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Neurontin (Gabapentin) - Summary

 
 



NEURONTIN SUMMARY

Neurontin® (gabapentin) Capsules
Neurontin® (gabapentin) Tablets
Neurontin®(gabapentin) Oral Solution

Neurontin® (gabapentin) has anticonvulsant and analgesic action. Neurontin® (gabapentin) Capsules, Neurontin® (gabapentin) Tablets, and Neurontin® (gabapentin) Oral Solution are supplied as imprinted hard shell capsules containing 100 mg, 300 mg, and 400 mg of gabapentin, elliptical film-coated tablets containing 600 mg and 800 mg of gabapentin or an oral solution containing 250 mg/5 mL of gabapentin.

Neurontin® (gabapentin) is indicated for the management of postherpetic neuralgia in adults.

Neurontin® (gabapentin) is indicated as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy. Neurontin is also indicated as adjunctive therapy in the treatment of partial seizures in pediatric patients age 3 - 12 years.


See all Neurontin indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Neurontin (Gabapentin)

Year in Review: Epilepsy
Source: MedPage Today Emergency Medicine [2014.12.18]
(MedPage Today) -- The jury is still out on the value of cannabis for seizures, but evidence backs surgery benefit.

Gov't Commits $6 Million to Research on Epilepsy Deaths
Source: MedPage Today Neurology [2014.12.18]
(MedPage Today) -- "Center Without Walls" to address sudden unexplained epilepsy deaths.

Perampanel-Induced Rash Noted in Young Epilepsy Patient
Source: Medscape NeurologyHeadlines [2014.12.17]
Andrew Wilner discusses the first report of severe rash related to the use of perampanel in a child with drug-resistant epilepsy.
Medscape Neurology

Low-Carb, High-Fat Diets Effective for Adult Epilepsy
Source: Medscape NeurologyHeadlines [2014.12.16]
Variations of low-carbohydrate, high-fat dietary plans reduce seizures at a rate similar to that of antiepileptic drugs.
Medscape Medical News

Curative Surgery Possible in Patients With LGS Epilepsy
Source: Medscape NeurologyHeadlines [2014.12.16]
Once considered ineligible for resective surgery, some patients with Lennox-Gastaut syndrome are becoming seizure-free following this procedure.
Medscape Medical News

more news >>

Published Studies Related to Neurontin (Gabapentin)

The effects of gabapentin on methadone based addiction treatment: a randomized controlled trial. [2013]
Gabapentin is a potentially useful drug in alleviating the hyperexcitatory painful states in the control of opiate dependence in acute detoxification and the stabilization phase. This study aim was to evaluate the effectiveness of gabapentin adds-on methadone therapy on lowering the methadone... This drug leads to relief of withdrawal symptoms and lower methadone consumption.

Rationale and design of a multicenter randomized clinical trial of extended release gabapentin in provoked vestibulodynia and biological correlates of response. [2013]
intercourse pain and summative 24-hour pain... CONCLUSION: We will conduct the first multicenter RCT to confirm efficacy of an

Gabapentin versus chlordiazepoxide for outpatient alcohol detoxification treatment. [2013]
individuals randomized to treatment with gabapentin or chlordiazepoxide... CONCLUSIONS: In ambulatory veterans with symptoms of alcohol withdrawal,

Oral gabapentin premedication for elderly patients undergoing intraocular surgery. [2013]
undergoing cataract surgery... CONCLUSIONS: Hence, premedication with oral gabapentin in these elderly patients

Results of a double-blind, placebo-controlled, fixed-dose assessment of once-daily OROS® hydromorphone ER in patients with moderate to severe pain associated with chronic osteoarthritis. [2013]
moderate to severe pain associated with OA... CONCLUSIONS: OROS hydromorphone ER failed to achieve statistical significance for

more studies >>

Clinical Trials Related to Neurontin (Gabapentin)

The Effectiveness of Gabapentin for Post-operative Pain Following Cesarean Section [Recruiting]
Gabapentin has been very effective at treating pain after knee and hip operations, hysterectomies, and many other types of operations. A previous study at the investigators' hospital found that a single pre-operative dose of 600mg gabapentin produced a significant reduction in pain after caesarean section. However, 19% complained of sedation. The purpose of this study is to see whether a reduced dose of gabapentin will produce a similar improvement in pain scores while avoiding adverse effects such as sedation or dizziness. The objective of this study is to compare the efficacy of a single pre-operative oral dose of gabapentin 300mg, versus 600mg and placebo in women undergoing Cesarean section. The investigators' hypothesis is that gabapentin 300mg will result in decreased pain scores similar to gabapentin 600mg, but with reduced side effects.

