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Nevanac (Nepafenac Ophthalmic) - Summary

 
 



NEVANAC SUMMARY

NEVANAC® (nepafenac ophthalmic suspension) 0.1% is a sterile, topical, nonsteroidal anti-inflammatory (NSAID) prodrug for ophthalmic use. Each mL of NEVANAC® suspension contains 1 mg of nepafenac.

NEVANAC® ophthalmic suspension is indicated for the treatment of pain and inflammation associated with cataract surgery.


See all Nevanac indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Nevanac (Nepafenac Ophthalmic)

Prophylactic nepafenac and ketorolac versus placebo in preventing postoperative macular edema after uneventful phacoemulsification. [2012]
randomized clinical trial... CONCLUSIONS: One month after uneventful phacoemulsification, there was no

Nepafenac 0.1% versus fluorometholone 0.1% for preventing cystoid macular edema after cataract surgery. [2011]
DESIGN: Randomized double-masked single-center clinical trial... CONCLUSION: Nepafenac was more effective than fluorometholone in preventing

Vitreous nonsteroidal antiinflammatory drug concentrations and prostaglandin E2 levels in vitrectomy patients treated with ketorolac 0.4%, bromfenac 0.09%, and nepafenac 0.1%. [2009.10]
PURPOSE: To assess vitreous concentrations of nonsteroidal antiinflammatory drugs (NSAIDs) and prostaglandin E(2) in patients treated with NSAIDs before vitrectomy... CONCLUSION: All three NSAIDs penetrated into the vitreous cavity. Topical therapy with ketorolac may lower preoperative vitreous prostaglandin E(2) levels, which may have a clinical impact on the management of prostaglandin-mediated diseases, including cystoid macular edema.

Effects of topical nepafenac on corneal epithelial healing time and postoperative pain after PRK: a bilateral, prospective, randomized, masked trial. [2008.04]
PURPOSE: To assess the effects of nepafenac on corneal epithelial healing time and pain control compared to placebo in patients undergoing photorefractive keratectomy (PRK) surgery... CONCLUSIONS: Treatment with nepafenac 0.1% significantly reduced postoperative pain immediately following surgery and had no significant adverse effect on time to reepithelialization compared to placebo.

Analgesic and anti-inflammatory effectiveness of nepafenac 0.1% for cataract surgery. [2007.12]
BACKGROUND: To compare nepafenac 0.1% with placebo and ketorolac 0.5% for prevention and treatment of ocular pain and inflammation after cataract surgery... CONCLUSION: The anti-inflammatory efficacy of nepafenac 0.1% is better than that of placebo; it is also more comfortable and at least equal to ketorolac 0.5% in the prevention and treatment of postoperative ocular pain and inflammation.

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Clinical Trials Related to Nevanac (Nepafenac Ophthalmic)

Efficacy Study of Triamcinolone Associated With Nepafenac for Treatment of Diabetic Macular Edema [Active, not recruiting]
Diabetics retinopathy remains the major threat to sight in the working age population in the developed world. Furthermore, it is increasing as a major cause of blindness in other parts of the world, especially developing countries. Diabetic macular edema (DME) is a manifestation of diabetic retinopathy that produces loss of central vision. The triamcinolone intravitreal injection (1-4mg) is indicated to treatment of diabetic macular edema and it is considered an important treatment since it improves the visual acuity of patients with resolution of edema. Nepafenac is a non-steroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop (0. 1% solution). Nepafenac is manufactured by Alcon as Nevanac. It is approved by FDA as well as ANVISA. Pre-clinical studies suggest this medication showed efficacy to treat ocular posterior segment inflammation. The purpose of this study is evaluate the efficacy of intravitreal triamcinolone associated with nepafenac eye drops as treatment of diabetic macular edema.

Nepafenac 0.3% Two Study [Completed]
The purpose of this study was to assess the safety and efficacy of Nepafenac Ophthalmic Suspension, 0. 3% for the prevention and treatment of inflammation (swelling and redness) and pain in the eye after cataract extraction.

Confirmatory Study Nepafenac 0.3% [Completed]
The purpose of this study was to assess the safety and efficacy of an investigational eye drop intended for the prevention and treatment of inflammation (swelling and redness) and pain in the eye after cataract extraction.

Topical Nepafenac as Supplement for Diabetic Macular Edema [Completed]
Diabetic macular edema (DME) is a major cause of visual loss in patients with diabetes mellitus. The standard treatment is with focal/grid laser therapy. Topical nepafenac was used as an adjunct therapy for treatment of DME. The aim of this study is to compare the difference of best corrected visual acuity (BCVA) and central macular thickness (CMT) at 3 months post treatment between combination therapy of laser and topical nepafenac and laser monotherapy in patients with DME.

Clinical Outcomes of Bromday (Bromfenac Ophthalmic Solution) 0.09% QD vs. Nevanac (Nepafenac Ophthalmic Suspension) 0.1% [Completed]
This is a single-center, randomized, investigator-masked, parallel group, and active-comparator controlled study investigating the clinical outcomes for visual acuity and macular thickness after treatment with Bromday (bromfenac ophthalmic solution) 0. 09% QD or Nevanac (nepafenac ophthalmic suspension) 0. 1% TID in subjects who have undergone cataract extraction with posterior chamber intraocular lens implantation.

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Reports of Suspected Nevanac (Nepafenac Ophthalmic) Side Effects

Toxic Anterior Segment Syndrome (70)Medication Error (14)OFF Label USE (12)Endophthalmitis (7)Corneal Opacity (6)Post Procedural Complication (5)Ulcerative Keratitis (5)Post Procedural Infection (4)Wrong Technique in Drug Usage Process (3)Visual Acuity Reduced (3)more >>


Page last updated: 2013-02-10

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