NEWS HIGHLIGHTSMedia Articles Related to Nicotrol NS (Nicotine Nasal)
Smoking Cessation Program Offers Childhood Cancer Survivors Help To Quit The Habit
Source: Smoking / Quit Smoking News From Medical News Today [2009.11.17]
As smokers nationwide struggle to quit the habit, St. Jude Children's Research Hospital is offering assistance to those childhood cancer survivors who need help with smoking cessation. Despite the known health risks of tobacco use, about 18 percent of adults who survived childhood cancer are smokers-an average almost equal to that of the general population.
American Lung Association Urges Full Coverage Of Clinically Proven Smoking Cessation Treatments
Source: Respiratory / Asthma News From Medical News Today [2009.11.11]
As the debate over health care reform dominates the media and political arena, a new American Lung Association report finds that states aren't doing enough to help smokers quit - and policymakers must fix this in the health care reform process.
Medicaid Smoking Cessation Access on the Rise
Source: MedPage Today Psychiatry [2009.11.06]
Patients in 84% of the nation's Medicaid programs have access to tobacco-dependence treatment, but the availability and extent of coverage varied significantly, researchers found.
Published Studies Related to Nicotrol NS (Nicotine Nasal)
Use of nicotine substitute prescribed at hourly plus ab libitum intake or ad libitum for heavy smokers willing to quit: a randomized controlled trial. [2009.06.02]
OBJECTIVE: To assess the impact of instructional guidance in the regular use of use nicotine nasal spray (NNS) on the true use of NNS during the first three weeks of smoking cessation for heavy smokers who are willing to quit... CONCLUSION: Heavy smokers willing to quit use NNS frequently, regardless of the instructions given. Recommending the use of NNS only when craving appears for heavy smokers willing to quit seems acceptable compared to prescribing hourly administration. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00861276.
Positive effects of nicotine on cognition: the deployment of attention for prospective memory. [2009.01]
RATIONALE: Human and animal studies over the last two decades report that nicotine can improve cognitive performance. Prospective memory (PM), the retrieval and implementation of a previously encoded intention, is also improved by pre-administration of nicotine. As with other nicotine effects, however, predicting precisely how and when nicotine improves the processes engaged by PM has proved less straightforward. OBJECTIVE: We present two studies that explore the source of nicotine's enhancement of PM. Experiment 1 tests for effects of nicotine on preparatory attention (PA) for PM target detection. Experiment 2 asks whether nicotine enhances processing of the perceptual attributes of the PM targets... CONCLUSION: The present study suggests that nicotinic stimulation does not work to enhance perceptual salience of target stimuli (experiment 2), nor does it work through better deployment of preparatory working attention (experiment 1). An alternative explanation that nicotine promotes PM detection by facilitating disengagement from the ongoing task is suggested as a future line of investigation.
A randomized trial of nicotine nasal spray in adolescent smokers. [2008.09]
OBJECTIVES: Nicotine nasal spray has been 1 of the most successful forms of nicotine-replacement therapy in adult populations. The nasal sprayer has not been studied in adolescent smokers. The objective of this pilot study was to determine the feasibility and utility of using nicotine nasal spray for adolescent smokers who wanted to quit smoking... CONCLUSIONS: The unpleasant adverse effects, poor adherence, and consequent lack of efficacy observed in our pilot study do not support the use of nicotine nasal spray as an adjunct to counseling for adolescent smokers who wish to quit.
Transdermal nicotine patch for postoperative pain management: a pilot dose-ranging study. [2008.09]
BACKGROUND: Nicotine has been shown to be antinociceptive in the postoperative period in animal studies. Human studies with nasal nicotine sprays have had mixed results, possibly due to variability in pharmacokinetics and potential patient variables such as exposure to nicotine in tobacco smokers. In this pilot study, we examined the analgesic effect of a transdermal nicotine patch applied before surgery in nonsmokers... CONCLUSIONS: Transdermal nicotine, 5-15 mg, reduced postoperative pain scores but failed to decrease the need for opioid analgesics or opioid-related side effects after general surgical procedures.
Dose-related enhancement of mood and cognition in smokers administered nicotine nasal spray. [2008.02]
The discovery of the role of nicotinic receptors in attention and memory has led to the testing of nicotinic analogs as cognitive enhancing agents in patient populations...
Clinical Trials Related to Nicotrol NS (Nicotine Nasal)
Adjustment of DOses of NIcotine in Smoking Cessation (ADONIS) [Completed]
Nicotine replacement therapies (NRT) have proven efficacy to help smokers quit. However,
their effectiveness is low. This study aims to answer the question: Does the dose adjustment
of NRT according the saliva concentration of nicotine's main metabolite: cotinine improve
their efficacy compared with the lack of dose adjustment (usual care) in smoking patients
with smoking related disease condition.
A Pilot Drug Trial That Evaluates the Whitening Potential of Nicotine Gum [Completed]
The purpose of this research study is to evaluate the effects on existing tooth stain of
nicotine gum. The study will enroll adults who have visible tooth staining.
Bio-Behavioral Predictors of the Efficacy of Nicotine Replacement Therapy (NRT) [Active, not recruiting]
The purpose of this research study is to:
1. compare the effectiveness of a nicotine patch and nicotine nasal spray for smoking
cessation; and
2. identify predictors of response to these alternate forms of nicotine replacement therapy
(NRT).
The ultimate objective is to obtain information necessary to match NRT to those smokers with
the greatest need and likelihood of benefit. The investigators hypothesize that the nicotine
nasal spray (NS) will result in significantly higher abstinence rates than transdermal
nicotine (TN) for the following subgroups of smokers: those with genotypes associated with
less transmission of dopamine or serotonin, or greater metabolism of nicotine; and those with
higher levels of novelty-seeking, depression, and attention deficit symptoms.
Nicotine Treatment of Mild Cognitive Impairment (MCI) [Active, not recruiting]
The purpose of this 12-month study is to determine whether nicotine, administered in the form
of nicotine patches, can improve symptoms of memory loss in some people experiencing mild
memory problems (referred to in this study as "mild cognitive impairment" or MCI).
Transdermal Nicotine Patch to Reduce Nicotine Craving and Withdrawal in Schizophrenics [Active, not recruiting]
Individuals with schizophrenia are three times as likely to smoke cigarettes as individuals
without schizophrenia. While a great deal of research has been focused on smoking cessation
programs for healthy individuals, little attention has been directed towards developing an
effective smoking cessation treatment for schizophrenics. This study will evaluate the
effectiveness of a transdermal nicotine patch at reducing nicotine craving and withdrawal
symptoms in schizophrenic individuals who are heavy smokers.
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