Media Articles Related to Nilandron (Nilutamide)
Prostate cancer: Astellas announces new enzalutamide data
Source: Clinical Trials / Drug Trials News From Medical News Today [2015.03.26]
Astellas Pharma Europe Ltd. has announced new data from the Phase 2 TERRAIN trial of enzalutamide compared to bicalutamide in metastatic castration-resistant prostate cancer (CRPC), as well as an...
Vitamin D3 May Keep Low-Risk Prostate Cancers in Check
Source: Medscape Today Headlines [2015.03.25]
Vitamin D3. reduced inflammation of the prostate gland after punch biopsy in a small pilot study, and researchers suggest it could keep low-grade cancers from becoming aggressive.
Medscape Medical News
Active Surveillance OK in Intermediate-Risk Prostate Cancer?
Source: Medscape Hematology-Oncology Headlines [2015.03.25]
Dr Gerald Chodak discusses two recent studies that provided support for using active surveillance in certain men with intermediate-risk prostate cancer.
Detecting prostate cancer cells in blood can give an early warning of treatment failure
Source: Blood / Hematology News From Medical News Today [2015.03.25]
A blood test that measures the number of cells shed from prostate tumours into the bloodstream can act as an early warning sign that treatment is not working, a major new study shows.
European experts reveal new survey data that demonstrates a need for increased focus on 'the man behind the prostate cancer'
Source: Prostate / Prostate Cancer News From Medical News Today [2015.03.25]
Astellas Pharma Europe Ltd., in partnership with the Every Moment Matters Steering Committee, today announce results from a new survey of men living with prostate cancer across Europe.
Published Studies Related to Nilandron (Nilutamide)
Long-term efficacy and safety of nilutamide plus castration in advanced prostate cancer, and the significance of early prostate specific antigen normalization. International Anandron Study Group. [1997.07]
PURPOSE: We studied the long-term efficacy and tolerability of nilutamide, a nonsteroidal antiandrogen, combined with orchiectomy in patients with advanced prostate cancer... CONCLUSIONS: With long-term followup of patients with advanced prostate cancer, the combination of nilutamide and orchiectomy has significant benefits in interval to progression and improved survival compared to orchiectomy and placebo.
A randomised trial comparing the safety and efficacy of the Zoladex 10.8-mg depot, administered every 12 weeks, to that of the Zoladex 3.6-mg depot, administered every 4 weeks, in patients with advanced prostate cancer. The Dutch South East Cooperative Urological Group. 
A new longer-acting depot formulation containing 10.8 mg Zoladex administered every 12 weeks was compared to the 3.6-mg Zoladex depot administered every 28 days, in a randomised trial in patients with advanced prostatic carcinoma in which pharmacodynamic efficacy and safety were assessed... This new formulation which is equivalent to three successive 3.6-mg depots will provide a more convenient dosing regime for both patient and doctor in this indication.
Stimulation of erythropoiesis by the non-steroidal anti-androgen nilutamide in men with prostate cancer: evidence for an agonistic effect? [1994.03]
The effects of steroid hormones are pleiotropic. Similarly, non-steroidal oestrogen receptor antagonists such as tamoxifen exert partial agonistic effects with a species- and tissue-specific pattern...
French multicentre trial comparing Casodex (ICI 176,334) monotherapy with castration plus nilutamide in metastatic prostate cancer: a preliminary report. 
This trial compares Casodex (ICI 176,334) monotherapy with the combination of castration (medical or surgical) plus nilutamide. The trial is now closed to entry, 270 patients having been recruited from 32 French centres... In the majority of patients, the effects of gynaecomastia and breast tenderness did not result in withdrawal.
Total androgen blockade with the use of orchiectomy and nilutamide (Anandron) or placebo as treatment of metastatic prostate cancer. Anandron International Study Group. [1993.12.15]
The efficacy of total androgen blockade using orchiectomy and nilutamide was compared with orchiectomy with placebo in a large double-blind clinical trial with 457 patients. The median interval to objective progression was 20.8 months for total androgen blockade and 14.7 months for orchiectomy alone (P = 0.0041)...