Pilot Study Comparing Hypnotherapy and Gabapentin for Hot Flashes. [Recruiting]
Premenopausal women with breast cancer who receive endocrine therapy (e. g. tamoxifen) and/or chemotherapy are at risk for experiencing premature menopause because of their treatment. The resulting symptoms, most notably hot flashes, can cause significant detriment to a patient's quality of life. Treatment for menopausal symptoms with the gold standard of hormone replacement therapy is not done routinely as it is unclear whether it can increase risk of tumor recurrence. In addition, many medical oncologists feel it is contraindicated in this population, especially among women whose breast cancers have estrogen receptors. This has lead to an increased interest in options other than estrogen replacement in the treatment of hot flashes, though most investigations of alternative medications have shown a suboptimal response.

Recent studies have suggested that non-drug treatments using alternative or complementary therapies may be effective. Specifically, hypnosis has been promoted as a means to control hot flashes, though it has not been tested in a randomized fashion. In accordance with the National Cancer Institute's recent initiatives to expand the goals of clinical trials to include symptom management studies, our purpose is to evaluate the role of complementary and alternative therapies for improvement of symptoms in women with breast cancer. Specifically, we plan to evaluate the use of hypnotherapy for the treatment of therapy-induced hot flashes in breast cancer survivors. We intend to recruit 60 women into a pilot feasibility trial comparing hypnotherapy to the drug gabapentin (Neurontin®) for the treatment of therapy-induced hot flashes in eligible women who are receiving care at the Breast Health Center. We have chosen gabapentin based on recent studies showing it may be an effective non-estrogen treatment for this indication.

We will identify patients who are experiencing at least one daily hot flash as a result of the treatment they received for their breast cancer for participation. When enrolled, they will be randomized into either the treatment arm, in which they will receive daily gabapentin, or the experimental arm, in which they will undergo weekly hypnotherapy.

Our study hypothesis is that hypnotherapy will be more effective than gabapentin in the control of hot flashes in this population.

Effectiveness of Gabapentin on Chronic Irritability in Neurologically Impaired Children [Recruiting]
This study is a prospective, randomized, double blind, placebo controlled, crossover clinical trial looking at whether gabapentin can provide symptom relief for chronic irritability in neurologically impaired children. The investigators hypothesize gabapentin ins beneficial and safe for children with chronic irritability that persists despite identification and appropriate management of symptom sources.

Gabapentin Treatment of Benzodiazepine Abuse in Methadone Maintenance Patients [Recruiting]
The aim of this project is to study the use of gabapentin in reducing benzodiazepine abuse in methadone maintenance patients. A second aim is to study the effects of gabapentin on craving, mood, anxiety, and sleep disturbance in methadone maintenance patients abusing benzodiazepines. The proposed protocol is a randomized, double-blind, placebo-controlled pilot outpatient trial of gabapentin in the treatment of benzodiazepine abuse in methadone maintenance patients. All subjects will receive weekly manual-guided psychotherapy directed at achieving abstinence and improving current functioning. The primary outcome measure, benzodiazepine use, will be assessed weekly by a combination of self-report (time line follow-back method) and urine toxicology. Associated psychological symptoms of craving, mood, anxiety, and sleep disturbance, will be assessed by a combination of clinician and self-rated instruments.

The investigators hypothesize that individuals receiving methadone maintenance treatment who are abusing (nonprescribed use) benzodiazepines have difficulty in reducing or discontinuing benzodiazepine use because of the significant anxiety, mood, and sleep disturbance symptoms that accompany reduction in use. Gabapentin, an anticonvulsant which has anxiolytic and sedating properties, may alleviate the symptoms associated with a reduction in benzodiazepine abuse and make the achievement of abstinence more likely when administered in the setting of an active psychotherapy condition.

