NEWS HIGHLIGHTSMedia Articles Related to Nimotop (Nimodipine)
FDA Nod for Nymalize Nimodipine Oral Solution in SAH
Source: Medscape Nephrology Headlines [2013.05.14]
The FDA has approved the first oral solution of nimodipine, with the aim of reducing fatal medication errors in patients with subarachnoid hemorrhage.
FDA Approvals
Published Studies Related to Nimotop (Nimodipine)
Nimodipine plasma concentration and retinal blood flow in healthy subjects. [2006.08]
PURPOSE: Calcium antagonists are strong vasodilators, and nimodipine is known to improve cerebral blood flow. The purpose of this study was to measure retinal blood flow and nimodipine plasma concentrations during repeated oral dosing... CONCLUSIONS: Oral nimodipine significantly increases retinal perfusion in healthy subjects.
Intravenous magnesium versus nimodipine in the treatment of patients with aneurysmal subarachnoid hemorrhage: a randomized study. [2006.06]
OBJECTIVE: The prophylactic use of nimodipine in patients with aneurysmal subarachnoid hemorrhage reduces the risk of ischemic brain damage. However, its efficacy seems to be rather moderate. The question arises whether other types of calcium antagonists offer better protection. Magnesium, nature's physiological calcium antagonist, is neuroprotective in animal models, promotes dilatation of cerebral arteries, and has an established safety profile. The aim of the current pilot study is to evaluate the efficacy of magnesium versus nimodipine to prevent delayed ischemic deficits after aneurysmal subarachnoid hemorrhage... CONCLUSION: The efficacy of magnesium in preventing delayed ischemic neurological deficits in patients with aneurysmal subarachnoid hemorrhage seems to be comparable with that of nimodipine. The difference in their pharmacological properties makes studies on the combined administration of magnesium and nimodipine seem promising.
Efficacy and safety of nimodipine in subcortical vascular dementia: a randomized placebo-controlled trial. [2005.03]
BACKGROUND AND PURPOSE: Evidence of drug efficacy in vascular dementia (VaD) is scanty. Therapeutic trials should address VaD subtypes. We studied the efficacy and safety of the calcium antagonist nimodipine in subcortical VaD... CONCLUSIONS: Nimodipine may be of some benefit in subcortical VaD. Confirming previous results, the safety analysis of this study shows that in this high-risk population, nimodipine might protect against cardiovascular comorbidities.
Effect of nimodipine on ocular blood flow and colour contrast sensitivity in patients with normal tension glaucoma. [2005.01]
AIM: To investigate the effects of oral nimodipine on ocular haemodynamic parameters and colour contrast sensitivity in patients with normal tension glaucoma (NTG). DESIGN: The study was performed in a randomised, placebo controlled, double masked, crossover design. PARTICIPANTS: Nimodipine (60 mg) or placebo was administered to 14 consecutive NTG patients... CONCLUSIONS: The results indicate that nimodipine increases ONH and choroidal blood flow in NTG patients and improves CCS. The latter effect does not, however, seem to be a direct consequence of the blood flow improvement.
[The effect of intraoperative continuous nimodipine infusion on cerebral vasospasm during intracranial aneurysm surgery] [2004.12.22]
OBJECTIVE: To evaluate the effect of intraoperative continuous nimodipine infusion on cerebral vasospasm during intracranial aneurysm surgery... CONCLUSION: Intraoperative nimodipine infusion may prevent cerebral vasospasm during intracranial aneurysm surgery.
Clinical Trials Related to Nimotop (Nimodipine)
Use of a Calcium Channel Blocker to Prevent Premature Luteinizing Hormone Surges in Infertility Patients [Not yet recruiting]
Nimodipine (Nimotop® Bayer Pharmaceuticals Corporation), unlike other calcium channel
blockers is fat soluble and therefore is able to cross the blood-brain barrier1.
Gonadotropin releasing hormone (GnRH) neurons are clustered in the hypothalamus and are
dependent on calcium flux to release GnRH responsible for the release of
follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.
In a natural menstrual cycle a spontaneous LH surge occurs mid-cycle which triggers
ovulation. The investigators hypothesized that nimodipine, by blocking calcium channels, may
effectively suppress the release of GnRH and consequently the natural LH surge.
In this prospective double-blinded randomized study the investigators will evaluate the
efficacy of nimodipine to inhibit the natural LH surge in women undergoing controlled
ovarian stimulation (COS) and intrauterine insemination (IUI). Nimodipine, if successful,
may represent an inexpensive oral medication as an alternative to the currently used GnRH
agonists or GnRH antagonists in assisted reproductive technologies like IVF.
Nimodipine to Prevent LH Surge During Ovulation Induction: Blinded Placebo-controlled RCT [Recruiting]
The main purpose of this study is to test the effectiveness of nimodipine in preventing a
luteinizing hormone (LH) surge in women undergoing ovulation induction with clomiphene
citrate. It is important to prevent the premature LH surge in controlled ovarian stimulation
to allow adequate recruitment of follicles, proper maturation of a dominant follicle before
ovulation, and effectively time insemination with semen to allow fertilization of a mature
egg to occur.
The investigators are also conducting this study to determine medication side effect profile
(including lightheadedness or dizziness from low blood pressure or rapid heart rate,
headache, and nausea), patient treatment compliance, and clinical pregnancy (positive
pregnancy test and ultrasound evidence of fetal heart rate). Finally, LH and follicle
stimulating hormone (FSH) serum levels will be measured to determine effect of nimodipine on
these hormones.
As a calcium channel blocker, nimodipine has been shown to block calcium mediated release of
gonadotropin releasing hormone in animal and preliminary human studies. The investigators
hypothesize that nimodipine, a calcium channel blocker, will prevent or delay the LH surge
during controlled ovarian stimulation cycles using clomiphene citrate in subfertile patients
undergoing assisted reproduction with intrauterine insemination (IUI).
Effectiveness of Nimodipine Plus Antidepressant Medication in Treating Vascular Depression [Recruiting]
This study will examine whether combined use of an antidepressant medication and the
medication nimodipine reduces risk of depression relapse in patients with vascular
depression.
Randomized, Double-Blind, Placebo-Controlled Trial of Nimodipine for the Neurological Manifestations of HIV-1 [Completed]
PRIMARY: To assess the safety of nimodipine in the treatment of HIV-Associated Motor /
Cognitive Complex (formerly AIDS dementia complex). To assess the systemic or central nervous
system toxicities (e. g., rash, headache, gastrointestinal symptoms, nausea, dyspnea, muscle
pain or cramp, acne) of nimodipine.
SECONDARY: To assess the efficacy of nimodipine in stabilizing the progression of
HIV-Associated Motor / Cognitive Complex by improvement in neuropsychological test
performance, peripheral neuropathy, or other neurologic manifestations.
HIV-infected patients may develop a condition known as HIV-Associated Motor / Cognitive
Complex (also known as AIDS dementia complex) that causes damage to the nervous system,
particularly the brain and spinal cord. Evidence exists that nimodipine protects nerve cells
in culture from injury by HIV. Although nimodipine has been used in patients with other
neurological problems, its safety and effectiveness in halting the progression of
HIV-Associated Motor / Cognitive Complex is not yet known.
High Dose Nimodipine Treatment Adjunct - 1 [Completed]
|
