Naropin® Injection contains ropivacaine HCl which is a member of the amino amide class of local anesthetics. Naropin Injection is a sterile, isotonic solution that contains the enantiomerically pure drug substance, sodium chloride for isotonicity and Water for Injection. Sodium hydroxide and/or hydrochloric acid may be used for pH adjustment. It is administered parenterally.
Naropin is indicated for the production of local or regional anesthesia for surgery and for acute pain management.
Surgical Anesthesia:epidural block for surgery including cesarean section; major nerve block; local infiltration
Acute Pain Management:epidural continuous infusion or intermittent bolus, eg, postoperative or labor; local infiltration
Published Studies Related to Naropin (Ropivacaine)
A randomised controlled trial for the effectiveness of intra-articular
Ropivacaine and Bupivacaine on pain after knee arthroscopy: the DUPRA (DUtch Pain
Relief after Arthroscopy)-trial. 
anaesthesia... CONCLUSIONS: The results of this randomised clinical trial demonstrate improved
The effect of intraperitoneal ropivacaine on pain after laparoscopic colectomy: a prospective randomized controlled trial. [2011.11]
BACKGROUND: Although laparoscopic procedures are becoming more common, postoperative pain remains a major factor causing delayed patient recovery. There have been several trials to reduce pain by instilling local anesthetics into the peritoneal cavity, but there has been no study on prolonged ( approximately 300 min) or intensive surgery. We investigated the analgesic effect of intraperitoneal ropivacaine instillation after laparoscopic colectomy... CONCLUSIONS: The intraperitoneal instillation of ropivacaine was effective in reducing postoperative pain and in shortening the recovery course after laparoscopic colectomy. The additional instillation of ropivacaine at the end of the surgery proved even more effective. Crown Copyright (c) 2011. Published by Elsevier Inc. All rights reserved.
Ropivacaine Continuous Wound Infusion Versus Epidural Morphine for Postoperative Analgesia After Cesarean Delivery: A Randomized Controlled Trial. [2011.10.24]
Background:The infusion of local anesthetic in the surgical wound is helpful in the multimodal management of postoperative pain. We hypothesized that local anesthetic wound infusion after cesarean delivery would provide better pain control than epidural morphine analgesia.Methods:Healthy, term women scheduled for elective cesarean delivery were included in this assessor-blinded, randomized study...
Epidural anesthesia and postoperative analgesia with ropivacaine and fentanyl in off-pump coronary artery bypass grafting: a randomized, controlled study. [2011.09.18]
ABSTRACT: BACKGROUND: Our aim was to assess the efficacy of thoracic epidural anesthesia (EA) followed by postoperative epidural infusion (EI) and patient-controlled epidural analgesia (PCEA) with ropivacaine/fentanyl in off-pump coronary artery bypass grafting (OPCAB)... CONCLUSIONS: In OPCAB, EA with ropivacaine/fentanyl decreases arterial pressure transiently, optimizes myocardial performance and influences the perioperative fluid and vasoactive therapy. Postoperative EI combined with PCEA improves lung function and reduces time to extubation. TRIAL REGISTRATION: NCT01384175.
Effect of dexamethasone on the duration of interscalene nerve blocks with ropivacaine or bupivacaine. [2011.09]
BACKGROUND: Pain after shoulder surgery is often treated with interscalene nerve blocks. Single-injection blocks are effective, but time-limited. Adjuncts such as dexamethasone may help. We thus tested the hypothesis that adding dexamethasone significantly prolongs the duration of ropivacaine and bupivacaine analgesia and that the magnitude of the effect differs among the two local anaesthetics... CONCLUSIONS: Dexamethasone prolongs analgesia from interscalene blocks using ropivacaine or bupivacaine, with the effect being stronger with ropivacaine. However, block duration was longer with plain bupivacaine than ropivacaine. Thus, although dexamethasone prolonged the action of ropivacaine more than that of bupivacaine, the combined effect of dexamethasone and either drug produced nearly the same 22 h of analgesia.
Clinical Trials Related to Naropin (Ropivacaine)
Intraperitoneal Ropivacaine Nebulization for Pain Control After Laparoscopic Surgery [Recruiting]
Ropivacaine Hypobaric Spinal Anaesthesia in Traumatic Hip Surgery [Recruiting]
Intraperitoneal Ropivacaine Nebulization for Pain Control After Gynecologic Laparoscopic Surgery [Recruiting]
Surgical Pain Control With Ropivacaine by Atomized Delivery [Recruiting]
The purpose of this research is to find out the good and bad effects of spraying a local
anesthetic called Ropivacaine (numbing medicine)into the abdominal cavity prior to surgery.
Ropivacaine is a local anesthetic used to block pain in the body. There are studies showing
that Ropivacaine decreases the pain of surgery with minimally invasive (laparoscopic)
appendix and gallbladder removal but has not been tried in robotic pelvic surgery.
Labor Analgesia With Ropivacaine and Clonidine [Completed]
The aim of the present study was to examine, for pain relief during labor, the efficacy of
two pharmacological approaches — the 0. 125% ropivacaine alone and the 0. 0625% ropivacaine
added to 75 ug clonidine, both by epidural administration. The effect of the drugs on mother
and newborn was also determined.
Reports of Suspected Naropin (Ropivacaine) Side Effects
Anaphylactic Shock (14),
Cardiac Arrest (6),
Salivary Hypersecretion (4),
Memory Impairment (4), more >>