NEOPROFEN SUMMARY
NeoProfen®
(ibuprofen lysine)
Injection
NeoProfen® is a clear sterile preservative-free solution of the l-lysine salt of (±)-ibuprofen which is the active ingredient. (±)-Ibuprofen is a nonsteroidal anti-inflammatory agent (NSAID). L-lysine is used to create a water-soluble drug product salt suitable for intravenous administration. Each mL of NeoProfen contains 17.1 mg of ibuprofen lysine (equivalent to 10 mg of (±)-ibuprofen) in Water for Injection, USP. The pH is adjusted to 7.0 with sodium hydroxide or hydrochloric acid.
NeoProfen is indicated to close a clinically significant patent ductus arteriosus (PDA) in premature infants weighing between 500 and 1500 g, who are no more than 32 weeks gestational age when usual medical management (e.g., fluid restriction, diuretics, respiratory support, etc.) is ineffective. The clinical trial was conducted among infants with an asymptomatic PDA. However, the consequences beyond 8 weeks after treatment have not been evaluated; therefore, treatment should be reserved for infants with clear evidence of a clinically significant PDA.
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NEOPROFEN NEWS HIGHLIGHTS
Media Articles Related to Neoprofen (Ibuprofen)
Giving Ibuprofen Before Paracetamol Shortens Fever In Children
Source: Clinical Trials / Drug Trials News From Medical News Today [2008.09.04]
Kids' Fever Time Cut Using Ibuprofen First
Source: MedicineNet Aches, Pain, Fever Specialty [2008.09.04]
Experts Advise Parents Ibuprofen Is Best To Reduce Fever In Children
Source: Pain / Anesthetics News From Medical News Today [2008.09.03]
Ibuprofen No Better at Reducing Alzheimer's Risk
Source: MedicineNet acetylsalicylic acid Specialty [2008.05.29]
Ibuprofen May Cut Alzheimer's Risk
Source: MedicineNet Cox-2 Inhibitors Specialty [2008.05.06]
Published Studies Related to Neoprofen (Ibuprofen)
Effect on blood pressure of lumiracoxib versus ibuprofen in patients with osteoarthritis and controlled hypertension: a randomized trial. [2008.08]
Cost-effectiveness of advising the use of topical or oral ibuprofen for knee pain; the TOIB study [ISRCTN: 79353052]. [2008.07]
Premedication with pregabalin 75 or 150 mg with ibuprofen to control pain after day-case gynaecological laparoscopic surgery. [2008.06]
Antipyretic effect of ibuprofen in Gabonese children with uncomplicated falciparum malaria: a randomized, double-blind, placebo-controlled trial. [2008.05.26]
Ibuprofen versus acetaminophen for the relief of perineal pain after childbirth: a randomized controlled trial. [2008.03]
Clinical Trials Related to Neoprofen (Ibuprofen)
Comparison of the Efficacy of Topical Ibuprofen to Oral Ibuprofen in Adolescent Athletes [Recruiting]
Analgesic Effect of Ibuprofen, Paracetamol (Acetaminophen), and Paracetamol (Acetaminophen) Plus Codeine on Acute Pain [Recruiting]
Ibuprofen Extended-Release Dental Pain Study [Recruiting]
Oral Versus Rectal Ibuprofen for Fever in Young Children - a Randomized Control Study. [Not yet recruiting]
Feeding During Ibuprofen or Indomethacin Treatment of Preterm Infants [Recruiting]
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