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Noritate (Metronidazole Topical) - Summary



NORITATE ® (metronidazole cream) Cream, 1%, contains metronidazole, USP.

NORITATE is indicated for the topical treatment of inflammatory lesions and erythema of rosacea.

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Published Studies Related to Noritate (Metronidazole Topical)

Controlled study on thymol + eugenol vaginal douche versus econazole in vaginal candidiasis and metronidazole in bacterial vaginosis. [2011]
PURPOSE OF THE STUDY: Bacterial vaginosis (BV) and vaginal candidiasis (VC) are usually managed with topical antibiotics. This study compared the efficacy of a thymol + eugenol vaginal douche (SD) (CAS nr. thymol: 89-83-8 and eugenol: 97-53-0), with econazole (CAS 27220-47-9) in VC and metronidazole (CAS 443-48-1) in BV, as suppository reference therapies. Thymol and eugenol are natural antibacterial and antimycotic active ingredients extracted from plants... CONCLUSION: SD was found to be an effective prescription drug in minor recurrent vaginal infectious episodes and its use can reduce the repeated exposure to antibiotics.

Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease. [2010.09]
BACKGROUND: The potential for metronidazole 10 per cent ointment to exert therapeutic benefit in perianal Crohn's disease, while minimizing the adverse effects found with oral metronidazole, was evaluated in a randomized placebo-controlled study... CONCLUSION: Metronidazole 10 per cent ointment was not effective in the reduction of PDCAI score, but some secondary outcomes showed improvement suggestive of a treatment effect. It is well tolerated, with minimal adverse effects, and has potential as treatment for pain and discharge associated with perianal Crohn's disease. Registration number: NCT00509639 (http://www.clinicaltrials.gov). Copyright 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

Efficacy of topical azelaic acid (AzA) gel 15% plus oral doxycycline 40 mg versus metronidazole gel 1% plus oral doxycycline 40 mg in mild-to-moderate papulopustular rosacea. [2010.06]
Rosacea is a leading reason why people seek the care of a dermatologist, accounting for nearly 7 million office visits annually. Pharmacologic treatments include both topical and oral medications, which are increasingly being used in combination, especially at the outset of therapy... These findings warrant further investigation in a sufficiently powered study.

Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease. [2010]
placebo-controlled study... CONCLUSION: Metronidazole 10 per cent ointment was not effective in the reduction

Innovative use of topical metronidazole. [2010]
Metronidazole is a synthetic nitroimidazole derivative with antimicrobial and antiinflammatory properties. It was the first topical therapy approved solely for rosacea and remains a cornerstone of rosacea management.This article reviews the optimal use of topical metronidazole in the treatment of rosacea and other innovative but off-label dermatologic uses reported in the literature.

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Clinical Trials Related to Noritate (Metronidazole Topical)

A Safety, Tolerability and Pharmacokinetic Study of Two Formulations of Metronidazole Versus Immediate Release Metronidazole in Patient With C. Difficile Colitis [Completed]
Clostridium difficile bacteria can be a cause of significant diarrheal disease, particularly in people who have taken potent antibiotics. When C. difficile multiplies within the colon, it produces two toxins that cause inflammation and resultant abdominal pain, fever and diarrhea. Current treatment of mild to moderate disease is with immediate release metronidazole, an antibiotic that kills C. difficile. Dr. Reddy's Laboratories has developed a delayed release form of metronidazole to release just before the colon to increase the concentration of antibiotic in the colon to improve the effectiveness of metronidazole treatment and potentially to allow less whole body exposure to the antibiotic. This study will measure the amount of metronidazole in the blood and stool of patients with C. difficile associated diarrhea (CDAD) to confirm that the new formulations are releasing the antibiotic as designed, immediately before the colon.

Penicillin and Metronidazole in Treatment of Peritonsillar Abscess [Completed]
Treatment of peritonsillar abscess varies. To study whether broad spectrum antibiotics are required in addition to abscess drainage we perform a prospective, double blind, placebo-controlled, randomised study on 200 adult patients with peritonsillar abscess. 100 patients are given penicillin and metronidazole and 100 patients get penicillin and placebo. Recovery and recurrence and analyzed.

A Study to Assess the Levels of CAZ-AVI and Metronidazole in the Blood When Given Together and Separately [Completed]
The purpose of the study is to assess whether there is any pharmacokinetic interactions between CAZ-AVI and metronidazole.

Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies [Recruiting]
Abnormal vaginal flora is a risk factor for preterm labor. Therefore, in high risk pregnancies for preterm labor the diagnosis and treatment of abnormal flora is indicated. Clindamycin and metronidazole given orally are both acceptable treatments in these cases. The purpose of this study is to compare the effectiveness of Clindamycin Vs metronidazole for the treatment of abnormal vaginal flora in high risk pregnancies. For this purpose, pregnant women who are considered high risk for preterm labor and were diagnosed with abnormal vaginal flora will be randomly treated either with clindamycin or metronidazole. Eradication of the abnormal flora and adverse effects will be monitored and compared

Efficacy of Metronidazole Prophylaxis Against Clostridium Difficile-Associated Diarrhea in High Risk Adult Patients [Recruiting]

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Based on a total of 1 ratings/reviews, Noritate has an overall score of 10. The effectiveness score is 10 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.

Noritate review by 51 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   rash under nasal area
Dosage & duration:   1% cream applied once daily (dosage frequency: daily) for the period of one week
Other conditions:   slight/occasional acne
Other drugs taken:   tetracycline as needed
Reported Results
Benefits:   I had the drug initally offered to me by my dermatologist in sample tube years ago. I found it very effective, despite only dabbing on the smallest amount due to only having small sample tube. Yet despite quick clear-ups...I would occasionally have recurrances under my nose with the rash. I have struggled with this rash for over 20 years. With the last outbreak, while having minimal amounts left in the sample tube, I went in to my dermatologist and got a full prescription in about June of 2009. Not only was I able to use a bit more in application this time, but it obviously was not an expired product. I found the long-term rash hsf completely cleared up within less than a week. While this was not new to me with this product, the fact that I have had no recurrance whatsoever in over four months is the great news.
Side effects:   Absolutely none
Comments:   After washing my face with my long-term personal choice of face wash (Alpha Hydrox foaming face wash) and using a Strident sensitive skin cleaning pad, I would apply the Noritate cream sparingly over the rash under my nose at night. (Note: I did not use the tetracycline during this time, as I knew it was not an acne-related outbreak.)

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Page last updated: 2013-02-10

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