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Nodolor (Isometheptene Mucate / Dichloralphenazone / Acetaminophen) - Description and Clinical Pharmacology

 
 



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DESCRIPTION

Each red capsule contains:
Isometheptene Mucate, USP 65 mg
Dichloralphenazone, USP 100 mg
Acetaminophen, USP 325 mg

Isometheptene Mucate is a white crystalline powder having a characteristic aromatic odor and bitter taste. It is an unsaturated aliphatic amine with sympathomimetic properties. Its molecular weight is 492.65 and it has the following structural formula:

Dichloralphenazone is a white, microcrystalline powder, with slight odor and tastes saline at first, becoming acrid. It is a mild sedative. Its molecular weight is 519.03 and it has the following structural formula:

Acetaminophen, a non-salicylate, occurs as a white, odorless, crystalline powder, possessing a slightly bitter taste. Its molecular weight is 151.16 and it has the following structural formula:

Acetaminophen raises the threshold of painful stimuli, thus exerting an analgesic affect against certain types of headaches.

The inactive ingredients are: Colloidal Silicon Dioxide, FD&C Blue #1, FD&C Red #40, Gelatin, Magnesium Stearate, Microcrystalline Cellulose and Titanium Dioxide.

CLINICAL PHARMACOLOGY

Isometheptene Mucate, a sympathomimetic amine, acts by constricting dilated cranial and cerebral arterioles, thus reducing the stimuli that lead to vascular headaches. Dichloralphenazone, a mild sedative, reduces the patient's emotional reaction to the pain of both vascular and tension headaches. Acetaminophen raises the threshold to painful stimuli, thus exerting an analgesic effect against all types of headaches.

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