DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Naproxen (Naproxen) - Summary

 


Nutrilib.com
A comprihensive source of nutritional information

BOX WARNING

Cardiovascular Risk

  • NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease maybe at greater risk (see WARNINGS).
  • Naproxen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).

Gastrointestinal Risk

  • NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (see WARNINGS).
 

NAPROXEN SUMMARY

NAPROXEN DELAYED-RELEASE TABLETS

Naproxen is a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs. The chemical name for naproxen is (+)-6-Methoxy-a-methyl-2-naphthaleneacetic acid. Naproxen has the following structural formula.

Carefully consider the potential benefits and risks of naproxen delayed-release tablets and other treatment options before deciding to use naproxen delayed-release tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).

Naproxen delayed-release tablets are indicated:

  • For the relief of the signs and symptoms of rheumatoid arthritis
  • For the relief of the signs and symptoms of osteoarthritis
  • For the relief of the signs and symptoms of ankylosing spondylitis
  • For the relief of the signs and symptoms of juvenile arthritis

Naproxen delayed-release tablets are not recommended for initial treatment of acute pain because the absorption of naproxen is delayed compared to absorption from other naproxen-containing products (see CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION).


See all Naproxen indications & dosage >>

NAPROXEN NEWS HIGHLIGHTS

Media Articles Related to Naproxen

NicOx' Naproxcinod Shows Highly Significant Reduction In Daytime Blood Pressure Versus Naproxen
Source: Hypertension News From Medical News Today [2008.11.13]

Celebrex, Naproxen Won't Prevent Mental Decline
Source: MedicineNet celecoxib Specialty [2008.05.13]

more >>

Published Studies Related to Naproxen

Comparison of naproxen with placebo for the management of noncyclical breast pain: a randomized, double-blind, controlled trial. [2008.11]

A comparison of the blood pressure changes of lumiracoxib with those of ibuprofen and naproxen. [2008.08]

Multimechanistic (sumatriptan-naproxen) early intervention for the acute treatment of migraine. [2008.07.08]

Naproxen suppository for perineal pain after vaginal delivery. [2008.07]

Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a Randomized, Controlled Trial of Naproxen and Celecoxib. [2008.05.12]

more >>

Clinical Trials Related to Naproxen

Study Evaluating the Bioavailability of Naproxen 500 mg in Three Formulations [Completed]

Oral vs Rectal Admin of Naproxen for Post-Vag Perineal Pain Control [Completed]

Multicenter, Double-Blind, Randomized, Placebo Controlled, Comparison of the Efficacy and Safety of Valdecoxib 10 mg Once Daily and Naproxen 500 mg Twice Daily in Treating the Signs and Symptoms of Rheumatoid Arthritis (RA) in a Severe Rheumatoid Arthritis Population [Completed]

A Phase II Trial of Calcitriol and Naproxen in Patients With Recurrent Prostate Cancer [Suspended]

Study Evaluating the Gastrointestinal Safety of PLA-695 Compared to Placebo and Naproxen [Completed]

more >>

NAPROXEN PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 6 ratings/reviews, Naproxen has an overall score of 5.83. The effectiveness score is 7.33 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Naproxen review by 36 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   auto accident, severe whiplash
Dosage & duration:   1 tablet 3 times a day taken 1 tablet 3 times a day for the period of 10 days
Other conditions:   pinched nerve, headaches
Other drugs taken:   cyclobenzaprine
  
Reported Results
Benefits:   helped aleviate whip lash symptoms
Side effects:   none that i noticed
Comments:   i took the medications for the prescribed time and symptoms improved, however, I still have some symptoms which are being treated through physical therapy since the accident was only in December

 

Naproxen review by 16 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Juvenile Idiopathic Arthritis
Dosage & duration:   500mg taken twice a day/at 12 hour intervals for the period of Four weeks
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   The treatment did not affect the level of joint pain that I experienced, nor did it improve joint stiffness. I cannot comment on it's effect on inflammation as my inflammation tends not to be visible anyway. This may be the reason that Naproxen did not benefit me
Side effects:   Caused nausea and stomach pain. The nausea would alleviate a couple of hours before the next dose was due, and start within an hour of the dose. It did not cause actual vomitting, but there were a few occasions on which I felt so nauseous I was convinced I would be sick at any moment.
Comments:   I would never take Naproxen again without having a LONG discussion with both a doctor and pharmacist.

 

Naproxen review by 52 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   arthritis
Dosage & duration:   3 x 10mg / day taken daily for the period of 2 years
Other conditions:   nil
Other drugs taken:   paracetamol
  
Reported Results
Benefits:   reduced the pain and swelling
Side effects:   caused severe abdominal cramps and bouts of diarrhoea and constipation
Comments:   given over a period of 3 years... at first daily and then, due to stomache irritation, reduced to use only when needed. Stomache problems evident when taking 3 a day for 2 or more days. Given tab for coating the stomache.

See all Naproxen reviews / ratings >>

Page last updated: 2008-11-13

-- advertisement -- The American Red Cross

We comply with
HONcode standard.
Verify here.
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2008