NEXIUM I.V. SUMMARY
The active ingredient in NEXIUM® I.V. (esomeprazole sodium) for Injection is (S)-5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1 H -benzimidazole sodium a compound that inhibits gastric acid secretion. Esomeprazole is the S-isomer of omeprazole, which is a mixture of the S- and R- isomers.
NEXIUM I.V. for Injection is indicated for the short-term treatment (up to 10 days) of GERD patients with a history of erosive esophagitis as an alternative to oral therapy in patients when therapy with NEXIUM Delayed-Release Capsules is not possible or appropriate.
When oral therapy is possible or appropriate, intravenous therapy with NEXIUM I.V. for Injection should be discontinued and the therapy should be continued orally.
Published Studies Related to Nexium I.V. (Esomeprazole)
Randomised clinical trial: daily pantoprazole magnesium 40Â mg vs. esomeprazole
40Â mg for gastro-oesophageal reflux disease, assessed by endoscopy and symptoms. 
AIM: To compare the efficacy of pantoprazole-Mg and esomeprazole in GERD... CONCLUSIONS: Pantoprazole-Mg 40Â mg was at least as effective as esomeprazole
[Efficacy and safety of esomeprazole, compared with omeprazole, in maintenance
therapy for reflux esophagitis -a phase III, multicenter, randomized,
double-blind trial-]. [Article in Japanese] 
A multicenter, randomized, double-blind study comparing the efficacy and safety
of esomeprazole 20mg/day (E20) and 10mg/day (E10) with omeprazole 10mg/day (O10)
for maintenance of remission in patients with healed reflux esophagitis (RE). For
RE, at week 24, the estimated Kaplan-Meier recurrence-free rates were 92.0%,
87.5%, and 82.7% in the E20, E10, and O10 groups, respectively...
A combination of esomeprazole and aspirin reduces tissue concentrations of
prostaglandin E(2) in patients with Barrett's esophagus. 
CONCLUSIONS: In combination with esomeprazole, short-term administration of
Esomeprazole Compared With Famotidine in the Prevention of Upper Gastrointestinal Bleeding in Patients With Acute Coronary Syndrome or Myocardial Infarction. [2011.11.22]
CONCLUSIONS:In patients with ACS or STEMI, esomeprazole is superior to famotidine in preventing upper gastrointestinal complications related to aspirin, clopidogrel, and enoxaparin or thrombolytics.Am J Gastroenterol advance online publication, 22 November 2011; doi:10.1038/ajg.2011.385.
Impact of a Fixed-Dose Combination of Naproxen and Esomeprazole Magnesium on Serum Thromboxane B(2) Inhibition by Low-Dose Aspirin Over 5 Days in Healthy Adults: A Phase I, Randomized, Double-Blind, Placebo-Controlled, Noninferiority Trial. [2011.11.09]
Background: Low-dose aspirin (LDA) and nonsteroidal anti-inflammatory drugs (NSAIDs) are often used concomitantly; however, some NSAIDs may interfere with LDA antiplatelet activity. OBJECTIVE: We evaluated the impact of coadministered enteric-coated naproxen 500 mg and immediate-release esomeprazole magnesium 20 mg (fixed-dose combination) on LDA-mediated platelet cyclooxygenase (COX)-1 inhibition... CONCLUSIONS: This pilot investigation suggests that LDA coadministered with naproxen/esomeprazole magnesium is noninferior to LDA alone for platelet COX-1 inhibition, as measured by serum TXB(2) concentration, in healthy volunteers. ClinicalTrials.gov identifier: NCT01094483. Copyright (c) 2011 Elsevier HS Journals, Inc. All rights reserved.
Clinical Trials Related to Nexium I.V. (Esomeprazole)
Nexium Study To Suppress Nausea During Chemotherapy [Terminated]
This study will look at a drug called esomeprazole, the newest PPI, as a way to further
reduce the amount of nausea and vomiting seen in breast cancer patients receiving adriamycin
or epirubicin chemotherapy. Esomeprazole may help protect the gut lining from the stomach
acid and thus lessen the nausea and vomiting. If patients have less stomach sickness, they
may be able to enjoy their daily routines much more while they are getting chemotherapy.
Viokase 16, Viokase16 Plus Nexium and Nexium Alone [Terminated]
Our primary hypothesis is that the addition of Nexium to Viokase 16 will decrease the
chronic abdominal pain in patients with small duct chronic pancreatitis in a superior
fashion compared to Viokase 16 plus placebo or to Nexium alone. A secondary hypothesis would
be an increase in quality of life. Our objective is to elucidate the role of Nexium in the
control of pancreatic pain, quality of life, and narcotic usage alone or when added to
Viokase 16. Our endpoints are the reduction of abdominal pain, decreased pain medication
usage, decreased ER visits and decreased hospital admissions for abdominal pain.
The Effect of Nexium and Probiotics on Insulin Secretion and Cardiovascular Risk Factors in Patients With Type 2 Diabetes [Completed]
Plasm Gastrin Concentrations in Response to Nexium Administration in Healthy Volunteers [Completed]
This dose response study is proposed to explore the extent to which Nexium increases
endogenous gastrin concentrations and to assess whether Nexium treatment may be useful in
the setting of islet cell transplantation for type 1 diabetes to expand islet cells in vivo
Study Comparing the Effects of Esomeprazole Adminstered Orally and Intravenously on Basal and Pentrigastrin-stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD) [Completed]
The purpose of this study is to examine the effects of Nexium at a dose of 40mg administered
orally compared to intravenously on the maximum acid output in subjects with symptoms of
Gastroesophageal reflux disease (GERD).
Page last updated: 2014-12-01