SUMMARY
Neomycin and polymyxin B sulfates and bacitracin zinc with
hydrocortisone acetate ophthalmic ointment is a sterile antimicrobial and
anti-inflammatory ointment for ophthalmic use.
Neomycin and polymyxin B sulfates and bacitracin zinc with hydrocortisone
acetate ophthalmic ointment is indicated for steroid-responsive inflammatory
ocular conditions for which a corticosteroid is indicated and where bacterial
infection or a risk of bacterial infection exists. Ocular corticosteroids are
indicated in inflammatory conditions of the palpebral and bulbar conjunctiva,
cornea, and anterior segment of the globe where the inherent risk of
corticosteroid use in certain infective conjunctivitides is accepted to obtain a
diminution in edema and inflammation. They are also indicated in chronic
anterior uveitis and corneal injury from chemical, radiation, or thermal burns,
or penetration of foreign bodies. The use of a combination drug with an
anti-infective component is indicated where the risk of infection is high or
where there is an expectation that potentially dangerous numbers of bacteria
will be present in the eye (see
CLINICAL
PHARMACOLOGY: Microbiology). The particular anti-infective drugs in
this product are active against the following common bacterial eye pathogens:
Staphylococcus aureus, streptococci, including Streptococcus pneumoniae, Escherichia coli, Haemophilus
influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas
aeruginosa. The product does not provide adequate coverage against Serratia marcescens.
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NEWS HIGHLIGHTS
Clinical Trials Related to Neomycin and Polymyxin B Sulfates and Bacitracin Zinc with Hydrocortisone (Neomycin / Polymyxin B / Bacitracin / Hydrocortisone Ophthalmic)
Effect of Neomycin on the Pharmacokinetics of Regorafenib [Completed]
Neomycin and Rifaximin Plus Neomycin in Treating Methane Positive Constipation Predominant Irritable Bowel Syndrome [Completed]
In this study the investigators aim to compare the efficacy of neomycin to a combination of
rifaximin and neomycin in the treatment of C-IBS subjects with methane on their breath test.
This study will be conducted in collaboration with Dr. John DiBaise at the Mayo Clinic in
Scottsdale, AZ and Dr. Satish Rao in Georgia Regents University in Augusta, GA.
Eradication of Antibiotic-resistant Bacteria Through Antibiotics and Fecal Bacteriotherapy [Not yet recruiting]
This investigator initiated,international, multicenter open-label, randomized controlled
trial aims to assess whether a 5 day course of oral nonabsorbable antibiotics (colistin
sulfate 2 million IU per os 4x/day and neomycin sulfate 500 mg (salt) per os 4x/day )
followed by fecal microbiota transplantation (administered either via nasogastric
administration or via capsules) is effective at eradicating intestinal carriage of
beta-lactamase producing Enterobacteriaceae (ESBL-E) and carbapenemase producing
Enterobacteriaceae (CPE). compared to no intervention (current standard of care) in adult
non-immunosuppressed patients .
Comparison Between Erythromycin and Neomycin Treatment of Hepatic Encephalopathy [Active, not recruiting]
Comparison between the efficacy of two different antibiotics in patients with overt hepatic
encephalopathy. The study is randomized, controlled and double-blinded.
Efficacy of the Combination Bismuth + Neomycin + Procaine in the Treatment of Recurrent Aphthous Ulceration [Completed]
To evaluate the efficacy of the product Bismu-Jet ® (bismuth tartrate and sodium, neomycin
sulfate and procaine hydrochloride) produced by EMS S / A compared to placebo in reducing
the signs and symptoms resulting from UAR in patients of both sexes, with age over 12 years.
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Page last updated: 2010-05-11
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