NEOPROFEN SUMMARY
NeoProfen®
(ibuprofen lysine)
Injection
NeoProfen® is a clear sterile preservative-free solution of the l-lysine salt of (±)-ibuprofen which is the active ingredient. (±)-Ibuprofen is a nonsteroidal anti-inflammatory agent (NSAID). L-lysine is used to create a water-soluble drug product salt suitable for intravenous administration. Each mL of NeoProfen contains 17.1 mg of ibuprofen lysine (equivalent to 10 mg of (±)-ibuprofen) in Water for Injection, USP. The pH is adjusted to 7.0 with sodium hydroxide or hydrochloric acid.
NeoProfen is indicated to close a clinically significant patent ductus arteriosus (PDA) in premature infants weighing between 500 and 1500 g, who are no more than 32 weeks gestational age when usual medical management (e.g., fluid restriction, diuretics, respiratory support, etc.) is ineffective. The clinical trial was conducted among infants with an asymptomatic PDA. However, the consequences beyond 8 weeks after treatment have not been evaluated; therefore, treatment should be reserved for infants with clear evidence of a clinically significant PDA.
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NEWS HIGHLIGHTSMedia Articles Related to Neoprofen (Ibuprofen)
What Is Ibuprofen? What Is Ibuprofen Used For?
Source: Headache / Migraine News From Medical News Today [2009.08.19]
Ibuprofen is an NSAID (non-steroidal anti-inflammatory drug) that is commonly used for the relief of symptoms of arthritis, fever, primary dysmenorrhea (menstrual pains), and as an analgesic (a medication given to reduce pain without resulting in loss of consciousness). Ibuprofen also has an antiplatelet effect (protects from blood clots), though less than aspirin.
Ibuprofen Rated Best for Pain of Broken Arms
Source: MedicineNet codeine Specialty [2009.08.18]
Title: Ibuprofen Rated Best for Pain of Broken Arms
Category: Health News
Created: 8/18/2009
Last Editorial Review: 8/18/2009
Caldolor Is First Approved Injected Ibuprofen
Source: MedicineNet Hysterectomy Specialty [2009.06.15]
Title: Caldolor Is First Approved Injected Ibuprofen
Category: Health News
Created: 6/13/2009 7:00:00 AM
Last Editorial Review: 6/15/2009
Published Studies Related to Neoprofen (Ibuprofen)
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain. [2009.10]
STUDY OBJECTIVE: We compare the treatment of pain in children with arm fractures by ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine component)... CONCLUSION: Ibuprofen was at least as effective as acetaminophen with codeine for outpatient analgesia for children with arm fractures. There was no significant difference in analgesic failure or pain scores, but children receiving ibuprofen had better functional outcomes. Children receiving ibuprofen had significantly fewer adverse effects, and both children and parents were more satisfied with ibuprofen. Ibuprofen is preferable to acetaminophen with codeine for outpatient treatment of children with uncomplicated arm fractures.
Ascorbic acid combined with ibuprofen in hypoxic ischemic encephalopathy: a randomized controlled trial. [2009.06]
OBJECTIVE: Free oxygen radicals and proinflammatory cytokines are important causes for brain injury in neonates with hypoxic ischemic encephalopathy (HIE). Our objectives were to test the hypothesis that a combination of antioxidants (ascorbic acid) and anti-inflammatory agents (ibuprofen) can ameliorate the brain injury in HIE and improve neurodevelopmental outcomes when given to term infants immediately after birth... CONCLUSION: Early administration of ascorbic acid and ibuprofen did not affect outcomes in infants with perinatal asphyxia. This study does not explain whether our intervention was not effective in blocking free radicals and inflammatory cytokines, if the dosing and route of administration were inadequate, or if other mediators existed that could have a more powerful role in brain injury during hypoxia-ischemia.
Comparison of the analgesic effect of ibuprofen with mesalamine after discectomy surgery in patients with lumbar disc herniation: a double-blind randomized controlled trial. [2009.05]
BACKGROUND: Pain management is an important component in the postoperative period following discectomy. AIMS: We hypothesized that mesalamine considering its better safety profile, is likely to be a better choice, if it would be as effective as ibuprofen in controlling post-discectomy pain. SETTINGS AND DESIGN: A double-blind randomized controlled trial was performed on patients who underwent lumbar discectomy surgery... CONCLUSIONS: Since both drugs showed almost equal analgesic effect, considering its safety profile mesalamine, seems to be the preferred choice to alleviate post-discectomy surgery pain.
