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Narcan (Naloxone Hydrochloride) - Summary

 


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NARCAN SUMMARY

NARCAN®
(Naloxone Hydrochloride Injection, USP)
Opioid Antagonist
Rx only

NARCAN (naloxone hydrochloride injection, USP), an opioid antagonist, is a synthetic congener of oxymorphone. In structure it differs from oxymorphone in that the methyl group on the nitrogen atom is replaced by an allyl group.

NARCAN is indicated for the complete or partial reversal of opioid depression, including respiratory depression, induced by natural and synthetic opioids, including propoxyphene, methadone and certain mixed agonist-antagonist analgesics: nalbuphine, pentazocine, butorphanol, and cyclazocine. NARCAN is also indicated for diagnosis of suspected or known acute opioid overdosage.

NARCAN may be useful as an adjunctive agent to increase blood pressure in the management of septic shock (see CLINICAL PHARMACOLOGY; Adjunctive Use in Septic Shock).


See all Narcan indications & dosage >>

NARCAN NEWS HIGHLIGHTS

Published Studies Related to Narcan (Naloxone)

Acylated ghrelin inhibits spontaneous luteinizing hormone pulsatility and responsiveness to naloxone but not that to gonadotropin-releasing hormone in young men: evidence for a central inhibitory action of ghrelin on the gonadal axis. [2008.09]

Buprenorphine/naloxone treatment in primary care is associated with decreased human immunodeficiency virus risk behaviors. [2008.07]

Effect of low-dose naloxone infusion on fentanyl requirements in critically ill children. [2008.05]

A study of naloxone effect on urinary retention in the patient receiving morphine patient-controlled analgesia. [2008.03]

Long-term treatment with buprenorphine/naloxone in primary care: results at 2-5 years. [2008.03]

more >>

Clinical Trials Related to Narcan (Naloxone)

Safety and Tolerability of Buprenorphine/Naloxone Film Strips [Active, not recruiting]

Preference for Subutex® (Buprenorphine) Versus Suboxone® (Buprenorphin/Naloxone) in Opioid Dependent Patients on Subutex (Study P05094)(COMPLETED) [Completed]

Abuse Potential of Buprenorphine/Naloxone [Terminated]

Pharmacokinetic Interactions Between Buprenorphine and Tipranavir/Ritonavir [Completed]

Optimal Dose of Prophylactic Naloxone in Reducing Opioid-Induced Side Effects in Children/Adolescents [Recruiting]

more >>

Page last updated: 2008-11-03

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