NITROLINGUAL SUMMARY
Nitrolingual Pumpspray
Nitroglycerin, an organic nitrate, is a vasodilator which has effects on both arteries and veins. The chemical name for nitroglycerin is 1,2,3-propanetriol trinitrate (C3 H5 N3 O9).
Nitrolingual® Pumpspray is indicated for acute relief of an attack or prophylaxis of angina pectoris due to coronary artery disease.
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NEWS HIGHLIGHTS
Published Studies Related to Nitrolingual (Nitroglycerin Spray)
Short head-up tilt test potentiated with oral nitroglycerine: comparison with a conventional test using isoproterenol. [2004.08]
Conventional tilt test protocols are time consuming and there is no consensus regarding the optimal duration of the test and the provocative drug to be used. This study evaluated the diagnostic power of a short nitroglycerine test against a conventional isoproterenol protocol... For evaluating unexplained syncope the short tilt test protocol with nitroglycerine is less time consuming, easier to perform, and has a higher rate of positive response than a conventional isoproterenol protocol.
Sublingual nitroglycerin versus intravenous ritodrine as tocolytic for external cephalic version: a double-blinded randomized trial. [2003.06]
OBJECTIVE: The purpose of this study was to compare the efficacy of sublingual nitroglycerin with that of intravenous ritodrine as a tocolytic agent for external cephalic version in nulliparous women... CONCLUSION: When compared with intravenous ritodrine, sublingual nitroglycerin was associated with a higher rate of headache, lower blood pressure, and a trend toward a lower rate of successful external cephalic version.
Sublingual nitroglycerine as a tocolytic in external cephalic version: a comparative study. [2003.03]
OBJECTIVE: To study the effect of sublingual nitroglycerine as a tocolytic on the success rate of external cephalic version (ECV) in nulliparous and parous women... CONCLUSION: Although the success rate of ECV has increased in recent years, the use of sublingual nitroglycerine as a tocolytic was not associated with this higher success rate. A randomized, controlled trial is needed.
Methodology of head-up tilt testing potentiated with sublingual nitroglycerin in unexplained syncope. [2000.04.15]
Shortened head-up tilt testing (HUT) potentiated with sublingual nitroglycerin (60 degrees passive standing for 20 minutes followed, if negative, by 400 microg of sublingual nitroglycerin spray with the test continuing for another 20 minutes) differs from conventional nitroglycerin HUT for a shorter drug-free phase (20 vs 45 minutes)...
A randomized crossover evaluation of antianginal efficacy and safety of nitrolingual-spray and nitroglycerin tablet form in coronary artery disease patients. [2000]
Twenty-eight coronary artery disease patients with more than 50% stenosis in at least one major coronary artery completed this randomized crossover clinical trial for the comparison of efficacy and safety of Nitrolingual-Spray and nitroglycerin (NTG) tablets.
Clinical Trials Related to Nitrolingual (Nitroglycerin Spray)
MQX-503 vs Nitroglycerin Ointment: A Pharmacokinetic Comparison in Normal Subjects [Completed]
The purpose of the study is to measure how much nitroglycerin or its metabolites may be found
in the bloodstream when MQX-503 or an FDA approved Nitroglycerin ointment 2% USP is applied
to the skin of healthy subjects.
Blood Pressure Interaction Between Sildenafil and Sublingual Glyceryl Trinitrate (GTN) in Men With Angina [Completed]
The purpose of the study is to determine for how long sildenafil potentiates the blood
pressure reduction that occurs with glyceryl trinitrate in men with angina.
A Study of a Topical Form of Nitroglycerin and Placebo in the Treatment and Prevention of Raynaud's Phenomenon [Active, not recruiting]
The purpose of this research study is to test the safety, tolerability, and effectiveness of
Topical AmphiMatrix with Nitroglycerin (MQX0503) to relieve Raynaud's symptoms and increase
blood flow to the fingers.
Radial Artery Dilation Study: The Effect of Topical Administration of Nitroglycerin and Lidocaine Versus Lidocaine Alone of the Radial Artery Diameter [Recruiting]
The radial artery, which is located on the outer side of the forearm, can be used in
interventional procedures, such as cardiac catheterization, to provide access to the arterial
blood supply. In order to facilitate successful catheterization of the artery, a dilated
artery and one free of arterial spasm is desirable. The proposed study will randomize twenty
three healthy subjects to determine the effect of topical nitroglycerin on radial artery
vasodilation. In the first phase of the study, which is a dose escalation study, each subject
will receive either one or two inches of nitroglycerin in a blinded manner on one wrist and
placebo on the other. Radial artery diameter will be measured with ultrasound at regular
intervals up to two hours. The subjects will then return at a later date at which point they
will receive the alternate dose on one wrist and placebo on the other. In the second phase of
the study, we will randomize the same patients to a mixture of topical nitroglycerin and
lidocaine or topical lidocaine alone. Measurements of radial artery diameter will be
performed as in the first study.
Dose Response to Topical Glyceryl Trinitrate in Patients With Raynaud's Phenomenon [Recruiting]
The purpose of this study is to evaluate the blood flow response to topical Glyceryl
Trinitrate when applied to the skin of patient's fingers with Raynaud's Phenomenon.
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