NATACYN SUMMARY
Natacyn®
(natamycin ophthalmic suspension)
5%
Sterile
NATACYN® (natamycin ophthalmic suspension) 5% is a sterile, antifungal drug for topical ophthalmic administration.
NATACYN (natamycin ophthalmic suspension) 5% is indicated for the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis. As in other forms of suppurative keratitis, initial and sustained therapy of fungal keratitis should be determined by the clinical diagnosis, laboratory diagnosis by smear and culture of corneal scrapings and drug response. Whenever possible the in vitro activity of natamycin against the responsible fungus should be determined. The effectiveness of natamycin as a single agent in fungal endophthalmitis has not been established.
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NEWS HIGHLIGHTS
Published Studies Related to Natacyn (Natamycin Ophthalmic)
Successful salvage treatment of Scedosporium apiospermum keratitis with topical voriconazole after failure of natamycin. [2009.06]
CONCLUSIONS: The voriconazole 1% eye drop used alone is a promising, cost-effective, safe option for managing fungal keratitis, even that caused by S. apiospermum. It may have a larger role to play than simply that of adjunctive therapy.
Effect of topical 0.5% povidone-iodine compared to 5% natamycin in fungal keratitis caused by Fusarium solani in a rabbit model: a pilot study. [2008.11]
PURPOSE: To evaluate the efficacy of topical administration of 0.5% povidone-iodine in experimental Fusarium solani keratitis in rabbits... CONCLUSIONS: Our study demonstrates important methodological considerations in the use of in vivo animal models for the testing of antifungal agents. Using this sample size and methodology of counting CFU, topical 0.5% povidone-iodine demonstrated no benefit in the treatment of experimental Fusarium solani when compared with topical 5% natamycin.
Effect of topical 0.5% povidone-iodine compared to 5% natamycin in fungal keratitis caused by Fusarium solani in a rabbit model: a pilot study. [2008.11]
PURPOSE: To evaluate the efficacy of topical administration of 0.5% povidone-iodine in experimental Fusarium solani keratitis in rabbits... CONCLUSIONS: Our study demonstrates important methodological considerations in the use of in vivo animal models for the testing of antifungal agents. Using this sample size and methodology of counting CFU, topical 0.5% povidone-iodine demonstrated no benefit in the treatment of experimental Fusarium solani when compared with topical 5% natamycin.
Preparation and characterisation of natamycin: gamma-cyclodextrin inclusion complex and its evaluation in vaginal mucoadhesive formulations. [2008.10]
Novel formulations of vaginal bioadhesive tablets were prepared where the natamycin was complexed with gamma-cyclodextrin (NT-gamma CyD) to increase the solubility and stability of NT in aqueous solutions and reduce the side effects of the drug without decreasing antimycotic activity...
Natamycin treatment of experimental Candida albicans induced keratomycosis in rabbits. [2007.12]
CONCLUSION: It is concluded that natamycin has a significant effect (p < 0.01) against Candida albicans in treating experimental keratomycosis.
Clinical Trials Related to Natacyn (Natamycin Ophthalmic)
Pilot Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer [Active, not recruiting]
We are planning to evaluate whether voriconazole is a superior treatment to natamycin for
filamentous fungal keratitis in a randomized, masked, controlled trial. The study being
proposed in this application is a pilot study to investigate the safety and feasibility of
conducting a larger study and to generate preliminary data.
Mycotic Ulcer Treatment Trial I [Not yet recruiting]
A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine [Not yet recruiting]
The purpose of this study is to determine the effectiveness of 1. 25% povidone-iodine
ophthalmic solution for the treatment of small to medium sized fungal corneal ulcers
compared with an antifungal antibiotic.
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