NITRO-TIME SUMMARY
Nitroglycerin is 1,2,3-propanetriol trinitrate, an organic nitrate vasodilator, active on both arteries and veins.
Nitroglycerin Extended-Release Capsules are indicated for the prevention of angina pectoris due to coronary artery disease. The onset of action of oral nitroglycerin is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.
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NEWS HIGHLIGHTS
Published Studies Related to Nitro-Time (Nitroglycerin Extended Release)
N(omega)-nitro-L-arginine methyl ester effects on neutrophil function and bacterial clearance. [2004.08]
Nitric oxide synthase (NOS) inhibitors are considered promising as a therapeutic option in severe septic shock. The aim of this study was to investigate the effects of N-nitro-L-arginine methyl ester (L-NAME) application on neutrophil (PMN) respiratory burst, phagocytosis, and elimination of Escherichia coli from blood and tissue in rabbits.
Pulmonary arterial pressure and electrocardiograms in broiler chickens infused intravenously with L-NAME, an inhibitor of nitric oxide synthase, or sodium nitroprusside (SNP), a nitric oxide donor. [2002.05]
1. Broilers were divided at 42 to 44 d of age into a Control group (n=30) and a Treatment group (n=30).
[Therapy with nitro derivatives and the development of tolerance: a comparative study with stress ECG and dipyridamole ECG] [1999.05]
The ECG stress test represents the most commonly-used technique to evaluate the occurrence of nitroglycerin tolerance. It acts by increasing cardiac O2 demand with resulting insufficient blood flow through a stenotic coronary artery and development of cardiac ischemia... Moreover, the ECG-dipyridamole test showed nitroglycerin tolerance because five patients with a negative acute test (Dip 1) became positive during chronic therapy (Dip 2).
Converting enzyme inhibitors and the role of the sulfhydryl group in the potentiation of exo- and endogenous nitrovasodilators. [1991.09]
In this study, the effect of bradykinin on coronary flow in the isolated rat heart was significantly potentiated when cysteine or the sulfhydryl-containing converting enzyme inhibitors captopril and zofenoprilat were administered simultaneously. In contrast, the effect of concomitant administration of enalaprilat only slightly increased the effect of bradykinin on coronary flow...
Neuroprotective effect of cyclosporine and FK506 against 3-nitropropionic acid induced cognitive dysfunction and glutathione redox in rat: possible role of nitric oxide. [2009.04]
Cyclosporine and FK506, a well-known immunosuppressant drugs that are presently being used for prevention of allograft rejection...
Clinical Trials Related to Nitro-Time (Nitroglycerin Extended Release)
Radial Artery Dilation Study: The Effect of Topical Administration of Nitroglycerin and Lidocaine Versus Lidocaine Alone of the Radial Artery Diameter [Recruiting]
The radial artery, which is located on the outer side of the forearm, can be used in
interventional procedures, such as cardiac catheterization, to provide access to the arterial
blood supply. In order to facilitate successful catheterization of the artery, a dilated
artery and one free of arterial spasm is desirable. The proposed study will randomize twenty
three healthy subjects to determine the effect of topical nitroglycerin on radial artery
vasodilation. In the first phase of the study, which is a dose escalation study, each subject
will receive either one or two inches of nitroglycerin in a blinded manner on one wrist and
placebo on the other. Radial artery diameter will be measured with ultrasound at regular
intervals up to two hours. The subjects will then return at a later date at which point they
will receive the alternate dose on one wrist and placebo on the other. In the second phase of
the study, we will randomize the same patients to a mixture of topical nitroglycerin and
lidocaine or topical lidocaine alone. Measurements of radial artery diameter will be
performed as in the first study.
Dose Response to Topical Glyceryl Trinitrate in Patients With Raynaud's Phenomenon [Recruiting]
The purpose of this study is to evaluate the blood flow response to topical Glyceryl
Trinitrate when applied to the skin of patient's fingers with Raynaud's Phenomenon.
MQX-503 Applied to the Hand Versus Nitroglycerin Ointment Applied to the Chest: A Pharmacokinetic Comparison [Recruiting]
Concurrent Chemotherapy and Radiotherapy With Nitroglycerin in Patients With Locally Advanced Non-Small Cell Lung Cancer [Recruiting]
Nitroglycerin will increase the effectiveness of treatment with induction chemotherapy and
concurrent chemo-radiotherapy by reducing chemo-radio resistance through an increased oxygen
pressure in tumoral tissue. The combination treatment of nitroglycerin and chemotherapy will
result in longer disease-free and over-all survival in patients with locally advanced NSCLC
A Study to Determine the Effect of Nitroglycerin Ointment on the Pain Associated With Chronic Anal Fissures [Recruiting]
Anal fissure is a solitary ulcer in the squamous epithelium of the anus causing intense anal
pain especially upon defecation and for one or two hours afterwards. There are no approved
drugs in the US for this condition and surgery is often the treatment choice. Strakan is
conducting this confirmatory study so the product can be submitted for regulatory approval in
the US. Strakan currently markets this product throughout Europe.
To determine the effect of Cellegesic versus placebo on average pain intensity over every 24
hour period for up to 21 days of treatment in 250 patients.
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