Paracetamol and ibuprofen for the treatment of fever in children: the PITCH randomised controlled trial. [2009.05]
OBJECTIVES: To establish the relative clinical effectiveness and cost-effectiveness of paracetamol plus ibuprofen compared with paracetamol and ibuprofen separately for time without fever, and the relief of fever-associated discomfort in young children who can be managed at home... CONCLUSIONS: Young children who are unwell with fever should be treated with ibuprofen first, but the relative risks (inadvertently exceeding the maximum recommended dose) and benefits (extra 2.5 hours without fever) of using paracetamol plus ibuprofen over 24 hours should be considered. However, if two medicines are used, it is recommended that all dose times are carefully recorded to avoid accidentally exceeding the maximum recommended dose. Manufacturers should consider supplying blank charts for this purpose. Use of both medicines should not be discouraged on the basis of cost to either parents or the NHS. Parents and clinicians should be aware that fever is a relatively short-lived symptom, but may have more serious prognostic implications than the other common symptom presentations of childhood.
A randomized, placebo-controlled, exploratory trial of Ibuprofen and pseudoephedrine in the treatment of primary nocturnal enuresis in children. [2009.05]
This exploratory randomized, double-blind, double-dummy, placebo-controlled trial of 14 days duration conducted in 22 primary care practices in the United States was used to compare the efficacy of ibuprofen and pseudoephedrine, administered alone or in combination, to placebo for the treatment of primary nocturnal enuresis (PNE) in children aged 6 to 11 years...
Clinical Trials Related to Neoprofen (Ibuprofen)
Early Versus Late Use of Ibuprofen for PDA Closure [Recruiting]
The primary objective is to evaluate the PDA closure rate of early vs. late use of Ibuprofen
(Ibu). The investigators believe that early use of Ibu will have a higher PDA closure rate
than later use of Ibu. Early use is defined as medication given before the infant reaches
96 hrs old. Late use is defined as medication given when infant is more than 96 hrs old.
The secondary objective is to measure the stress hormone and metabolic response (plasma
catecholamines, glucose, and lactate) of neonates undergoing Ibu treatment of the PDA. The
investigators believe that early ibuprofen will blunt the stress response greater than later
use.
Comparison of the Efficacy of Topical Ibuprofen to Oral Ibuprofen in Adolescent Athletes [Recruiting]
This study was made to compare the efficacy of topical ibuprofen in gel form with oral
ibuprofen in the treatment of sub-acute soft tissue injuries while comparing the
tolerability of the delivery methods
Effect of Ibuprofen, Paracetamol and Their Combination on Radical Oxygen Species (ROS) Production [Recruiting]
The purpose of this study is to determine whether paracetamol, ibuprofen or their
combination can modify generation of radical oxygen species (ROS) from stimulated
neutrophils.
Analgesic Effect of Ibuprofen, Paracetamol (Acetaminophen), and Paracetamol (Acetaminophen) Plus Codeine on Acute Pain [Recruiting]
The purpose of this placebo controlled clinical trial is to evaluate the dose response
relationship of ibuprofen in doses from 400 mg to 800 mg and paracetamol (acetaminophen)in
doses from 500 mg to 1000 mg compared with paracetamol (acetaminophen)1000 mg plus codeine
60 mg on acute postoperative pain after surgical removal of impacted third molars.
The Efficacy and Safety of Dexibuprofen Syrup [Recruiting]
The purpose of this study is to compare the safety and efficacy of dexibuprofen syrup and
ibuprofen syrup in patients with fever due to common cold.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Neoprofen has an overall score of 10. The effectiveness score is 10 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
| | Neoprofen review by 31 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | headaches, menstrual aches/cramps, fever |
| Dosage & duration: | | depends, between 200-400 mg taken when needed for the period of 3 years off and on |
| Other conditions: | | None |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | THE BEST painkillers ever! Quite low dosage when it comes to the active substance used but it does work perfect. I like the fact that they come in two different dosages 200mg and 400mg. When taking this medicine I think that one should take ones weight and the severity of the condition that one wants to treat. |
| Side effects: | | None that I have experienced. These are supposedly one of the least invasive painkillers on the market. |
| Comments: | | I have used it to take down, fever, headaches, PMS cramps, lumbago, the pain just vanishes. |
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Page last updated: 2009-10-20
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