SUMMARY
NITROGLYCERIN IN 5% DEXTROSE INJECTION
Nitroglycerin is 1,2,3-propanetriol trinitrate, an organic nitrate.
Nitroglycerin in 5% Dextrose Injection is indicated for treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and β-blockers; and for induction of intraoperative hypotension.
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NEWS HIGHLIGHTS
Published Studies Related to Nitroglycerin Injection
Intravenous nitroglycerin for external cephalic version: a randomized controlled trial. [2009.09]
OBJECTIVE: To estimate whether treatment with intravenous nitroglycerin for uterine relaxation increases the chance of successful external cephalic version... CONCLUSION: Treatment with intravenous nitroglycerin increased the rate of successful external cephalic version in nulliparous, but not in multiparous, women. Treatment with intravenous nitroglycerin appeared to be safe, but our numbers were too small to rule out rare serious adverse effects. LEVEL OF EVIDENCE: I.
Optimal starting time of acquisition and feasibility of complementary administration of nitroglycerin with intravenous beta-blocker in multislice computed tomography. [2009.03]
OBJECTIVES: We determined the optimal starting time of acquisition after sublingual nitroglycerin (NTG) administration and evaluated the effects on multislice computed tomographic (MSCT) images of a complementary administration of sublingual NTG with beta-blocker... CONCLUSIONS: It is advisable to obtain MSCT images after sublingual NTG administration because nitrates are always given during conventional CA and may prevent beta-blocker-induced coronary spasm. The optimal starting time for MSCT CA is approximately 3 minutes after sublingual NTG administration.
Intravenous nitroglycerin for prevention of pancreatitis after therapeutic endoscopic retrograde cholangiography: a randomized, double-blind, placebo-controlled multicenter trial. [2008.08]
BACKGROUND AND STUDY AIMS: Several studies have suggested that nitroglycerin promotes pancreatic drainage and thereby helps to prevent pancreatitis occurring after endoscopic retrograde cholangiography (ERC). We performed a multicenter, double-blind, randomized, placebo-controlled trial to evaluate the efficacy of intravenous nitroglycerin for preventing acute pancreatitis in moderate- to high-risk patients undergoing ERC... CONCLUSION: In this study, nitroglycerin offered a limited and clinically nonsignificant benefit for the prevention of post-ERC pancreatitis. Its use did not improve the technical success rate of ERC.
Efficacy of nitroglycerine infusion versus sublingual nifedipine in severe pre-eclampsia: a randomized, triple-blind, controlled trial. [2008.05]
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The effect of intravenous nitroglycerine on blood pressure during intubation. [2008.02]
OBJECTIVES: Hypertension is one of the most frequent complication during laryngoscopy and intubation; thus in the premedication or induction stages, many drugs have been used to control this hypertension. Nitroglycerine is one of the drugs thought to be effective and the purpose of this study is to appraise this deliberation... CONCLUSION: Injection of 2 microg/kg nitroglycerine immediately after anesthetic induction is effective in preventing the unwanted increase in the blood pressure, and as a result, complications following this response in patients with ischemic heart disease would be reduced.
Clinical Trials Related to Nitroglycerin Injection
MQX-503 vs Nitroglycerin Ointment: A Pharmacokinetic Comparison in Normal Subjects [Completed]
The purpose of the study is to measure how much nitroglycerin or its metabolites may be found
in the bloodstream when MQX-503 or an FDA approved Nitroglycerin ointment 2% USP is applied
to the skin of healthy subjects.
A Study of a Topical Form of Nitroglycerin and Placebo in the Treatment and Prevention of Raynaud's Phenomenon [Active, not recruiting]
The purpose of this research study is to test the safety, tolerability, and effectiveness of
Topical AmphiMatrix with Nitroglycerin (MQX0503) to relieve Raynaud's symptoms and increase
blood flow to the fingers.
Blood Pressure Interaction Between Sildenafil and Sublingual Glyceryl Trinitrate (GTN) in Men With Angina [Completed]
The purpose of the study is to determine for how long sildenafil potentiates the blood
pressure reduction that occurs with glyceryl trinitrate in men with angina.
Nitrate and Hypertension in Heart Transplanted Patients [Completed]
The aim of the study was to evaluate the acute effect of nitroglycerine infusion on blood
pressure and heart rate in heart-transplanted patients with cyclosporine-induced
hypertension.
Radial Artery Dilation Study: The Effect of Topical Administration of Nitroglycerin and Lidocaine Versus Lidocaine Alone of the Radial Artery Diameter [Recruiting]
The radial artery, which is located on the outer side of the forearm, can be used in
interventional procedures, such as cardiac catheterization, to provide access to the arterial
blood supply. In order to facilitate successful catheterization of the artery, a dilated
artery and one free of arterial spasm is desirable. The proposed study will randomize twenty
three healthy subjects to determine the effect of topical nitroglycerin on radial artery
vasodilation. In the first phase of the study, which is a dose escalation study, each subject
will receive either one or two inches of nitroglycerin in a blinded manner on one wrist and
placebo on the other. Radial artery diameter will be measured with ultrasound at regular
intervals up to two hours. The subjects will then return at a later date at which point they
will receive the alternate dose on one wrist and placebo on the other. In the second phase of
the study, we will randomize the same patients to a mixture of topical nitroglycerin and
lidocaine or topical lidocaine alone. Measurements of radial artery diameter will be
performed as in the first study.
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