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Natrecor (Nesiritide) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

No trials specifically examining potential drug interactions with NATRECOR® were conducted, although many concomitant drugs (including IV nitroglycerin) were used in clinical trials [see Clinical Studies]. No drug interactions were detected except for an increase in symptomatic hypotension in patients receiving afterload reducers or affecting the renin-angiotensin system (i.e., ARBs and/or ACE inhibitors).

The co-administration of NATRECOR® with nitroprusside, milrinone, or IV ACE inhibitors has not been evaluated.

OVERDOSAGE

Overdose with NATRECOR® therapy has been reported and is primarily the result of either a miscalculated NATRECOR® dose or a mechanical error such as an infusion-pump malfunction or an infusion-pump programming error. The most frequently reported adverse event reported with NATRECOR® overdose is hypotension, which may be symptomatic and may persist for several hours. Asymptomatic hypotensive events may resolve with drug stoppage. In some cases hypotension may persist for several hours beyond discontinuation. In the event of an overdose, discontinue NATRECOR® and support blood pressure [see Warnings and Precautions].

CONTRAINDICATIONS

NATRECOR® is contraindicated in patients with:

  • Persistent systolic blood pressure <100 mm Hg prior to therapy because of an increased risk of symptomatic hypotension [see Warnings and Precautions]
  • Known hypersensitivity to any of its components [see Warnings and Precautions]
  • Cardiogenic shock

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