NEOSPORIN GU SUMMARY
NEOSPORIN® G.U. Irrigant Sterile
(neomycin sulfate–polymyxin B sulfate solution for irrigation)
NEOSPORIN G. U. Irrigant is a concentrated sterile antibiotic solution to be diluted for urinary bladder irrigation. Neomycin sulfate, an antibiotic of the aminoglycoside group, is the sulfate salt of neomycin B and C produced by Streptomyces fradiae. It has a potency equivalent to not less than 600 µg of neomycin per mg.
NEOSPORIN G.U. Irrigant is indicated for short-term use (up to 10 days) as a continuous irrigant or rinse in the urinary bladder of abacteriuric patients to help prevent bacteriuria and gram-negative rod septicemia associated with the use of indwelling catheters.
Since organisms gain entrance to the bladder by way of, through, and around the catheter, significant bacteriuria is induced by bacterial multiplication in the bladder urine, in the mucoid film often present between catheter and urethra, and in other sites. Urinary tract infection may result from the repeated presence in the urine of large numbers of pathogenic bacteria. The use of closed systems with indwelling catheters has been shown to reduce the risk of infection. A three-way closed catheter system with constant neomycin-polymyxin B bladder rinse is indicated to prevent the development of infection while using indwelling catheters.
If uropathogens are isolated, they should be identified and tested for susceptibility so that appropriate antimicrobial therapy for systemic use can be initiated.
Clinical Trials Related to Neosporin GU (Neomycin / Polymyxin B Irrigation)
Surgical Site Infection With 0.05% Chlorhexidine (CHG) Compared to Triple Antibiotic Irrigation [Not yet recruiting]
The investigators intend to perform a prospective randomized study and compare the incidence
of surgical wound infection between mastectomy wounds irrigated with triple antibiotic
solution (one side) and 0. 05% CHG (opposite side) in patients undergoing bilateral breast
Trial in Cardiac Resynchronization Therapy (CRT): Right Ventricular Apex Versus High Posterior Septum [Active, not recruiting]
In heart failure patients we hypothesised that right ventricular high posterior septum is
superior to right ventricular apex in CRT and DDD pacemaker. In two separate trials we
prospectively randomized the right ventricular lead placement to find evidence of
differences in heart failure symptoms (NYHA-class), 6 minute hall walk and echocardiographic
measurements of reverse remodelling and dyssynchrony.
Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum [Recruiting]
Cardiac pacing is the only effective treatment for symptomatic bradycardia. The right
ventricular apex (RVA) has become the most frequently used ventricular pacing site. However,
RVA pacing has been shown to cause left ventricular (LV) dyssynchrony wich can lead to LV
dysfunction and development of heart failure. Recent studies in animals have demonstrated
that pacing at the LV septum induces significantly less ventricular dyssynchrony than RVA
pacing and is able to improve LV function to a similar degree as biventricular (BiV) pacing.
In addition it was shown that a LV septum lead can be placed permanently by driving a lead
with extended helix from the RV side through the inter-ventricular septum into the LV
endocardial layer. This was shown to be a feasible and safe procedure and lead stability was
shown during four months of follow-up in otherwise healthy and active canines. LV septum
pacing may therefore be a good treatment alternative in patients with symptomatic
bradycardia, as well as patients with an indication for cardiac resynchronization therapy
(CRT). The purpose of this study is to translate the findings from preclinical studies to
the clinical situation by investigating the feasibility, long-term lead stability and safety
of LV septum pacing by transvenous approach through the inter-ventricular septum in
Correlation Between Headaches and Septum and Nasal Mucosa Contact [Recruiting]
Headache is the most common complaint to neurologists. In the 80´s and 90's few papers, with
limited number of patients, have proposed the association between nasal septum contact and
headache. The International Classification of Headaches Disorders proposed specific
diagnostic criteria for this entity.
With the major use of CT scans, the contact between nasal mucosa and septum is daily
observed in many patients without complaint of headache.
The purpose of this study is to determine if there is any correlation between nasal and
septum mucosa contact and the prevalence of headache. The investigators hypothesized that no
correlation will be found using CT scans in a large series of patients.
Bone Substitute in the Multi Traumatized Nasal Septum Reconstruction [Completed]
The aim of this project is to evaluate the safety and efficacy of the biomaterial made of
HAP/TCP (BCP, Kasios®), in septoplasties of multi traumatized human nose. The use of this
biomaterial will avoid the graft sampling and we expect it to be a good substitute to
support the nasal pyramid while favouring the respiratory epithelium regeneration. Thus,
that would confirm previous in vitro and in vivo studies.
Page last updated: 2007-11-01