Clinical Trials Related to Nilandron (Nilutamide)
Genomic Guided Therapy With Dasatinib or Nilutamide in Metastatic Castration-Resistant Prostate Cancer [Recruiting]
This is a phase II multi-center study to determine the clinical impact of using a
patient-specific genomic expression signature of androgen receptor (AR) activity to
determine therapy for patients with castration-resistant metastatic prostate cancer (CRPC).
After patient eligibility is determined, the genomic signature will be applied to fresh
frozen tissue harvested from a metastatic lesion during image-guided biopsy. After assessing
for androgen receptor activity, the investigators will select patients for either continued
androgen manipulation with nilutamide (high AR activity) or targeted therapy with dasatinib
(low AR activity). Once patients develop a first progression on either arm, patients will
receive combination therapy with dasatinib and nilutamide. The primary aim is to estimate
the median progression free survival in men with CRPC treated according to tumor AR
activity. The investigators hypothesize that by treating men based upon AR activity, median
progression free survival (PFS) will improve from a historical median of 3. 0 months to 6. 0
Vaccine Therapy Plus Sargramostim and Interleukin-2 Compared With Nilutamide Alone in Treating Patients With Prostate Cancer [Active, not recruiting]
RATIONALE: Vaccines made from prostate cancer cells may make the body build an immune
response to kill tumor cells. Colony-stimulating factors such as sargramostim may increase
the number of immune cells found in bone marrow or peripheral blood. Interleukin-2 may
stimulate a person's white blood cells to kill prostate cancer cells. Androgens can stimulate
the growth of prostate cancer cells. Hormone therapy using nilutamide may fight prostate
cancer by reducing the production of androgens. It is not yet known which treatment regimen
is more effective for treating prostate cancer.
PURPOSE: Randomized phase II trial to compare the effectiveness of vaccine therapy plus
sargramostim and interleukin-2 with that of nilutamide alone in treating patients who have
prostate cancer that has not responded to hormone therapy.
Hormone Therapy With or Without Docetaxel And Estramustine in Treating Patients With Prostate Cancer That is Locally Advanced or At High Risk of Relapse [Recruiting]
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as
nilutamide, bicalutamide, flutamide, or cyproterone may stop the adrenal glands from
producing androgens. Drugs used in chemotherapy use different ways to stop tumor cells from
dividing so they stop growing or die. It is not yet known whether hormone therapy is more
effective with or without chemotherapy in treating prostate cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of hormone therapy with or
without docetaxel and estramustine in treating patients who have prostate cancer that is
locally advanced or at high risk of relapse.
Hormone Therapy With or Without Surgery or Radiation Therapy in Treating Patients With Prostate Cancer [Active, not recruiting]
RATIONALE: Hormones can stimulate the growth of prostate cancer cells. Hormone therapy may
fight prostate cancer by reducing the production of androgens. Radiation therapy uses
high-energy x-rays to damage tumor cells. It is not yet known whether hormone therapy plus
surgery is more effective than hormone therapy plus radiation therapy for prostate cancer.
PURPOSE: This randomized phase III trial is studying giving hormone therapy alone to see how
well it works compared to giving hormone therapy together with bilateral orchiectomy or
radiation therapy in treating patients with stage III or stage IV prostate cancer.
Chemotherapy Plus Hormone Therapy Versus Androgen Suppression in Treating Patients With Metastatic or Unresectable Prostate Cancer [Active, not recruiting]
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Combining hormone therapy with chemotherapy and androgen
suppression may kill more tumor cells. It is not yet known which treatment regimen is more
effective for prostate cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of chemotherapy plus hormone
therapy versus androgen suppression alone as initial therapy in patients with prostate cancer
that is metastatic or that cannot be removed surgically.