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Neosporin (Neomycin Sulfate / Polymyxin B Sulfate / Bacitracin Zinc Ophthalmic) - Summary



Neosporin Ophthalmic Solution (neomycin and polymyxin B sulfates and gramicidin ophthalmic solution) is a sterile antimicrobial solution for ophthalmic use. Each mL contains: neomycin sulfate equivalent to 1.75 mg neomycin base, polymyxin B sulfate equivalent to 10,000 polymyxin B units, and gramicidin 0.025 mg. The vehicle contains alcohol 0.5%, thimerosal 0.

NEOSPORIN Ophthalmic Solution is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis.

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Clinical Trials Related to Neosporin (Neomycin / Polymyxin B / Bacitracin Ophthalmic)

Surgical Site Infection With 0.05% Chlorhexidine (CHG) Compared to Triple Antibiotic Irrigation [Not yet recruiting]
The investigators intend to perform a prospective randomized study and compare the incidence of surgical wound infection between mastectomy wounds irrigated with triple antibiotic solution (one side) and 0. 05% CHG (opposite side) in patients undergoing bilateral breast reconstruction.

Trial in Cardiac Resynchronization Therapy (CRT): Right Ventricular Apex Versus High Posterior Septum [Active, not recruiting]
In heart failure patients we hypothesised that right ventricular high posterior septum is superior to right ventricular apex in CRT and DDD pacemaker. In two separate trials we prospectively randomized the right ventricular lead placement to find evidence of differences in heart failure symptoms (NYHA-class), 6 minute hall walk and echocardiographic measurements of reverse remodelling and dyssynchrony.

Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum [Recruiting]
Cardiac pacing is the only effective treatment for symptomatic bradycardia. The right ventricular apex (RVA) has become the most frequently used ventricular pacing site. However, RVA pacing has been shown to cause left ventricular (LV) dyssynchrony wich can lead to LV dysfunction and development of heart failure. Recent studies in animals have demonstrated that pacing at the LV septum induces significantly less ventricular dyssynchrony than RVA pacing and is able to improve LV function to a similar degree as biventricular (BiV) pacing. In addition it was shown that a LV septum lead can be placed permanently by driving a lead with extended helix from the RV side through the inter-ventricular septum into the LV endocardial layer. This was shown to be a feasible and safe procedure and lead stability was shown during four months of follow-up in otherwise healthy and active canines. LV septum pacing may therefore be a good treatment alternative in patients with symptomatic bradycardia, as well as patients with an indication for cardiac resynchronization therapy (CRT). The purpose of this study is to translate the findings from preclinical studies to the clinical situation by investigating the feasibility, long-term lead stability and safety of LV septum pacing by transvenous approach through the inter-ventricular septum in patients.

Correlation Between Headaches and Septum and Nasal Mucosa Contact [Recruiting]
Headache is the most common complaint to neurologists. In the 80īs and 90's few papers, with limited number of patients, have proposed the association between nasal septum contact and headache. The International Classification of Headaches Disorders proposed specific diagnostic criteria for this entity. With the major use of CT scans, the contact between nasal mucosa and septum is daily observed in many patients without complaint of headache. The purpose of this study is to determine if there is any correlation between nasal and septum mucosa contact and the prevalence of headache. The investigators hypothesized that no correlation will be found using CT scans in a large series of patients.

Bone Substitute in the Multi Traumatized Nasal Septum Reconstruction [Completed]
The aim of this project is to evaluate the safety and efficacy of the biomaterial made of HAP/TCP (BCP, KasiosŪ), in septoplasties of multi traumatized human nose. The use of this biomaterial will avoid the graft sampling and we expect it to be a good substitute to support the nasal pyramid while favouring the respiratory epithelium regeneration. Thus, that would confirm previous in vitro and in vivo studies.

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Reports of Suspected Neosporin (Neomycin / Polymyxin B / Bacitracin Ophthalmic) Side Effects

OFF Label USE (22)Drug Hypersensitivity (20)Rash (16)Product Quality Issue (9)Hypersensitivity (8)Pruritus (7)NO Adverse Event (7)Skin Exfoliation (6)Urticaria (6)Blister (6)more >>

Page last updated: 2011-07-19

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