(natamycin ophthalmic suspension)
NATACYN® (natamycin ophthalmic suspension) 5% is a sterile, antifungal drug for topical ophthalmic administration.
NATACYN (natamycin ophthalmic suspension) 5% is indicated for the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis. As in other forms of suppurative keratitis, initial and sustained therapy of fungal keratitis should be determined by the clinical diagnosis, laboratory diagnosis by smear and culture of corneal scrapings and drug response. Whenever possible the in vitro activity of natamycin against the responsible fungus should be determined. The effectiveness of natamycin as a single agent in fungal endophthalmitis has not been established.
Published Studies Related to Natacyn (Natamycin Ophthalmic)
Voriconazole versus natamycin as primary treatment in fungal corneal ulcers. [2011.07]
BACKGROUND: To evaluate the efficacy of topical 1% voriconazole versus 5% natamycin in treatment of fungal corneal ulcers. DESIGN: A prospective, randomized pilot study in a tertiary care hospital. PARTICIPANTS: Thirty patients of microbiologically proven fungal keratitis divided randomly in two groups of 15 patients each... CONCLUSION: Topical 1% voriconazole was found to be safe and effective drug in primary management of fungal keratitis, its efficacy matching conventional natamycin. There was no added advantage of using topical 1% voriconazole over topical natamycin as primary treatment in fungal keratitis. (c) 2011 The Authors. Clinical and Experimental Ophthalmology (c) 2011 Royal Australian and New Zealand College of Ophthalmologists.
Comparison of natamycin and voriconazole for the treatment of fungal keratitis. [2010.06]
OBJECTIVE: To conduct a therapeutic exploratory clinical trial comparing clinical outcomes of treatment with topical natamycin vs topical voriconazole for fungal keratitis... CONCLUSIONS: Overall, there were no significant differences in visual acuity, scar size, and perforations between voriconazole- and natamycin-treated patients. There was a trend toward scraping being associated with worse outcomes. Application to Clinical Practice The benefit seen with voriconazole in the subgroup of patients with baseline visual acuity of 20/40 to 20/400 needs to be validated in a confirmatory clinical trial. Trial Registration clinicaltrials.gov Identifier: NCT00557362.
Comparison of natamycin and voriconazole for the treatment of fungal keratitis. 
keratitis... CONCLUSIONS: Overall, there were no significant differences in visual acuity,
Bioanalytical method development and validation of natamycin in rabbit tears and its application to ocular pharmacokinetic studies. [2011.04.05]
A new selective and sensitive high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed for the quantification of natamycin in rabbit tears using amphotericin B as internal standard (IS). Chromatographic separation was achieved on a Luna Cyano column (100 mm x 2 mm, 3 mum) using ammonium acetate buffer (pH 4; 3.5mM): methanol (10:90, v/v) as the mobile phase...
Voriconazole versus natamycin as primary treatment in fungal corneal ulcers. 
divided randomly in two groups of 15 patients each... CONCLUSION: Topical 1% voriconazole was found to be safe and effective drug in
Clinical Trials Related to Natacyn (Natamycin Ophthalmic)
Pilot Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer [Active, not recruiting]
We are planning to evaluate whether voriconazole is a superior treatment to natamycin for
filamentous fungal keratitis in a randomized, masked, controlled trial. The study being
proposed in this application is a pilot study to investigate the safety and feasibility of
conducting a larger study and to generate preliminary data.
Mycotic Ulcer Treatment Trial I [Recruiting]
A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine [Recruiting]
The purpose of this study is to determine the effectiveness of 1. 25% povidone-iodine
ophthalmic solution for the treatment of small to medium sized fungal corneal ulcers
compared with an antifungal antibiotic.