality of life, physical functioning and mood than patients who received usual care, according to a study in the November 18 issue of JAMA. The study is being released early online because of its presentation at an American Heart Association scientific conference.
Treating depression after surgery speeds recovery (Reuters)
Source: Y! Health Depression News [2009.11.17]
Reuters - A simple telephone intervention improved mood, physical functioning, and overall quality of life in patients who were depressed after heart bypass surgery, researchers reported in a late breaking clinical trial here at the American Heart Association Scientific Sessions 2009.
Published Studies Related to Norpramin (Desipramine)
A double-blind, multicenter, parallel-group study of paroxetine, desipramine, or placebo in breast cancer patients (stages I, II, III, and IV) with major depression. [2006.02]
CONCLUSION: The small number of women in this study most likely contributed to the lack of observed differences in efficacy observed during the 6 weeks of treatment. Randomized, placebo-controlled trials of adequate power seeking to determine efficacy of antidepressants in the United States for the treatment of women with breast cancer and comorbid depression remain of paramount importance.
Desipramine treatment of cocaine-dependent patients with depression: a placebo-controlled trial. [2005.11.01]
CONCLUSIONS: Desipramine was an effective treatment for depression among cocaine-dependent patients. Improvement in mood was associated with improvement in cocaine abuse, but a direct effect of medication on cocaine outcome was not clearly established and rates of sustained abstinence were low. Future research should examine newer antidepressant medications with more benign side effect profiles and combinations of behavioral and pharmacological treatments to maximize effects on cocaine use.
Comparative effects of duloxetine and desipramine on sleep EEG in healthy subjects. [2005.02]
RATIONALE: Antidepressants are known to modify human sleep patterns.OBJECTIVES: Duloxetine is a new antidepressant with a mechanism of action involving reuptake inhibition of both serotonin (5-HT) and norepinephrine (NE). In this study, the effects of two dosing regimens of duloxetine on sleep electroencephalography (EEG) were investigated at steady-state plasma concentrations in young, healthy, male subjects... CONCLUSIONS: The two dose regimens of duloxetine (80 mg QD and 60 mg BID) produced a REM sleep pattern comparable to that of most antidepressant medications. Duloxetine 80 mg QD appeared to exhibit less impact upon sleep quality than duloxetine 60 mg BID in healthy subjects.
Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response. [2005.01]
The prognostic importance of baseline urines for cocaine was examined in a randomized, placebo-controlled, twelve-week clinical trial in 165 opioid- and cocaine-dependent patients who were treated with desipramine (DMI) in combination with buprenorphine (BUP) or methadone (Meth)... This DMI effect was significant in patients maintained on BUP but not on Meth.
Effects of desipramine and escitalopram on postprandial symptoms induced by the nutrient drink test in healthy volunteers: a randomized, double-blind, placebo-controlled study. [2005]
BACKGROUND: Antidepressants are widely used to treat functional gastrointestinal disorders but their effect on postprandial symptoms remains unstudied. We hypothesized that desipramine and escitalopram would enhance the maximum tolerated volume of nutrient ingested and decrease postprandial symptoms... CONCLUSIONS: While this study does not rule out a beneficial effect of tricyclics or selective serotonin reuptake inhibitors in functional dyspepsia, neither desipramine nor escitalopram significantly altered the nutrient volume ingested or symptoms induced by the nutrient drink test in healthy volunteers. Copyright (c) 2005 S. Karger AG, Basel.
Clinical Trials Related to Norpramin (Desipramine)
Study Evaluating the Pharmacokinetics of the Potential Drug Interaction Between HCV-796 and Desipramine [Completed]
To evaluate the potential pharmacokinetic (PK) interaction of multiple oral doses of HCV-796
and a single dose of desipramine when coadministered to healthy subjects.
Vulvar Vestibulitis Clinical Trial: Desipramine-Lidocaine [Completed]
The Vulvar Vestibulitis Clinical Trial (VVCT) a randomized, placebo-controlled, double
blinded clinical trial. We will study the clinical efficacy of four medical treatments for
vulvar vestibulitis: topical lidocaine, oral desipramine, combined lidocaine and
desipramine, and placebo cream and capsules. Desipramine is a tricyclic antidepressant
commonly used by clinicians for treatment of several chronic pain conditions that
demonstrates an optimal side effect profile compared to other tricyclic antidepressants.
Topical lidocaine has also been found to be beneficial for vulvar vestibulitis treatment in
small studies. It is hypothesized that the combined use of oral desipramine and topical
lidocaine will be more therapeutically effective than either one by itself and better than
placebo.
Pilot Study of the Effects of the Desipramine on the Neurovegetative Parameters of the Child With Rett Syndrome [Recruiting]
Rett syndrome is a neurodevelopmental disorder characterized by cognitive impairment,
communication dysfunction, stereotypic movement disorder, and growth failure. Rett syndrome
is caused by mutations in the Methyl CpG-Binding Protein-2 (MECP2) gene and has no
treatment.
A mouse experimental model of Rett syndrome created by genetic invalidation of the MECP2
gene is available. It had been then observed that adult MECP2-deficient mice show
respiratory alterations and found that endogenous noradrenaline helps to maintain a normal
respiratory rhythm. Desipramine, a selective inhibitor of norepinephrine reuptake, seems to
be efficient to reduce the respiratory alteration occuring in MECP2-deficient mice (Insem
patent 2005, Villard and Roux 2006).
The aim of the study is to evaluate these obtained results in MECP2-deficient mice on
patients with Rett syndrome.
Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine [Recruiting]
Individuals with irritable bowel syndrome (IBS) may experience abdominal pain as a result of
pain signals in the bowel and how these signals are processed in the brain. Studies using
brain imaging (pictures) have shown that IBS patients with more pain diagnoses (i. e.
fibromyalgia, migraines, etc.) have greater activity in the regions of the brain responsible
for the emotional and thought processing of pain signals. This could possibly make bowel
sensations and bowel difficulties feel abnormal or more noticeable, in turn causing more
severe IBS symptoms. The purpose of this protocol is to explore the role of pain diagnoses
and their affect on brain activity in IBS patients. The investigators will also examine the
use of a medication, desipramine, which is known to affect these brain regions, in IBS
patients.
Study Evaluating the Effects of DVS SR and Duloxetine on the Pharmacokinetics of Desipramine in Healthy Subjects [Completed]
|
PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Norpramin has an overall score of 6. The effectiveness score is 6 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
| | Norpramin review by 44 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | migraine |
| Dosage & duration: | | 50 mg taken 1 time per day for the period of 3 years |
| Other conditions: | | migraines |
| Other drugs taken: | | Topamax | | |
Reported Results |
| Benefits: | | no a.m. headaches |
| Side effects: | | mild drowsiness |
| Comments: | | took away morning headaches until I was able to get a better handle on my migraines. |
|
|
|
Page last updated: 2009-11-19
|
