NICARDIPINE HYDROCHLORIDE CAPSULES, 20 MG AND 30 MG
Nicardipine hydrochloride capsules for oral administration each contain 20 mg or 30 mg of nicardipine hydrochloride. Nicardipine hydrochloride is a calcium ion influx inhibitor (slow channel blocker or calcium channel blocker).
I. Stable Angina
Nicardipine hydrochloride capsules are indicated for the management of patients with chronic stable angina (effort-associated angina). They may be used alone or in combination with beta-blockers.
Nicardipine hydrochloride capsules are indicated for the treatment of hypertension. They may be used alone or in combination with other antihypertensive drugs. In administering nicardipine it is important to be aware of the relatively large peak to trough differences in blood pressure effect. (See DOSAGE AND ADMINISTRATION.)
Published Studies Related to Nicardipine
Development of nicardipine prolonged-release implants after clipping for
preventing cerebral vasospasm: from laboratory to clinical trial. 
We have developed a drug delivery system using a vasodilating drug that can be
implanted intracranially at the time of surgery for aneurysm clipping, without
systemic side effects or side effects associated with long-term intrathecal drug
administration.We have performed three studies (a
single-center study with consecutive patients; a single-center, randomized,
double-blind trial; and a multicenter cooperative study) and have proved that
implantation of NPRIs reduces the incidence of cerebral vasospasm and DINDs and
improves clinical outcome after SAH.
CLUE: a randomized comparative effectiveness trial of IV nicardipine versus labetalol use in the emergency department. 
INTRODUCTION: Our purpose was to compare the safety and efficacy of food and drug administration (FDA) recommended dosing of IV nicardipine versus IV labetalol for the management of acute hypertension... CONCLUSIONS: Patients treated with nicardipine are more likely to reach the physician-specified SBP target range within 30 minutes than those treated with labetalol.
Nicardipine vs. saline injection as treatment for Peyronie's disease: a prospective, randomized, single-blind trial. [2010.11]
INTRODUCTION: Various conservative treatments for Peyronie's disease (PD) have been attempted over the years. Intralesional verapamil injection has been tested in prospective randomized studies, but the effect of this treatment seems insufficient. Nicardipine is a calcium antagonist alternative to verapamil and is reportedly more effective in vitro. AIM: The objective of our study was to evaluate the usefulness of intralesional nicardipine injection as a conservative treatment for PD in the transition period of acute and chronic phase... CONCLUSION: Our findings indicate that intralesional nicardipine injection is clinically effective as a conservative treatment for PD in the transition period of acute and chronic phase. (c) 2010 International Society for Sexual Medicine.
Effect of intracoronary nicardipine on cardiac enzymes after elective percutaneous coronary intervention. [2009.06]
BACKGROUND: Elevation in cardiac enzymes after percutaneous coronary intervention (PCI) is common and is associated with adverse clinical outcomes. HYPOTHESIS: Administration of intracoronary nicardipine-a calcium channel blocker will reduce cardiac enzyme levels in patients undergoing elective PCI... CONCLUSIONS: In low-risk patients undergoing elective PCI, intracoronary nicardipine administration did not produce a significant cardioprotective effect in reducing postprocedural cardiac enzymes leakage. Copyright (c) 2009 Wiley Periodicals, Inc.
Effect of nicardipine on renal function after robot-assisted laparoscopic radical prostatectomy. [2009.05]
OBJECTIVES: To investigate the renoprotective effect of nicardipine in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALRP) in a prospective trial. Superior visualization of the increasingly performed RALRP requires pneumoperitoneum and extreme head-down tilt, both of which are associated with a decrease in postoperative renal function. Nicardipine causes preferential dilation of the renal arterioles and attenuates renal dysfunction after cardiac surgery... CONCLUSIONS: Continuous infusion of low-dose nicardipine during RALRP seems to offset the deleterious effects of inevitable pneumoperitoneum and extreme head-down tilt on renal function in preserving the eGFR and attenuating the development of renal insufficiency in the immediate postoperative period.
Clinical Trials Related to Nicardipine
The Effect of Nicardipine on Kidney Function During Orthognathic Surgery Under Hypotensive Anesthesia [Not yet recruiting]
Since nicardipine is known to protect kidney function, nicardipine infusion will result in
better renal parameters measured in this study.
Evaluation of IV Cardene(Nicardipine)and Labetalol Use in the Emergency Department [Recruiting]
A Randomized, Double-Blinded, Placebo-Controlled, Dose-Ranging Study of Cardene® I.V. in Pediatric Subjects With Hypertension [Recruiting]
To define the relationship between Cardene I. V. dose, serum concentrations, and blood
pressure reduction in pediatric subjects with hypertension.
NICardipine Neuroprotection in AortiC Surgery (NICNACS) [Not yet recruiting]
The objective of this study is to discover whether an infusion of nicardipine is able to
reduce the time taken to achieve electrocerebral silence (ECS) during cardiopulmonary bypass
(CPB) for aortic surgery.
By inhibiting cold-induced cerebral vasoconstriction, nicardipine will maintain cerebral
blood flow and allow more rapid cooling of the brain during CPB. This will manifest as a
reduction in the time taken to achieve ECS and also as a reduction in overall CPB time.
Antihypertensive Treatment in Acute Cerebral Hemorrhage [Active, not recruiting]
The purpose of this trial is to evaluate the safety and effectiveness of lowering blood
pressure using nicardipine in persons with acute hypertension associated with intracerebral