DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Naropin (Ropivacaine Hydrochloride Monohydrate) - Summary



Naropin® Injection contains ropivacaine HCl which is a member of the amino amide class of local anesthetics.   Naropin Injection is a sterile, isotonic solution that contains the enantiomerically pure drug substance, sodium chloride for isotonicity and water for injection. Sodium hydroxide and/or hydrochloric acid may be used for pH adjustment.   It is administered parenterally.

Naropin is indicated for the production of local or regional anesthesia for surgery and for acute pain management.

Surgical Anesthesia: epidural block for surgery including cesarean section; major nerve block; local infiltration
Acute Pain Management: epidural continuous infusion or intermittent bolus, eg, postoperative or labor; local infiltration

See all Naropin indications & dosage >>


Published Studies Related to Naropin (Ropivacaine)

Analgesic efficacy of caudal dexamethasone combined with ropivacaine in children undergoing orchiopexy. [2014]
undergoing day-case orchiopexy... CONCLUSIONS: The addition of dexamethasone 0.1 mg kg(-1) to ropivacaine for

Does the addition of tramadol and ketamine to ropivacaine prolong the axillary brachial plexus block? [2014]
ropivacaine in brachial plexus anesthesia... CONCLUSION: We conclude that when added to brachial plexus analgesia at a dose of

Effectiveness of multimodal pain management after bipolar hemiarthroplasty for hip fracture: a randomized, controlled study. [2013]
injections in patients undergoing bipolar hip hemiarthroplasty... CONCLUSIONS: Multimodal pain management provides additional pain relief until the

A prospective, randomized, blinded study of continuous ropivacaine infusion in the median sternotomy incision following cardiac surgery. [2013]
ropivacaine infusion of into the sternal wound... CONCLUSIONS: The phase III trial did not show improvement in time to extubation

Catheter-based donor site analgesia after rib grafting: a prospective, randomized, double-blinded clinical trial comparing ropivacaine and bupivacaine. [2013]
analgesia after rib harvest... CONCLUSIONS: The use of catheter-based analgesia after rib harvesting provides

more studies >>

Clinical Trials Related to Naropin (Ropivacaine)

Intraperitoneal Ropivacaine Nebulization for Pain Control After Laparoscopic Surgery [Completed]

Ropivacaine With Clonidine For Pediatric Rectus Sheath Blocks- The Magic Combination [Not yet recruiting]
Background: Millions of pediatric patients undergo laparoscopic surgeries every year and many of them suffer significant pain and anxiety. Patient's anxiety correlates with the severity of pain and effective postoperative analgesia is necessary for optimal recovery. Single injections ultrasound guided rectus sheath blocks provide satisfactory postoperative analgesia after pediatric laparoscopic appendectomy, however they are short lived. Searching for a blocking agent that last long enough to outlast pain and has minimal side effects is a difficult task. Using a combination of drugs yielded mixed results. Few pediatric studies showed at best a weak trend in favor of clonidine prolonging analgesia after some blocks, but anxiolytic properties of clonidine were not investigated. This study will compare rectus sheath ropivacaine blocks with ropivacaine and clonidine blocks. Methods: One hundred pediatric patients (10-17 years old) scheduled for laparoscopic appendectomy will be double blinded and randomized to the two treatment groups: the Ropivacaine Group will receive ropivacaine 0. 5% (10 ml) injected bilaterally in the posterior rectus sheath, at the umbilicus location, and Ropivacaine Clonidine Group will receive ropivacaine 0. 5% (10 ml) and clonidine (2mcg/kg). Post-operative analgesia will be provided with ketorolac and acetaminophen around the clock, and morphine, or/and oxycodone as needed. The primary aim is to determine if ropivacaine combined with clonidine prolongs duration of paresthesia. The secondary aims are to determine if the use of clonidine decreases anxiety level, prolongs duration of analgesia, and decreases pain severity at umbilicus laparoscopic site, reduces the need for analgesics, improves satisfaction with pain control, and is associated with complications such as oversedation, hypotension, and bradycardia. Conclusions: Every hour of excellent analgesia count and a prolongation of block duration by at least 50% is clinical relevant. The investigators hypothesize that rectus sheath injections with ropivacaine and clonidine offer improved pain management compared to ropivacaine alone.

Intraperitoneal Ropivacaine Nebulization for Pain Control After Gynecologic Laparoscopic Surgery [Completed]

Ropivacaine Hypobaric Spinal Anaesthesia in Traumatic Hip Surgery [Completed]

Surgical Pain Control With Ropivacaine by Atomized Delivery [Recruiting]
The purpose of this research is to find out the good and bad effects of spraying a local anesthetic called Ropivacaine (numbing medicine)into the abdominal cavity prior to surgery. Ropivacaine is a local anesthetic used to block pain in the body. There are studies showing that Ropivacaine decreases the pain of surgery with minimally invasive (laparoscopic) appendix and gallbladder removal but has not been tried in robotic pelvic surgery.

more trials >>

Reports of Suspected Naropin (Ropivacaine) Side Effects

Anaphylactic Shock (14)Cardiac Arrest (6)Overdose (5)Thrombocytopenia (5)Neutropenia (5)Headache (4)Salivary Hypersecretion (4)Hypersomnia (4)Hypotension (4)Memory Impairment (4)more >>

Page last updated: 2015-08-10

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2015