NEOSPORIN GU SUMMARY
NEOSPORIN® G.U. Irrigant Sterile
(neomycin sulfate–polymyxin B sulfate solution for irrigation)
NEOSPORIN G. U. Irrigant is a concentrated sterile antibiotic solution to be diluted for urinary bladder irrigation. Neomycin sulfate, an antibiotic of the aminoglycoside group, is the sulfate salt of neomycin B and C produced by Streptomyces fradiae. It has a potency equivalent to not less than 600 µg of neomycin per mg.
NEOSPORIN G.U. Irrigant is indicated for short-term use (up to 10 days) as a continuous irrigant or rinse in the urinary bladder of abacteriuric patients to help prevent bacteriuria and gram-negative rod septicemia associated with the use of indwelling catheters.
Since organisms gain entrance to the bladder by way of, through, and around the catheter, significant bacteriuria is induced by bacterial multiplication in the bladder urine, in the mucoid film often present between catheter and urethra, and in other sites. Urinary tract infection may result from the repeated presence in the urine of large numbers of pathogenic bacteria. The use of closed systems with indwelling catheters has been shown to reduce the risk of infection. A three-way closed catheter system with constant neomycin-polymyxin B bladder rinse is indicated to prevent the development of infection while using indwelling catheters.
If uropathogens are isolated, they should be identified and tested for susceptibility so that appropriate antimicrobial therapy for systemic use can be initiated.
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NEWS HIGHLIGHTS
Clinical Trials Related to Neosporin GU (Neomycin / Polymyxin B Irrigation)
Clearance of Nasal Staphylococcus Aureus With Triple Antibiotic Ointment [Recruiting]
Staphylococcus aureus, a bacteria that lives commonly in the anterior nostrils, is seen in
about 30% of healthcare workers. Applying mupirocin ointment, a prescription, to the
nostrils twice daily for 5 days is the current standard of care for treatment to clear this
bacteria. This research study is designed to determine the rate of clearance of this
bacteria in healthcare workers who are carriers when using triple antibiotic ointment
instead of mupirocin ointment.
Tissue Characterization in Teeth Treated With a Regeneration Protocol [Not yet recruiting]
The purpose of the investigators study is to characterize the composition of the hard and
soft tissues present in root canals of teeth previously diagnosed with necrotic pulps and
incomplete root formation and treated with a triple antibiotic regeneration protocol. The
investigators hypothesis is that treatment of teeth with necrotic pulps and immature apices
with triple antibiotic paste will stimulate continued root formation by the deposition of
dentin at the root apices. The primary outcome measure will be histological identification
of mineralized tissue and adherent cells in the apical third of these teeth.
Evaluation of the Middle Turbinate Implant for Affixing the Middle Turbinate to the Nasal Septum [Recruiting]
The purpose of this study is to determine the functional performance of the Middle Turbinate
Implant (MTI). The MTI will be used in all patients requiring endoscopic sinus surgery in
which the Principal Investigator determines clinical relevance.
Rhinogenic Headache Improvement After Nasal Operation [Recruiting]
Objective: To determine the efficacy of surgical correction of intranasal mucosal contact
points in improving quality of life and decreasing medication use in patients with
rhinogenic headaches.
Significance: Chronic, debilitating headaches that resist maximal medical treatment by
various headache specialists are sometimes linked to structural anomalies within the nose
that exert pressure on apposing mucosal surfaces. A number of otolaryngologists have
reported success in alleviating rhinogenic headaches with contact point correction surgery.
This practice is supported by anecdotal reports along with retrospective and observational
studies; however, a prospective study with an appropriate surgical control group has not
been conducted. Because the specific effect of contact point correction has not yet been
differentiated from the placebo effect of surgery itself, many headache specialists are
reluctant to recommend surgical evaluation for their patients. To demonstrate the efficacy
of contact point correction surgery to both the headache and otolaryngology communities -
and thus, to make this treatment option more widely available to rhinogenic headache
sufferers - a randomized controlled trial is needed.
Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste [Not yet recruiting]
The purpose of this study is to determine the treatment outcomes in permanent teeth with
necrotic pulp and immature root development that undergo a regenerative procedure using a
triple antibiotic paste (ciprofloxacin, metronidazole, minocycline) versus a double
antibiotic paste (ciprofloxacin, metronidazole)compared to the commonly used mineral
trioxide aggregate (MTA) apexification treatment.
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