Gabapentin Enacarbil (GSK1838262) Adult Restless Leg Syndrome Post Marketing Commitment Study [Recruiting]
Gabapentin enacarbil (GEn; GSK1838262; HORIZANT), at a dose of 600 mg/day, is currently approved in the United States for the treatment of adults with moderate-to-severe primary Restless Legs Syndrome (RLS). The aim of this study is to compare the efficacy, tolerability, and safety of GEn at lower doses (450 and 300 mg/day) as well as the already approved dose of 600 mg/day versus placebo for the treatment of subjects with moderate to severe primary RLS. This study is being conducted as a post-marketing commitment (PMC) as a condition of the approval of HORIZANT tablets (NDA 022399).

more trials >>

Reports of Suspected Neurontin (Gabapentin) Side Effects

Drug Ineffective (392)Pain (305)Somnolence (157)Malaise (139)Dizziness (136)Feeling Abnormal (116)Pain in Extremity (115)Depression (102)Headache (99)Fatigue (96)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 38 ratings/reviews, Neurontin has an overall score of 6.03. The effectiveness score is 6.84 and the side effect score is 6.63. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Neurontin review by 45 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   difficulty sleeping because of nervous system prob
Dosage & duration:   500 mg at bedtime taken daily for the period of 6 years
Other conditions:   thyroid disease, allergies
Other drugs taken:   thyroid medication
  
Reported Results
Benefits:   Helped to promote sleep without side effects, hangover or any of the other problems associated with other sleep medications. The sleep difficulty was caused by a horrible reaction to another medication called Celexa, which appeared to sensitize my nervous system even after the Celexa was stopped. Ever since taking the Celexa my nervous system has been exquisitely sensitive, with symptoms such as pain, heart palpitations, restless legs, and other such things that totally interrupted my ability to fall asleep and stay asleep.
Side effects:   None
Comments:   Used 400-500 mg at bedtime.

 

Neurontin review by 53 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Chronic pain (neck and migraines)
Dosage & duration:   300 mg. taken 3 times per day for the period of 2 years
Other conditions:   insomnia
Other drugs taken:   Seroquel, Maxalt, Fosamax
  
Reported Results
Benefits:   The course of treatment reduced the severity and the frequency of the neck pain and migraines by about 50%.
Side effects:   Dizziness and fatigue
Comments:   the dose was started small and raised gradually to monitor side effects. It was only moderately successful and the side effects were quite a challenge. It was used as a standard prophylactic treatmemt against frequent migraines.

 

Neurontin review by 25 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Severe neck pain lasting 8-9 mons
Dosage & duration:   1 every 12 hours (dosage frequency: have taken only one so far!) for the period of one
Other conditions:   Neck pain / severe headaches
Other drugs taken:   n/a
  
Reported Results
Benefits:   Well I just wanted to comment or get some incite on this medication. I was just proscribed this medication yesterday took first one before bed as doctor said and woke up this morning feeling like i had drank a case of beer i stumbled getting up out of bed then i felt like i was dying of thirst was just wondering how normal this was? Oh and i was very sleepy and unable to wake up till nearly noon i started to sober up. I have a 3yr old son that i stay home with so i need to be able to function. when i had spoke to my doctor about the problems i was having i told him that i did not want to be on anything strong i had previously been put on Vicodin, oxy-codone and flexeral i hated it i could not take care of my son i could not function im just trying to find a solution for my pain without being messed up.! See back in October of 2009 i fell backwards into a dresser corner while putting my sons clothes up in welkin closet had two possible fractures and two slipped disks was in a neck brace from oct-feb so please let me know if you have any idea what i can do my insurance will not cover physical therapy unfortunately .....
Side effects:   dizziness , sleepy , dry mouth very thirsty
Comments:   treatment was suppose to be to help control neck pain and headaches

See all Neurontin reviews / ratings >>

Page last updated: 2014-12-18

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